Lymphangitis natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vishal Devarkonda, M.B.B.S[2]

Overview

Depending on etiologies, lymphangitis has spectrum of natural history, complication, and prognosis. Specific natural history, complications and prognosis for individual infections are discussed in detail separately.

Natural History

Acute Lymphangitis

  • Course of the disease varies from organism to organism.
  • Generally, if the organism is not locally contained by body defenses, it could lead to bacteremia, sepsis, septic shock, multi-organ failure, and death.

Lymphangitis carcinomatosa

  • An extremely aggressive form metastasized malignant tumor
  • In 1996, Bruce DM and colleagues reported, 50% mortality within 3 months of onset of first respiratory symptoms

Complications

Acute Lymphangitis

  • Cellulitis
  • Pneumonia
  • Endocarditis
  • Osteomyelitis
  • Meningitis
  • Septic artheritis
  • Peritonitis
  • Visceral abscess
  • Septic shock
  • Multi-organ failure

Lymphangitis carcinomatosa

  • Respiratory failure
  • Right Heart failure

Prognosis

Acute Lymphangitis

  • With appropriate antimicrobial treatment, most attacks of acute lymphangitis resolve within days to weeks.

Lymphangitis carcinomatosa

  • Being a manifestation of metastatic primary tumor. Lymphangitis carcinomatosa has extremely poor prognosis.

References

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