MALT lymphoma pathophysiology: Difference between revisions
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=== Associations === | === Associations === | ||
Gastric MALT lymphoma is frequently associated (72-98%) with chronic [[inflammation]] as a result of the presence of ''[[Helicobacter pylori]]''. <ref>{{cite journal | author = Parsonnet J, Hansen S, Rodriguez L, Gelb A, Warnke R, Jellum E, Orentreich N, Vogelman J, Friedman G | title = Helicobacter pylori infection and gastric lymphoma. | journal = N Engl J Med | volume = 330 | issue = 18 | pages = 1267-71 | year = 1994 | id = PMID 8145781}}</ref> | Gastric MALT lymphoma is frequently associated (72-98%) with chronic [[inflammation]] as a result of the presence of ''[[Helicobacter pylori]]''. <ref>{{cite journal | author = Parsonnet J, Hansen S, Rodriguez L, Gelb A, Warnke R, Jellum E, Orentreich N, Vogelman J, Friedman G | title = Helicobacter pylori infection and gastric lymphoma. | journal = N Engl J Med | volume = 330 | issue = 18 | pages = 1267-71 | year = 1994 | id = PMID 8145781}}</ref> | ||
In other sites, chronic immune stimulation is also suspected in the pathogenesis (e.g. association between chronic [[autoimmune diseases]] such as [[Sjögren's syndrome]] and [[Hashimoto's thyroiditis]], and MALT lymphoma of the [[salivary gland]] and the [[thyroid]]). | In other sites, chronic immune stimulation is also suspected in the pathogenesis (e.g. association between chronic [[autoimmune diseases]] such as [[Sjögren's syndrome]] and [[Hashimoto's thyroiditis]], and MALT lymphoma of the [[salivary gland]] and the [[thyroid]]). | ||
Revision as of 18:15, 24 August 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
Genetics
A t(11;18)(q21;q21) chromosomal translocation, giving rise to a AP12-MLT fusion gene, is predictive of poor response to eradication therapy. [1]
Two other genetic alterations, t(1;14)(p22;q32) and t(14;18)(q32;q21), which deregulate BCL10 and MALT1-genes respectively, and seem to turn-on the same pathway as API2-MLT (i.e., that of NF-kB).
Associations
Gastric MALT lymphoma is frequently associated (72-98%) with chronic inflammation as a result of the presence of Helicobacter pylori. [2]
In other sites, chronic immune stimulation is also suspected in the pathogenesis (e.g. association between chronic autoimmune diseases such as Sjögren's syndrome and Hashimoto's thyroiditis, and MALT lymphoma of the salivary gland and the thyroid).
References
- ↑ Liu H, Ruskon-Fourmestraux A, Lavergne-Slove A, Ye H, Molina T, Bouhnik Y, Hamoudi R, Diss T, Dogan A, Megraud F, Rambaud J, Du M, Isaacson P (2001). "Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy". Lancet. 357 (9249): 39–40. PMID 11197361.
- ↑ Parsonnet J, Hansen S, Rodriguez L, Gelb A, Warnke R, Jellum E, Orentreich N, Vogelman J, Friedman G (1994). "Helicobacter pylori infection and gastric lymphoma". N Engl J Med. 330 (18): 1267–71. PMID 8145781.