Linitis plastica causes: Difference between revisions

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{{Linitis plastica}}
{{Linitis plastica}}
{{CMG}}{{AE}} {{STM}}
{{CMG}};{{AE}}{{HM}}


==Overview==
==Overview==
The most common cause of linitis plastica is scirrhous [[adenocarcinoma]]. Linitis plastica may be caused by germline mutations in the ''CDH1'' ([[E-cadherin]]) gene.<ref name="RobbinsBasic">Robbins Basic Pathology, 8th Edition</ref><ref name=st>Linitis plastica. Radiopedia. http://radiopaedia.org/articles/linitis-plastica Accessed on January 20, 2016</ref>
Linitis plastica may develop as a primary or secondary pathology. As a primary pathology, linitis plastica may be due to defective intracellular adhesions caused by germline truncations mutation in [[CDH1 (gene)|CDH1]] gene. [[CDH1 (gene)|CDH1]] gene codes for [[Cadherin|E-cadherin]] adhesion protein. Secondarily, linitis plastica may be caused by [[metastasis]] to the [[stomach]] or by the [[Lye|ingestion of lye]].


==Causes==
==Causes==
*The most common cause of linitis plastica is scirrhous adenocarcinoma.
===Primary Causes===
*Linitis plastica may be caused by germline mutations in the ''CDH1'' ([[E-cadherin]]) gene.<ref name="RobbinsBasic">Robbins Basic Pathology, 8th Edition</ref><ref name=st>Linitis plastica. Radiopedia. http://radiopaedia.org/articles/linitis-plastica Accessed on January 20, 2016</ref>
*Linitis plastica can develop in an autosomal dominant pattern by a mutation in the CDH1 gene.<ref name="pmid14630673">{{cite journal |vauthors=Graziano F, Humar B, Guilford P |title=The role of the E-cadherin gene (CDH1) in diffuse gastric cancer susceptibility: from the laboratory to clinical practice |journal=Ann. Oncol. |volume=14 |issue=12 |pages=1705–13 |year=2003 |pmid=14630673 |doi= |url=}}</ref>
* [[Somatic]] [[mutations]] in the ''CDH1'' [[gene]]  can occur by:
**Hypermethylation
**[[Loss of heterozygosity]]
**Silencing mutations
 
===Secondary causes===
*[[Lye]] ingestion
*[[Metastasis|Metastatic]] infiltration of the stomach by:
**[[Lung cancer]]
**[[Breast cancer]]
**[[Non-Hodgkin lymphoma]]<ref name="pmid8888226">{{cite journal |vauthors=Levine MS, Pantongrag-Brown L, Aguilera NS, Buck JL, Buetow PC |title=Non-Hodgkin lymphoma of the stomach: a cause of linitis plastica |journal=Radiology |volume=201 |issue=2 |pages=375–8 |year=1996 |pmid=8888226 |doi=10.1148/radiology.201.2.8888226 |url=}}</ref>


==References==
==References==

Latest revision as of 17:07, 8 January 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Hadeel Maksoud M.D.[2]

Overview

Linitis plastica may develop as a primary or secondary pathology. As a primary pathology, linitis plastica may be due to defective intracellular adhesions caused by germline truncations mutation in CDH1 gene. CDH1 gene codes for E-cadherin adhesion protein. Secondarily, linitis plastica may be caused by metastasis to the stomach or by the ingestion of lye.

Causes

Primary Causes

Secondary causes

References

  1. Graziano F, Humar B, Guilford P (2003). "The role of the E-cadherin gene (CDH1) in diffuse gastric cancer susceptibility: from the laboratory to clinical practice". Ann. Oncol. 14 (12): 1705–13. PMID 14630673.
  2. Levine MS, Pantongrag-Brown L, Aguilera NS, Buck JL, Buetow PC (1996). "Non-Hodgkin lymphoma of the stomach: a cause of linitis plastica". Radiology. 201 (2): 375–8. doi:10.1148/radiology.201.2.8888226. PMID 8888226.


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