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{{Lung cancer}}
{{Lung cancer}}


{{CMG}}; '''Associate Editor(s)-In-Chief:''' Kim-Son H. Nguyen, M.D., M.P.A., Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA, {{CZ}}
{{CMG}}; {{AE}}  {{KSH}} {{CZ}} {{SH}}


==Overview==
==Overview==
The direct cause of lung cancers is DNA mutations that often result in activation of proto-oncogenes (e.g. '''K-RAS''')or the inactivation of tumors suppressor genes (e.g. '''TP53'''). The risk of these genetic mutations may be increased following exposure to environmental components, which are regarded as risk factors that predispose to the development of lung cancer.
The direct cause of lung cancer is [[DNA mutations]] that often result in either activation of [[Proto-oncogene|proto-oncogenes]] (e.g. '''[[KRAS|K-RAS]]''') or the inactivation of [[Tumor suppressor gene|tumors suppressor genes]] (e.g. '''[[TP53]]''') or both. The risk of these [[genetic mutations]] may be increased following exposure to environmental insults.
 
==Causes==
==Causes==
*The direct cause of lung cancers is DNA mutations that often result in activation of proto-oncogenes (e.g. '''K-RAS''') or the inactivation of tumors suppressor genes (e.g. '''TP53''').
*The direct cause of lung cancer is [[DNA mutations]] that often result in either activation of [[Proto-oncogene|proto-oncogenes]] (e.g. '''[[KRAS|K-RAS]]''') or the inactivation of [[Tumor suppressor gene|tumors suppressor genes]] (e.g. '''[[TP53]]''') or both.<ref>American Cancer Society. Cancer Facts & Figures 2017.
*The risk of these genetic mutations may be increased following exposure to environmental components, which are regarded as risk factors that predispose to the development of lung cancer.
Atlanta: American Cancer Society; 2017.</ref><ref name="pmid23122493">{{cite journal |vauthors=Karachaliou N, Mayo C, Costa C, Magrí I, Gimenez-Capitan A, Molina-Vila MA, Rosell R |title=KRAS mutations in lung cancer |journal=Clin Lung Cancer |volume=14 |issue=3 |pages=205–14 |year=2013 |pmid=23122493 |doi=10.1016/j.cllc.2012.09.007 |url=}}</ref>
*To view a comprehensive list of risk factors that increase the risk of lung cancer, click [[Lung cancer#Risk factors|'''here''']]
*The risk of these [[genetic mutations]] may be increased following exposure to environmental insults, which are regarded as [[Risk factor|risk factors]] that [[Predisposition|predispose]] to the development of lung cancer.
 
*To view a comprehensive list of [[Risk factor|risk factors]] that increase the risk of lung cancer, click [[Lung cancer risk factors|'''here''']].


==References==
==References==
{{reflist|2}}
{{reflist|2}}
[[Category:Disease]]
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[[Category:Pulmonology]]
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Latest revision as of 13:47, 3 July 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kim-Son H. Nguyen M.D. Cafer Zorkun, M.D., Ph.D. [2] Dildar Hussain, MBBS [3]

Overview

The direct cause of lung cancer is DNA mutations that often result in either activation of proto-oncogenes (e.g. K-RAS) or the inactivation of tumors suppressor genes (e.g. TP53) or both. The risk of these genetic mutations may be increased following exposure to environmental insults.

Causes

  • To view a comprehensive list of risk factors that increase the risk of lung cancer, click here.

References

  1. American Cancer Society. Cancer Facts & Figures 2017. Atlanta: American Cancer Society; 2017.
  2. Karachaliou N, Mayo C, Costa C, Magrí I, Gimenez-Capitan A, Molina-Vila MA, Rosell R (2013). "KRAS mutations in lung cancer". Clin Lung Cancer. 14 (3): 205–14. doi:10.1016/j.cllc.2012.09.007. PMID 23122493.

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