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==Overview==
==Overview==
'''M2''' is a subtype of [[Acute myeloid leukemia|AML]] (Acute Myeloid Leukemia).
'''M2''' is a subtype of [[Acute myeloid leukemia|AML]] (Acute Myeloid Leukemia).
This subtypeis characterized by a [[translocation]] of a part of chromosome 8 to chromosome 21, written as t(8;21). On both sides of the chromosome, now containing pieces from two chromosomes, the DNA codes for different proteins. These two proteins are now being created as one single large protein, with a different effect in the body as the two proteins originally coded by the two different chromosomes.
==Pathophysiology==
This subtype is characterized by a [[translocation]] of a part of chromosome 8 to chromosome 21, written as t(8;21). On both sides of the chromosome, now containing pieces from two chromosomes, the DNA codes for different proteins. These two proteins are now being created as one single large protein, with a different effect in the body as the two proteins originally coded by the two different chromosomes.
The two different proteins that are fused together are:
The two different proteins that are fused together are:
*[[RUNX1]]
*[[RUNX1]]
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{{Hematological malignancy histology}}
{{Hematological malignancy histology}}


[[Category:Hematology]]
[[Category:Hematology]]
[[Category:Oncology]]
[[Category:Types of cancer]]
[[Category:Types of cancer]]
[[Category:Disease]]
[[Category:Disease]]

Latest revision as of 19:11, 24 August 2015

M2 AML
ICD-O: 9874/3

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

M2 is a subtype of AML (Acute Myeloid Leukemia).

Pathophysiology

This subtype is characterized by a translocation of a part of chromosome 8 to chromosome 21, written as t(8;21). On both sides of the chromosome, now containing pieces from two chromosomes, the DNA codes for different proteins. These two proteins are now being created as one single large protein, with a different effect in the body as the two proteins originally coded by the two different chromosomes. The two different proteins that are fused together are:

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References


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