Laron syndrome (patient information)

	WikiDoc Resources for Laron syndrome (patient information)
Articles
Most recent articles on Laron syndrome (patient information) Most cited articles on Laron syndrome (patient information) Review articles on Laron syndrome (patient information) Articles on Laron syndrome (patient information) in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Laron syndrome (patient information) Images of Laron syndrome (patient information) Photos of Laron syndrome (patient information) Podcasts & MP3s on Laron syndrome (patient information) Videos on Laron syndrome (patient information)
Evidence Based Medicine
Cochrane Collaboration on Laron syndrome (patient information) Bandolier on Laron syndrome (patient information) TRIP on Laron syndrome (patient information)
Clinical Trials
Ongoing Trials on Laron syndrome (patient information) at Clinical Trials.gov Trial results on Laron syndrome (patient information) Clinical Trials on Laron syndrome (patient information) at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Laron syndrome (patient information) NICE Guidance on Laron syndrome (patient information) NHS PRODIGY Guidance FDA on Laron syndrome (patient information) CDC on Laron syndrome (patient information)
Books
Books on Laron syndrome (patient information)
News
Laron syndrome (patient information) in the news Be alerted to news on Laron syndrome (patient information) News trends on Laron syndrome (patient information)
Commentary
Blogs on Laron syndrome (patient information)
Definitions
Definitions of Laron syndrome (patient information)
Patient Resources / Community
Patient resources on Laron syndrome (patient information) Discussion groups on Laron syndrome (patient information) Patient Handouts on Laron syndrome (patient information) Directions to Hospitals Treating Laron syndrome (patient information) Risk calculators and risk factors for Laron syndrome (patient information)
Healthcare Provider Resources
Symptoms of Laron syndrome (patient information) Causes & Risk Factors for Laron syndrome (patient information) Diagnostic studies for Laron syndrome (patient information) Treatment of Laron syndrome (patient information)
Continuing Medical Education (CME)
CME Programs on Laron syndrome (patient information)
International
Laron syndrome (patient information) en Espanol Laron syndrome (patient information) en Francais
Business
Laron syndrome (patient information) in the Marketplace Patents on Laron syndrome (patient information)
Experimental / Informatics
List of terms related to Laron syndrome (patient information)

	Laron syndrome;
	Growth hormone
ICD-10	E34.3
ICD-9	259.4
OMIM	262500 245590
DiseasesDB	7262
MeSH	D046150

For the WikiDoc page for this topic, click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Jinhui Wu, MD

Overview

Laron syndrome is a rare genetic disease where the body has sufficient growth hormones but lacks receptors to utilize the hormone and hence dwarfism results. It was first reported by Zvi Laron and colleagues in Israel in 1966. Researches demonstrate that gene mutations in growth hormone receptor may involve in the disease. The principal feature of Laron syndrome is abnormally short stature. Blood hormone tests, bone age test and cranial MRI scan may help the diagnosis. The only effective treatment for patients with Laron syndrome is administration of insulinlike growth factor-1 (IGF-1). Many patients appear good with the treatment.

How do I know if I have Laron syndrome and what are the symptoms of Laron syndrome?

The principal feature of Laron syndrome is abnormally short stature

Short hands and short feet
Unusual facies: Prominent forehead, deep-set eyes, blue sclera, saddle nose and depressed nose bridge
Proportionally larger head and abnormal skull growth
High-pitched voice
Reduced or normal intelligence
Delayed bone age
Delayed menstruation onset in girls
Small penis in boys
Delayed sexual development
Childlike proportions in adults
Obesity

Who is at risk for Laron syndrome?

Clinical investigations have demonstrated that the cause of Laron syndrome is associated with gene mutations in growth hormone receptor.

How to know you have Laron syndrome?

Blood hormone tests, including the level of growth hormone (GH), insulinlike growth factor-1 (IGF-I), insulinlike growth factor binding protein-3 (IGFBP-3), basal GH, and GH binding protein (GHBP). Other tests invlove an IGF/IGFBP-3 generation test and provocative GH test. The doctor will manage the test and explain the results to you.
Blood glucose and lipid test: It may show hypoglycemia and hypercholesterolemia in patients with Laron syndrome.
A bone age test: For children suspect Laron syndrome, dual energy x-ray absorptiometry (DEXA) scans can be used to determine bone age.
Cranial MRI: The goal of cranial MRI is to rule out growth hormone deficiency caused by other damages, such as tumor or injure in hypothalamus and pituitary glands.

When to seek urgent medical care?

Call your health care provider if your child seems delayed growth.

Treatment options

The only effective treatment currently available for patients with Laron syndrome is administration of insulinlike growth factor-1 (IGF-1). For infants patients, they may require more frequent feedings to avoid hypoglycemia. Regular blood sugar monitoring is necessary for some patients with Laron syndrome and for all patients with Laron syndrome taking IGF-I therapy.

Diseases with similar symptoms

Intrauterine growth retardation
Constitutional delay of growth
Idiopathic short stature
Nutritional growth retardation
Psychosocial short stature

Where to find medical care for Laron syndrome?

Directions to Hospitals Treating Laron syndrome

Prevention of Laron syndrome

Genetic counseling may be an important aspect of education and prevention.

What to expect (Outook/Prognosis)?

Prognosis of Laron syndrome is not bad. Alert hypoglycemia is very important.

Sources

Template:WH Template:WS