Lithium carbonate: Difference between revisions

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{{DrugProjectFormSinglePage
 
|authorTag={{PB}}
|genericName=Lithium carbonate
|aOrAn=a
|drugClass=mood Stabilizer
|indication=bipolar disorder, maintenance therapy and manic episode
|adverseReactions=acne, hypothyroidism, weight increased, gastritis, nausea, xerostomia, leukocytosis, fine tremor, hyperreflexia, deep tendon, nephrotoxicity, polyuria, increased thirst.
|blackBoxWarningTitle=<b><span style="color:#FF0000;">TITLE</span></b>
|blackBoxWarningBody=<i><span style="color:#FF0000;">Condition Name:</span></i> (Content)
|fdaLIADAdult=*Bipolar disorder, maintenance therapy
:* Maintenance 900 to 1200 mg/day PO in 2 to 3 divided doses
*Bipolar disorder, manic episode
:*1800 mg/day PO in 2 to 3 divided doses
|offLabelAdultGuideSupport=There is limited information about <i>Off-Label Guideline-Supported Use</i> of Lithium carbonate in adult patients.
|offLabelAdultNoGuideSupport=There is limited information about <i>Off-Label Non–Guideline-Supported Use</i> of Lithium carbonate in adult patients.
|fdaLIADPed=*Safety below the age of 12 have not been established.
B*ipolar disorder, maintenance therapy
:* 12 yr and older, extended-release tablets, maintenance, 900 to 1200 mg/day ORALLY in 2 to 3 divided doses; desired serum lithium levels ranging between 0.6 to 1.2 mEq/L
*Bipolar disorder, maintenance therapy
:* Immediate-release tablet and capsule formulations, maintenance, 300 mg PO 3 to 4 times daily
Bipolar disorder, manic episode
:* 12 yr and older, extended-release tablets, acute mania, 1800 mg/day PO in 2 to 3 divided doses
|offLabelPedGuideSupport=There is limited information about <i>Off-Label Guideline-Supported Use</i> of Lithium carbonate in pediatric patients.
|offLabelPedNoGuideSupport=There is limited information about <i>Off-Label Non–Guideline-Supported Use</i> of Lithium carbonate in pediatric patients.
|drugBox={{chembox2
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 476992822
| Name = Lithium carbonate
| ImageFile = 225px-Lithium carbonate.jpg
| ImageSize = 225px
| ImageName = Lithium carbonate
| IUPACName = Lithium carbonate
| OtherNames = Dilithium carbonate, Carbolith, Cibalith-S, Duralith, Eskalith, Lithane, Lithizine, Lithobid, Lithonate, Lithotabs Priadel, [[Zabuyelite]]
| Section1 = {{Chembox Identifiers
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 10654
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 2BMD2GNA4V
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 1200826
| InChI = 1/CH2O3.2Li/c2-1(3)4;;/h(H2,2,3,4);;/q;2*+1/p-2
| InChIKey = XGZVUEUWXADBQD-NUQVWONBAY
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 6504
| SMILES = [Li+].[Li+].[O-]C([O-])=O
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/CH2O3.2Li/c2-1(3)4;;/h(H2,2,3,4);;/q;2*+1/p-2
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = XGZVUEUWXADBQD-UHFFFAOYSA-L
| CASNo = 554-13-2
| CASNo_Ref = {{cascite|correct|CAS}}
| PubChem = 11125
| RTECS = OJ5800000
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00801
}}
| Section2 = {{Chembox Properties
| Li=2|C=1|O=3
| Appearance = Odorless white powder
| Density = 2.11 g/cm<sup>3</sup>
| MeltingPtC = 720-723
| BoilingPtC = 1310
| Boiling_notes = decomposes
| Solubility = 1.54 g/100ml (0 °C)<br> 1.32 g/100ml (20 °C)<br> 1.27 g/100ml (25 °C)<br> 1.00 g/100ml (60 °C)<br> 0.72 g/100ml (100 °C)
| SolubleOther = insoluble in [[acetone]], [[ammonia]] and [[ethanol]]
| RefractIndex = 1.428 <ref>Pradyot Patnaik. ''Handbook of Inorganic Chemicals''. McGraw-Hill, 2002, ISBN 0-07-049439-8</ref>
}}
| Section4 = {{Chembox Thermochemistry
|  DeltaGf = -1132.4 kJ/mol<ref name=chemister>http://chemister.ru/Database/properties-en.php?dbid=1&id=608</ref>
|  DeltaHf = -16.46 kJ/g<br> -1215.6 kJ/mol<ref name=chemister />
|  DeltaHc =
|  Entropy = 90.37 J/mol·K<ref name=chemister />
|  HeatCapacity = 1.341 J/(g·K)<br> 97.4 J/mol·K<ref name=chemister />
}}
|alcohol=Alcohol-Lithium carbonate interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
}}

Revision as of 20:13, 26 May 2014