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'''For patient information click [[Leukemia (patient information)|here]]'''
__NOTOC__
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{{DiseaseDisorder infobox |
{{DiseaseDisorder infobox |
   Name          = Leukemia |
   Name          = Leukemia |
  ICD10          = {{ICD10|C|91||c|81}}-{{ICD10|C|95||c|81}} |
  ICD9          = {{ICD9|208.9}} |
  ICDO          = 9800-9940 |
   Image          = acute_leukemia-ALL.jpg |
   Image          = acute_leukemia-ALL.jpg |
   Caption        = A Wright's stained bone marrow aspirate smear of patient with precursor B-cell acute lymphoblastic leukemia.|
   Caption        = A Wright's stained bone marrow aspirate smear of patient with precursor B-cell acute lymphoblastic leukemia.|
   OMIM          = |
   }}
  MedlinePlus    = |
{{Leukemia}}
  eMedicineSubj  = |
  eMedicineTopic = |
  DiseasesDB    = 7431 |
  MeshID        = D007938 |
}}


'''For patient information click [[Leukemia (patient information)|here]]'''


{{CMG}}
{{CMG}}
{{Leukemia}}
 
{{Editor Join}}
{{SK}} Leukaemia


==[[Leukemia overview|Overview]]==
==[[Leukemia overview|Overview]]==


==[[Leukemia history and symptoms|History & Symptoms]]==
==[[Leukemia historical perspective|Historical Perspective]]==


==Causes and risk factors==
==[[Leukemia classification|Classification]]==
There is no single known cause for all of the different types of leukemia. The different leukemias likely have different causes, and very little is certain about what causes them. Researchers have strong suspicions about four possible causes:


* natural or artificial ionizing radiation
==[[Leukemia pathophysiology|Pathophysiology]]==
* certain kinds of chemicals
* some viruses
* genetic predispositions


Leukemia, like other cancers, result from [[somatic mutation]]s in the [[DNA]] which activate [[oncogene]]s or deactivate [[tumor suppressor gene]]s, and disrupt the regulation of cell death, differentiation or division.  These mutations may occur spontaneously or as a result of exposure to [[ionizing radiation|radiation]] or [[carcinogen]]ic substances and are likely to be influenced by genetic factors.  Cohort and case-control studies have linked exposure to [[petrochemicals]], such as [[benzene]], and hair dyes to the development of some forms of leukemia.
==[[Leukemia causes|Causes]]==


[[virus (biology)|Viruses]] have also been linked to some forms of leukemia.  For example, certain cases of ALL are associated with viral infections by either the [[human immunodeficiency virus]] (HIV, responsible for [[AIDS]]) or [[human T-lymphotropic virus]] (HTLV-1 and -2, causing [[adult T-cell leukemia/lymphoma]]).
==[[Leukemia differential diagnosis|Differentiating Leukemia from other Diseases]]==


[[Fanconi anemia]] is also a risk factor for developing [[Acute myeloid leukemia|acute myelogenous leukemia]].
==[[Leukemia epidemiology and demographics|Epidemiology and Demographics]]==


Until the cause or causes of leukemia are found, there is no way to prevent the disease.  Even when the causes become known, they may prove to be things which are not readily controllable, such as naturally occurring background radiation, and therefore not especially helpful for prevention purposes.
==[[Leukemia risk factors|Risk Factors]]==


==References==
==[[Leukemia screening|Screening]]==
{{Reflist|2}}


== Research ==
==[[Leukemia natural history, complications and prognosis|Natural History, Complications and Prognosis]]==


Significant research into the causes, diagnosis, treatment, and prognosis of leukemia is being done.  Hundreds of [[clinical trials]] are being planned or conducted at any given time.  Studies may focus on effective means of treatment, better ways of treating the disease, improving the quality of life for patients, or appropriate care in remission or after cure.
==Diagnosis==


==External links==
[[Leukemia staging | Staging]] | [[Leukemia history and symptoms| History and Symptoms]] | [[Leukemia physical examination | Physical Examination]] | [[Leukemia laboratory studies | Laboratory Findings]] | [[Leukemia electrocardiogram|Electrocardiogram]] | [[Leukemia chest x ray|Chest X Ray]] | [[Leukemia CT|CT]] |  [[Leukemia MRI|MRI]] | [[Leukemia echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Leukemia other imaging findings|Other Imaging Findings]] | [[Leukemia other diagnostic studies|Other Diagnostic Studies]]
'''Images of leukemias'''
 
*[http://www.healthsystem.virginia.edu/internet/hematology/HessIDB/stages-of-acute-leukemia.cfm UVA Healthsystem] -- Images of acute leukemias by stage
==Treatment==
 
[[Leukemia medical therapy|Medical Therapy]] | [[Leukemia surgery|Surgery]] | [[Leukemia primary prevention|Primary Prevention]]  | [[Leukemia cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Leukemia future or investigational therapies|Future or Investigational Therapies]]
 
==Case Studies==
[[Leukemia case study one | Case #1]]


'''Research organizations'''
*[http://www.tacl.us/ The Therapeutic Advances in Childhood Leukemia (TACL) Consortium] -- US research group
*[http://atlasgeneticsoncology.org/Educ/Hempat_e.html "Chromosomes, Leukaemias, Solid Tumors, Hereditary Cancers"] in AtlasGeneticsOncology.


{{Blood}}
{{Blood}}
{{Hematological malignancy histology}}
{{Hematological malignancy histology}}
[[af:Leukemie]]
 
[[ar:ابيضاض الدم]]
[[bs:Leukemija]]
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[[da:Leukæmi]]
[[de:Leukämie]]
[[es:Leucemia]]
[[eo:Leŭkemio]]
[[fr:Leucémie]]
[[ko:백혈병]]
[[id:Leukemia]]
[[ia:Leucemia]]
[[it:Leucemia]]
[[he:לוקמיה]]
[[la:Leucaemia]]
[[lt:Leukemija]]
[[hu:Leukémia]]
[[mk:Леукемија]]
[[ms:Leukemia]]
[[nl:Leukemie]]
[[ja:白血病]]
[[no:Leukemi]]
[[nn:Leukemi]]
[[pl:Białaczka]]
[[pt:Leucemia]]
[[ru:Лейкозы]]
[[sq:Leukoza]]
[[simple:Leukemia]]
[[sk:Leukémia]]
[[sr:Леукемија]]
[[su:Leukemia]]
[[fi:Leukemia]]
[[sv:Leukemi]]
[[th:มะเร็งเม็ดเลือดขาว]]
[[vi:Ung thư bạch cầu]]
[[tr:Lösemi]]
[[uk:Лейкоз]]
[[yi:לאקימיע]]
[[bat-smg:Leukemėjė]]
[[zh:白血病]]
{{WikiDoc Help Menu}}
{{WikiDoc Help Menu}}
{{WikiDoc Sources}}
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[[Category:primary care]]
[[Category:Disease]]
[[Category:Disease]]
[[Category:Hematology]]
[[Category:Hematology]]

Revision as of 14:56, 23 July 2015

Template:DiseaseDisorder infobox

Leukemia Microchapters

Home

Patient Information

Overview

Classification

AML
CML
ALL
CLL

Differentiating Leukemia from other Diseases

Epidemiology and Demographics

Prognosis

For patient information click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Leukaemia

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Leukemia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging | History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | Chest X Ray | CT | MRI | Echocardiography or Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1


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