Lipoprotein-associated phospholipase A2 (Lp-PLA2)

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme that can modify low-density lipoproteins and may be involved in atherogenesis and the risk of coronary artery disease. In a nested case-control study, patients in the highest quintile of Lp-PLA2 levels had nearly twice the odds of coronary events compared with patients in the lowest quintile.