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| ==Antibiotic Therapy for ''Listeria monocytogenes''== | | ==Antibiotic Therapy for ''Listeria monocytogenes''== |
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| * <font color="#FF4C4C">'''Click on the following categories to expand treatment regimens.'''</font>
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| <div style="-webkit-user-select: none;">
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| {|
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| | valign=top |
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| <div style="border-radius: 5px 5px 0 0; border: solid 1px #20538D; border-bottom: 0px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: inset 0 1px 1px rgba(255, 255, 255, 0.5), 0 1px 1px rgba(0, 0, 0, 0.5); height: 30px; line-height: 30px; width: 225px; background: #A1BCDD; text-align: center; margin: 0 18px;">
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| <font color="#FFF">
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| '''''L. monocytogenes''''' '''Infections'''
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| </font>
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| </div>
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| <div class="mw-customtoggle-table01" style="cursor: pointer; border-radius: 0 0 0 0; border: solid 1px #20538D; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: inset 0 1px 1px rgba(255, 255, 255, 0.5), 0 1px 1px rgba(0, 0, 0, 0.5); height: 30px; line-height: 30px; width: 225px; background: #4479BA; margin: 0 18px;">
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| <font color="#FFF">
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| ▸ '''Bacteremia'''
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| </font>
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| </div>
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| <div class="mw-customtoggle-table02" style="cursor: pointer; border-radius: 0 0 0 0; border: solid 1px #20538D; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: inset 0 1px 1px rgba(255, 255, 255, 0.5), 0 1px 1px rgba(0, 0, 0, 0.5); height: 30px; line-height: 30px; width: 225px; background: #4479BA; margin: 0 18px;">
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| <font color="#FFF">
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| ▸ '''Brain Abscess'''
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| </font>
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| </div>
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| <div class="mw-customtoggle-table03" style="cursor: pointer; border-radius: 0 0 0 0; border: solid 1px #20538D; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: inset 0 1px 1px rgba(255, 255, 255, 0.5), 0 1px 1px rgba(0, 0, 0, 0.5); height: 30px; line-height: 30px; width: 225px; background: #4479BA; margin: 0 18px;">
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| <font color="#FFF">
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| ▸ '''Endocarditis'''
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| </font>
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| </div>
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| <div class="mw-customtoggle-table04" style="cursor: pointer; border-radius: 0 0 0 0; border: solid 1px #20538D; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: inset 0 1px 1px rgba(255, 255, 255, 0.5), 0 1px 1px rgba(0, 0, 0, 0.5); height: 30px; line-height: 30px; width: 225px; background: #4479BA; margin: 0 18px;">
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| <font color="#FFF">
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| ▸ '''Gastroenteritis'''
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| </font>
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| </div>
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| <div class="mw-customtoggle-table05" style="cursor: pointer; border-radius: 0 0 0 0; border: solid 1px #20538D; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: inset 0 1px 1px rgba(255, 255, 255, 0.5), 0 1px 1px rgba(0, 0, 0, 0.5); height: 30px; line-height: 30px; width: 225px; background: #4479BA; margin: 0 18px;">
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| <font color="#FFF">
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| ▸ '''Meningitis'''
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| </font>
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| </div>
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| <div class="mw-customtoggle-table06" style="cursor: pointer; border-radius: 0 0 5px 5px; border: solid 1px #20538D; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: inset 0 1px 1px rgba(255, 255, 255, 0.5), 0 1px 1px rgba(0, 0, 0, 0.5); height: 30px; line-height: 30px; width: 225px; background: #4479BA; margin: 0 18px;">
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| <font color="#FFF">
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| ▸ '''Rhombencephalitis'''
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| </font>
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| </div>
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| | valign=top |
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| {| class="mw-collapsible mw-collapsed" id="mw-customcollapsible-table01" style="background: #FFFFFF;"
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| | valign=top |
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| {| style="float: left; cellpadding=0; cellspacing= 0; width: 400px;"
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| ! style="height: 30px; line-height: 30px; background: #4479BA; border: 0px; font-size: 100%; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5);" align=center | {{fontcolor|#FFF|''Listeria monocytogenes'', Bacteremia<sup>¶</sup>}}
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| |-
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| | style="padding: 0 5px; font-size: 90%; background: #F5F5F5" align=center | '''''Preferred Regimen'''''
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| |-
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | ▸ '''''[[Ampicillin]] 2 g IV q4h'''''<BR> OR <BR> ▸ '''''[[Penicillin G]] 4 MU IV q4h'''''
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| |-
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | PLUS
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | ▸ '''''[[Gentamicin]] 2 mg/kg IV load, then 1.7 mg/kg IV q8h'''''
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| |-
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| | style="padding: 0 5px; font-size: 90%; background: #F5F5F5" align=center | '''''Alternative Regimen'''''
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| |-
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | ▸ '''''[[TMP/SMZ]] 10—20 mg/kg/day IV q6—12h''''' (TMP component)<BR> OR <BR> ▸ '''''[[Meropenem]] 2 g IV q8h'''''
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| |-
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| | style="padding: 0 5px; font-size: 90%; background: #F5F5F5" align=left | <sup>¶</sup><SMALL> '''Minimum duration of therapy: 2 weeks''' </SMALL>
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| |-
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| |}
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| |}
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| {| class="mw-collapsible mw-collapsed" id="mw-customcollapsible-table02" style="background: #FFFFFF;"
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| | valign=top |
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| {| style="float: left; cellpadding=0; cellspacing= 0; width: 400px;"
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| ! style="height: 30px; line-height: 30px; background: #4479BA; border: 0px; font-size: 100%; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5);" align=center | {{fontcolor|#FFF|''Listeria monocytogenes'', Brain Abscess<sup>†</sup>}}
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| |-
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| | style="padding: 0 5px; font-size: 90%; background: #F5F5F5" align=center | '''''Preferred Regimen'''''
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| |-
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | ▸ '''''[[Ampicillin]] 2 g IV q4h'''''<BR> OR <BR> ▸ '''''[[Penicillin G]] 4 MU IV q4h'''''
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| |-
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | PLUS
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| |-
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | ▸ '''''[[Gentamicin]] 2 mg/kg IV load, then 1.7 mg/kg IV q8h'''''
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| |-
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| | style="padding: 0 5px; font-size: 90%; background: #F5F5F5" align=center | '''''Alternative Regimen'''''
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| |-
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | ▸ '''''[[TMP/SMZ]] 10—20 mg/kg/day IV q6—12h''''' (TMP component)<BR> OR <BR> ▸ '''''[[Meropenem]] 2 g IV q8h'''''
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| | style="padding: 0 5px; font-size: 90%; background: #F5F5F5" align=left | <sup>†</sup><SMALL> '''Minimum duration of therapy: 6 weeks''' </SMALL>
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| |-
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| |}
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| |}
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| {| class="mw-collapsible mw-collapsed" id="mw-customcollapsible-table03" style="background: #FFFFFF;"
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| | valign=top |
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| {| style="float: left; cellpadding=0; cellspacing= 0; width: 400px;"
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| ! style="height: 30px; line-height: 30px; background: #4479BA; border: 0px; font-size: 100%; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5);" align=center | {{fontcolor|#FFF|''Listeria monocytogenes'', Endocarditis<sup>§</sup>}}
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| |-
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| | style="padding: 0 5px; font-size: 90%; background: #F5F5F5" align=center | '''''Preferred Regimen'''''
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| |-
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | ▸ '''''[[Ampicillin]] 2 g IV q4h'''''<BR> OR <BR> ▸ '''''[[Penicillin G]] 4 MU IV q4h'''''
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| |-
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | PLUS
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| |-
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | ▸ '''''[[Gentamicin]] 2 mg/kg IV load, then 1.7 mg/kg IV q8h'''''
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| |-
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| | style="padding: 0 5px; font-size: 90%; background: #F5F5F5" align=center | '''''Alternative Regimen'''''
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| |-
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | ▸ '''''[[TMP/SMZ]] 10—20 mg/kg/day IV q6—12h''''' (TMP component)<BR> OR <BR> ▸ '''''[[Meropenem]] 2 g IV q8h'''''
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| | style="padding: 0 5px; font-size: 90%; background: #F5F5F5" align=left | <sup>§</sup><SMALL> '''Minimum duration of therapy: 4—6 weeks''' </SMALL>
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| |-
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| |}
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| |}
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| {| class="mw-collapsible mw-collapsed" id="mw-customcollapsible-table04" style="background: #FFFFFF;"
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| | valign=top |
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| {| style="float: left; cellpadding=0; cellspacing= 0; width: 400px;"
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| ! style="height: 30px; line-height: 30px; background: #4479BA; border: 0px; font-size: 100%; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5);" align=center | {{fontcolor|#FFF|''Listeria monocytogenes'', Gastroenteritis}}
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| |-
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| | style="padding: 0 5px; font-size: 90%; background: #F5F5F5" align=center | '''''Preferred Regimen'''''
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| |-
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | ▸ Antimicrobial therapy is <u>'''not'''</u> warranted in most cases.
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| | style="padding: 0 5px; font-size: 90%; background: #F5F5F5" align=center | '''''Alternative Regimen''''' <BR> <SMALL> (For Outbreaks and Invasive Diseases) </SMALL>
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| |-
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | ▸ '''''[[Ampicillin]] 500 mg PO q6h x 5 days'''''<BR> OR <BR> ▸ '''''[[TMP/SMZ]] 160/800 mg PO q12h x 5 days'''''
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| |-
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| |}
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| |}
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| {| class="mw-collapsible mw-collapsed" id="mw-customcollapsible-table05" style="background: #FFFFFF;"
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| | valign=top |
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| {| style="float: left; cellpadding=0; cellspacing= 0; width: 400px;"
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| ! style="height: 30px; line-height: 30px; background: #4479BA; border: 0px; font-size: 100%; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5);" align=center | {{fontcolor|#FFF|''Listeria monocytogenes'', Meningitis<sup>‡</sup>}}
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| |-
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| | style="padding: 0 5px; font-size: 90%; background: #F5F5F5" align=center | '''''Preferred Regimen'''''
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| |-
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | ▸ '''''[[Ampicillin]] 2 g IV q4h'''''<BR> OR <BR> ▸ '''''[[Penicillin G]] 4 MU IV q4h'''''
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| |-
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | PLUS
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| |-
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | ▸ '''''[[Gentamicin]] 2 mg/kg IV load, then 1.7 mg/kg IV q8h'''''
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| |-
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| | style="padding: 0 5px; font-size: 90%; background: #F5F5F5" align=center | '''''Alternative Regimen'''''
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| |-
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | ▸ '''''[[TMP/SMZ]] 10—20 mg/kg/day IV q6—12h''''' (TMP component)<BR> OR <BR> ▸ '''''[[Meropenem]] 2 g IV q8h'''''
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| | style="padding: 0 5px; font-size: 90%; background: #F5F5F5" align=left | <sup>‡</sup><SMALL> '''Minimum duration of therapy: 3 weeks''' </SMALL>
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| |-
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| |}
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| |}
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| {| class="mw-collapsible mw-collapsed" id="mw-customcollapsible-table06" style="background: #FFFFFF;"
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| | valign=top |
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| {| style="float: left; cellpadding=0; cellspacing= 0; width: 400px;"
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| ! style="height: 30px; line-height: 30px; background: #4479BA; border: 0px; font-size: 100%; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5);" align=center | {{fontcolor|#FFF|''Listeria monocytogenes'', Rhombencephalitis<sup>†</sup>}}
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| |-
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| | style="padding: 0 5px; font-size: 90%; background: #F5F5F5" align=center | '''''Preferred Regimen'''''
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| |-
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | ▸ '''''[[Ampicillin]] 2 g IV q4h'''''<BR> OR <BR> ▸ '''''[[Penicillin G]] 4 MU IV q4h'''''
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| |-
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | PLUS
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | ▸ '''''[[Gentamicin]] 2 mg/kg IV load, then 1.7 mg/kg IV q8h'''''
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| |-
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| | style="padding: 0 5px; font-size: 90%; background: #F5F5F5" align=center | '''''Alternative Regimen'''''
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| |-
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | ▸ '''''[[TMP/SMZ]] 10—20 mg/kg/day IV q6—12h''''' (TMP component)<BR> OR <BR> ▸ '''''[[Meropenem]] 2 g IV q8h'''''
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| | style="padding: 0 5px; font-size: 90%; background: #F5F5F5" align=left | <sup>†</sup><SMALL> '''Minimum duration of therapy: 6 weeks''' </SMALL>
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| |-
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| |}
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| |}
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| |}</div>
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| <SMALL><SMALL><SMALL><SMALL><SMALL>Adapted from ''Clin Infect Dis. 1997;24(1):1-9.'',<ref>{{Cite journal | issn = 1058-4838 | volume = 24 | issue = 1 | pages = 1–9; quiz 10-11 | last = Lorber | first = B. | title = Listeriosis | journal = Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America | date = 1997-01 | pmid = 8994747 }}</ref> ''Clin Infect Dis. 2005;40(9):1327-32.'',<ref>{{Cite journal | doi = 10.1086/429324 | issn = 1537-6591 | volume = 40 | issue = 9 | pages = 1327–1332 | last = Ooi | first = Say Tat | coauthors = Bennett Lorber | title = Gastroenteritis due to Listeria monocytogenes | journal = Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America | date = 2005-05-01 | pmid = 15825036 }}</ref> and ''Clin Infect Dis. 2004;39(9):1267-84.''<ref>{{Cite journal | doi = 10.1086/425368 | issn = 1537-6591 | volume = 39 | issue = 9 | pages = 1267–1284 | last = Tunkel | first = Allan R. | coauthors = Barry J. Hartman, Sheldon L. Kaplan, Bruce A. Kaufman, Karen L. Roos, W. Michael Scheld, Richard J. Whitley | title = Practice guidelines for the management of bacterial meningitis | journal = Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America | date = 2004-11-01 | pmid = 15494903 }}</ref></SMALL></SMALL></SMALL></SMALL></SMALL>
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| ===Antimicrobial regimen=== | | ===Antimicrobial regimen=== |
| *1. '''Meningitis''' <ref>{{cite book | last = Bartlett | first = John | title = Johns Hopkins ABX guide : diagnosis and treatment of infectious diseases | publisher = Jones and Bartlett Learning | location = Burlington, MA | year = 2012 | isbn = 978-1449625580 }}</ref> | | *1. '''Meningitis''' <ref>{{cite book | last = Bartlett | first = John | title = Johns Hopkins ABX guide : diagnosis and treatment of infectious diseases | publisher = Jones and Bartlett Learning | location = Burlington, MA | year = 2012 | isbn = 978-1449625580 }}</ref> |