Listeriosis medical therapy: Difference between revisions
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==Principles of Therapy== | ==Principles of Therapy== | ||
* [[Ampicillin]], [[amoxicillin]], and [[penicillin G]] have been considered effective for listeriosis. For patients unable to tolerate [[beta-lactam]]s, [[TMP/SMZ|trimethoprim-sulfamethoxazole]] may be used alternatively. [[Chloramphenicol]] is not regarded as an acceptable option due to high treatment failure and relapse rates.<ref | * [[Ampicillin]], [[amoxicillin]], and [[penicillin G]] have been considered effective for listeriosis. For patients unable to tolerate [[beta-lactam]]s, [[TMP/SMZ|trimethoprim-sulfamethoxazole]] may be used alternatively. [[Chloramphenicol]] is not regarded as an acceptable option due to high treatment failure and relapse rates.<ref>{{Cite journal | issn = 0162-0886 | volume = 4 | issue = 3 | pages = 665–682 | last = Stamm | first = A. M. | coauthors = W. E. Dismukes, B. P. Simmons, C. G. Cobbs, A. Elliott, P. Budrich, J. Harmon | title = Listeriosis in renal transplant recipients: report of an outbreak and review of 102 cases | journal = Reviews of Infectious Diseases | date = 1982-06 | pmid = 6750737 }}</ref> | ||
* Addition of an [[aminoglycoside]], which confers [[synergistic]] [[bactericidal]] effects to [[ampicillin]], is recommended for the treatment of listerial [[bacteremia]], [[endocarditis]], [[brain abscess]], [[meningitis]], or rhombencephalitis.<ref | * Addition of an [[aminoglycoside]], which confers [[synergistic]] [[bactericidal]] effects to [[ampicillin]], is recommended for the treatment of listerial [[bacteremia]], [[endocarditis]], [[brain abscess]], [[meningitis]], or rhombencephalitis.<ref>{{Cite journal | issn = 0098-7484 | volume = 261 | issue = 9 | pages = 1313–1320 | last = Gellin | first = B. G. | coauthors = C. V. Broome | title = Listeriosis | journal = JAMA: the journal of the American Medical Association | date = 1989-03-03 | pmid = 2492614 }}</ref> | ||
* [[Bacteremia]] should be treated for 2 weeks, [[meningitis]] for 3 weeks, [[endocarditis]] for 4 to 6 weeks, and [[brain abscess]] or rhombencephalitis for at least 6 weeks. | * [[Bacteremia]] should be treated for 2 weeks, [[meningitis]] for 3 weeks, [[endocarditis]] for 4 to 6 weeks, and [[brain abscess]] or rhombencephalitis for at least 6 weeks. | ||
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* [[Meningitis]] is the most common clinical manifestation, and antibiotics that penetrate well into the [[cerebrospinal fluid]] should be chosen. | * [[Meningitis]] is the most common clinical manifestation, and antibiotics that penetrate well into the [[cerebrospinal fluid]] should be chosen. | ||
* [[Gastroenteritis]] caused by ''[[Listeria monocytogenes]]'' is usually self-limited and complete recovery typically occurs within 2 days. Persons who have ingested food implicated in outbreaks and who have a high risk of invasive illness may be treated with oral [[ampicillin]] or [[TMP/SMZ|trimethoprim-sulfamethoxazole]] for several days.<ref | * [[Gastroenteritis]] caused by ''[[Listeria monocytogenes]]'' is usually self-limited and complete recovery typically occurs within 2 days. Persons who have ingested food implicated in outbreaks and who have a high risk of invasive illness may be treated with oral [[ampicillin]] or [[TMP/SMZ|trimethoprim-sulfamethoxazole]] for several days.<ref>{{Cite journal | issn = 1058-4838 | volume = 24 | issue = 1 | pages = 1–9; quiz 10-11 | last = Lorber | first = B. | title = Listeriosis | journal = Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America | date = 1997-01 | pmid = 8994747 }}</ref> | ||
==Medical Therapy for ''Listeria monocytogenes'' <SMALL><SMALL><SMALL><SMALL><SMALL>Adapted from ''Clin Infect Dis. 1997;24(1):1-9.'',<ref | ==Medical Therapy for ''Listeria monocytogenes'' <SMALL><SMALL><SMALL><SMALL><SMALL>Adapted from ''Clin Infect Dis. 1997;24(1):1-9.'',<ref>{{Cite journal | issn = 1058-4838 | volume = 24 | issue = 1 | pages = 1–9; quiz 10-11 | last = Lorber | first = B. | title = Listeriosis | journal = Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America | date = 1997-01 | pmid = 8994747 }}</ref> ''Clin Infect Dis. 2005;40(9):1327-32.'',<ref>{{Cite journal | doi = 10.1086/429324 | issn = 1537-6591 | volume = 40 | issue = 9 | pages = 1327–1332 | last = Ooi | first = Say Tat | coauthors = Bennett Lorber | title = Gastroenteritis due to Listeria monocytogenes | journal = Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America | date = 2005-05-01 | pmid = 15825036 }}</ref> and ''Clin Infect Dis. 2004;39(9):1267-84.''<ref>{{Cite journal | doi = 10.1086/425368 | issn = 1537-6591 | volume = 39 | issue = 9 | pages = 1267–1284 | last = Tunkel | first = Allan R. | coauthors = Barry J. Hartman, Sheldon L. Kaplan, Bruce A. Kaufman, Karen L. Roos, W. Michael Scheld, Richard J. Whitley | title = Practice guidelines for the management of bacterial meningitis | journal = Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America | date = 2004-11-01 | pmid = 15494903 }}</ref></SMALL></SMALL></SMALL></SMALL></SMALL>== | ||
<SMALL><font color="#FF4C4C">'''▸ Click on the following categories to expand treatment regimens.'''</font></SMALL> | <SMALL><font color="#FF4C4C">'''▸ Click on the following categories to expand treatment regimens.'''</font></SMALL> |
Revision as of 15:06, 22 July 2014
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Ampicillin, with or without gentamicin, is considered the drug of choice for listeriosis. Patients intolerant of penicillins may be managed with trimethoprim-sulfamethoxazole alternatively. Suggested minimum duration of therapy depends on clinical manifestations: bacteremia for 2 weeks, meningitis for 3 weeks, endocarditis for 4 to 6 weeks, and brain abscess or rhombencephalitis for at least 6 weeks.
Principles of Therapy
- Ampicillin, amoxicillin, and penicillin G have been considered effective for listeriosis. For patients unable to tolerate beta-lactams, trimethoprim-sulfamethoxazole may be used alternatively. Chloramphenicol is not regarded as an acceptable option due to high treatment failure and relapse rates.[1]
- Addition of an aminoglycoside, which confers synergistic bactericidal effects to ampicillin, is recommended for the treatment of listerial bacteremia, endocarditis, brain abscess, meningitis, or rhombencephalitis.[2]
- Bacteremia should be treated for 2 weeks, meningitis for 3 weeks, endocarditis for 4 to 6 weeks, and brain abscess or rhombencephalitis for at least 6 weeks.
- Meningitis is the most common clinical manifestation, and antibiotics that penetrate well into the cerebrospinal fluid should be chosen.
- Gastroenteritis caused by Listeria monocytogenes is usually self-limited and complete recovery typically occurs within 2 days. Persons who have ingested food implicated in outbreaks and who have a high risk of invasive illness may be treated with oral ampicillin or trimethoprim-sulfamethoxazole for several days.[3]
Medical Therapy for Listeria monocytogenes Adapted from Clin Infect Dis. 1997;24(1):1-9.,[4] Clin Infect Dis. 2005;40(9):1327-32.,[5] and Clin Infect Dis. 2004;39(9):1267-84.[6]
▸ Click on the following categories to expand treatment regimens.
L. monocytogenes Infections ▸ Bacteremia ▸ Brain Abscess ▸ Endocarditis ▸ Gastroenteritis ▸ Meningitis ▸ Rhombencephalitis |
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References
- ↑ Stamm, A. M. (1982-06). "Listeriosis in renal transplant recipients: report of an outbreak and review of 102 cases". Reviews of Infectious Diseases. 4 (3): 665–682. ISSN 0162-0886. PMID 6750737. Unknown parameter
|coauthors=
ignored (help); Check date values in:|date=
(help) - ↑ Gellin, B. G. (1989-03-03). "Listeriosis". JAMA: the journal of the American Medical Association. 261 (9): 1313–1320. ISSN 0098-7484. PMID 2492614. Unknown parameter
|coauthors=
ignored (help) - ↑ Lorber, B. (1997-01). "Listeriosis". Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America. 24 (1): 1–9, quiz 10-11. ISSN 1058-4838. PMID 8994747. Check date values in:
|date=
(help) - ↑ Lorber, B. (1997-01). "Listeriosis". Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America. 24 (1): 1–9, quiz 10-11. ISSN 1058-4838. PMID 8994747. Check date values in:
|date=
(help) - ↑ Ooi, Say Tat (2005-05-01). "Gastroenteritis due to Listeria monocytogenes". Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America. 40 (9): 1327–1332. doi:10.1086/429324. ISSN 1537-6591. PMID 15825036. Unknown parameter
|coauthors=
ignored (help) - ↑ Tunkel, Allan R. (2004-11-01). "Practice guidelines for the management of bacterial meningitis". Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America. 39 (9): 1267–1284. doi:10.1086/425368. ISSN 1537-6591. PMID 15494903. Unknown parameter
|coauthors=
ignored (help)