Lipoma pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Lipomas are circumscribed encapsulated soft masses, made nearly entirely of fat. Solid components may present in some cases.

Pathophysiology

• Simple lipomas are circumscribed encapsulated soft masses, made nearly entirely of fat.
• Occasionally solid components will be present (blood vessels, muscle fibres, fibrous septae, and fat necrosis), which need to be carefully assessed to ensure that these do not represent a more aggressive component.
• Histology demonstrates mature adipocytes with no cellular atypia or pleomorphism.

References

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