Lateral medullary syndrome: Difference between revisions

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{{CMG}}
{{CMG}}


{{SK}} Wallenberg's syndrome; posterior inferior cerebellar artery syndrome
{{SK}} Wallenberg's syndrome; posterior inferior cerebellar artery syndrome (PICA)


==Overview==
==Overview==  
Lateral medullary syndrome is a neurological condition caused by a stroke in the vertebral or posterior inferior [[cerebellar artery]] of the [[brain stem]].


==Historical Perspective==
==Historical Perspective==
This syndrome was first described in 1808 by Gaspard Viesseux,<ref>{{WhoNamedIt|synd|1778}}</ref>. First descriptions by Adolf Wallenberg were in 1895 (clinical) and 1901 (autopsy findings).
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==Pathophysiology==
==Pathophysiology==
The syndrome results from occlusion of the [[posterior inferior cerebellar artery]] ([[PICA]]) or one of its branches or of the [[vertebral artery]], in which the lateral part of the [[medulla oblongata]] infarcts.
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==Natural History, Complications and Prognosis==
==Natural History, Complications and Prognosis==
The outlook for someone with lateral medullary syndrome depends upon the size and location of the area of the brain stem damaged by the stroke.  Some individuals may see a decrease in their symptoms within weeks or months.  Others may be left with significant neurological disabilities for years after the initial symptoms appeared.
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== Diagnosis ==
== Diagnosis ==
===Symptoms===
===Symptoms===
Symptoms include
Symptoms include:
*[[Ageusia]] or [[loss of taste]] on one side of the [[tongue]]
*[[Ageusia]] or [[loss of taste]] on one side of the [[tongue]]
*[[Ataxia]] or [[incoordination]]
*[[Ataxia]] or [[incoordination]]
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*[[Facial pain]]
*[[Facial pain]]
*[[Falling]]
*[[Falling]]
*Palatal myoclonus
*[[Hiccups]]
*[[Hiccups]]
*[[Hoarseness]]
*[[Hoarseness]]
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*[[Nystagmus]] or [[rapid involuntary movements of the eyes]]
*[[Nystagmus]] or [[rapid involuntary movements of the eyes]]
*[[Nausea and vomiting]]
*[[Nausea and vomiting]]
*Sense that the world is tilting
*[[Vertigo_(medical)|Vertigo]]
*[[Vertigo_(medical)|Vertigo]]


===Physical Examination===
===Physical Examination===
====Neurologic====
====Neurologic====
*Sensory deficits affecting the trunk and extremities on the opposite side of the infarct
*Contralateral sensory deficits (pain and temperature sensation) affecting the trunk and extremities  
*Sensory and motor deficits affecting the face and cranial nerves on the same side with the infarct.
*Ipsilateral sensory  deficits (pain and temperature sensation) affecting the face and cranial nerves  
**absence of pain on the ipsilateral side of the face, as well as an absent [[corneal reflex]] (Damage to the spinal [[trigeminal nucleus]])
*[[Ataxia]]
*[[Ataxia]]
*[[Nystagmus]],
*[[Nystagmus]],
*[[Horner's syndrome]]
*[[Horner's syndrome]]
*Damage to the spinal [[trigeminal nucleus]] causes absence of pain on the ipsilateral side of the face, as well as an absent [[corneal reflex]]
*Ipsilateral vocal fold paralysis
*Palatal and pharyngeal paresis
*


===MRI===
===MRI===
[[Image:Wallenberganon_Image001.jpg|thumb|left|Clinical B1000 diffusion weighted MRI image showing an acute left sided dorsal lateral medullary infarct]]
[[Image:Wallenberganon_Image001.jpg|thumb|left|Clinical B1000 diffusion weighted MRI image showing an acute left sided dorsal lateral medullary infarct]]
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{{clr}}


===Localization of the Lesion===
===Localization of the Lesion===
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==Treatment==
==Treatment==
Treatment for lateral medullary syndrome is symptomatic. A feeding tube may be necessary if swallowing is very difficult.  Speech/swallowing therapy  may be beneficial. In some cases, medication may be used to reduce or eliminate pain.  Some doctors report that the anti-epileptic drug gabapentin appears to be an effective medication for individuals with chronic pain.
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==References==
==References==
<references/>
<references />


==External links==
==External links==

Revision as of 23:08, 25 July 2020

Lateral medullary syndrome
The three major arteries of the cerebellum: the SCA, AICA, and PICA. (Posterior inferior cerebellar artery is PICA.)
ICD-10 G46.3
DiseasesDB 10449
MeSH D014854

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Wallenberg's syndrome; posterior inferior cerebellar artery syndrome (PICA)

Overview

Historical Perspective


Pathophysiology


Natural History, Complications and Prognosis


Diagnosis

Symptoms

Symptoms include:

Physical Examination

Neurologic

  • Contralateral sensory deficits (pain and temperature sensation) affecting the trunk and extremities
  • Ipsilateral sensory deficits (pain and temperature sensation) affecting the face and cranial nerves
  • Ataxia
  • Nystagmus,
  • Horner's syndrome
  • Ipsilateral vocal fold paralysis
  • Palatal and pharyngeal paresis

MRI

Clinical B1000 diffusion weighted MRI image showing an acute left sided dorsal lateral medullary infarct







Localization of the Lesion

Dysfunction Effects
lateral spinothalamic tract contralateral deficits in pain and temperature sensation from body
spinal trigeminal nucleus ipsilateral loss of pain and temperature sensation from face
nucleus ambiguus (which affects vagus X and glossopharyngeal nerves IX) dysphagia, hoarseness, diminished gag reflex
vestibular system vertigo, diplopia, nystagmus, vomiting
descending sympathetic fibers ipsilateral Horner's syndrome
central tegmental tract palatal myoclonus

Treatment


References


External links

Template:Diseases of the nervous system Template:Lesions of spinal cord and brainstem

de:Wallenberg-Syndrom Template:WH Template:WS