Laron syndrome: Difference between revisions

	Laron syndrome Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Laron Syndrome from other Diseases
Epidemiology and Demographics
Risk Factors
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms
Physical Examination
Laboratory Findings
CT
MRI
Echocardiography or Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Laron syndrome On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Laron syndrome All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Laron syndrome
CDC on Laron syndrome
Laron syndrome in the news
Blogs on Laron syndrome
Directions to Hospitals Treating Laron syndrome
Risk calculators and risk factors for Laron syndrome

	Laron syndrome;
	Growth hormone
ICD-10	E34.3
ICD-9	259.4
OMIM	262500 245590
DiseasesDB	7262
MeSH	D046150

VisualWikitext

Revision as of 19:59, 19 September 2012

For patient information click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Assosciate Editor(s)-In-Chief: Prashanth Saddala M.B.B.S

Synonyms and keywords: Growth Harmone Receptor Deficiency; Growth hormone insensitivity syndrome; pituitary dwarfism II; Laron syndrome due to postreceptor defect; growth hormone insensitivity due to postreceptor defect; Laron-type dwarfism

Diagnosis

Physical Examination

Physical exam findings include:

Treatment

Treatment may include administration of IGF-1.

References

Template:WikiDoc Sources

@@ Line 21: / Line 21: @@
 ==Diagnosis==
-===Symptoms===
-The principal feature of Laron syndrome is abnormally short stature ([[dwarfism]]).
-Symptoms include:
-*Truncal [[obesity]]<ref name="pmid16817829">{{cite journal |author=Laron Z, Ginsberg S, Lilos P, Arbiv M, Vaisman N |title=Body composition in untreated adult patients with Laron syndrome (primary GH insensitivity) |journal=Clin. Endocrinol. (Oxf) |volume=65 |issue=1 |pages=114-7 |year=2006 |pmid=16817829 |doi=10.1111/j.1365-2265.2006.02558.x}}</ref>
-*[[Seizures]] are frequently secondary to [[hypoglycemia]].
-*Some genetic variations have an impact upon intellectual capacity.<ref name="pmid16372230">{{cite journal |author=Shevah O, Kornreich L, Galatzer A, Laron Z |title=The intellectual capacity of patients with Laron syndrome (LS) differs with various molecular defects of the growth hormone receptor gene. Correlation with CNS abnormalities |journal=Horm. Metab. Res. |volume=37 |issue=12 |pages=757-60 |year=2005 |pmid=16372230 |doi=10.1055/s-2005-921097}}</ref>
 ===Physical Examination===
 Physical exam findings include:


Laron syndrome
Growth hormone
ICD-10	E34.3
ICD-9	259.4
OMIM	262500 245590
DiseasesDB	7262
MeSH	D046150