Laron syndrome: Difference between revisions

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Epidemiology and Demographics
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	Laron syndrome;
	Growth hormone
ICD-10	E34.3
ICD-9	259.4
OMIM	262500 245590
DiseasesDB	7262
MeSH	D046150

VisualWikitext

Latest revision as of 20:16, 19 September 2012

For patient information click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Assosciate Editor(s)-In-Chief: Prashanth Saddala M.B.B.S

Synonyms and keywords: Growth Harmone Receptor Deficiency; Growth hormone insensitivity syndrome; pituitary dwarfism II; Laron syndrome due to postreceptor defect; growth hormone insensitivity due to postreceptor defect; Laron-type dwarfism

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Laron Syndrome from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

Treatment

Case Studies

Case #1

Template:WikiDoc Sources

@@ Line 20: / Line 20: @@
 Laron syndrome due to postreceptor defect; growth hormone insensitivity due to postreceptor defect; Laron-type dwarfism
-==Epidemiology and Demographics==
+==[[Laron syndrome overview|Overview]]==
-The majority of reported cases have been of Mediterranean or semitic origin, with numerous patients in Israel, Ecuador, Turkey and in the Bahamas.
-==Diagnosis==
-===Symptoms===
-The principal feature of Laron syndrome is abnormally short stature ([[dwarfism]]).
-Symptoms include:
-*Truncal [[obesity]]<ref name="pmid16817829">{{cite journal |author=Laron Z, Ginsberg S, Lilos P, Arbiv M, Vaisman N |title=Body composition in untreated adult patients with Laron syndrome (primary GH insensitivity) |journal=Clin. Endocrinol. (Oxf) |volume=65 |issue=1 |pages=114-7 |year=2006 |pmid=16817829 |doi=10.1111/j.1365-2265.2006.02558.x}}</ref>
-*[[Seizures]] are frequently secondary to [[hypoglycemia]].
-*Some genetic variations have an impact upon intellectual capacity.<ref name="pmid16372230">{{cite journal |author=Shevah O, Kornreich L, Galatzer A, Laron Z |title=The intellectual capacity of patients with Laron syndrome (LS) differs with various molecular defects of the growth hormone receptor gene. Correlation with CNS abnormalities |journal=Horm. Metab. Res. |volume=37 |issue=12 |pages=757-60 |year=2005 |pmid=16372230 |doi=10.1055/s-2005-921097}}</ref>
-===Physical Examination===
-Physical exam findings include:
-*[[Prominent forehead]]
-*[[Depressed nasal bridge]]
-*[[Under-development of mandible]]
-*A [[Micropenis|very small penis]]
-==Treatment==
+==[[Laron syndrome historical perspective|Historical Perspective]]==
-Treatment may include administration of [[IGF-1]].
+==[[Laron syndrome classification|Classification]]==
+==[[Laron syndrome pathophysiology|Pathophysiology]]==
+==[[Laron syndrome causes|Causes]]==
+==[[Laron syndrome differential diagnosis|Differentiating Laron Syndrome from other Diseases]]==
+==[[Laron syndrome epidemiology and demographics|Epidemiology and Demographics]]==
+==[[Laron syndrome risk factors|Risk Factors]]==
+==[[Laron syndrome natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
-==References==
+==[[Laron syndrome diagnosis|Diagnosis]]==
-{{Reflist|2}}
+[[Laron syndrome history and symptoms|History and Symptoms]] | [[Laron syndrome physical examination|Physical Examination]] | [[Laron syndrome laboratory findings|Laboratory Findings]] | [[Laron syndrome CT|CT]] | [[Laron syndrome MRI|MRI]] | [[Laron syndrome echocardiography or ultrasound|Ultrasound]] | [[Laron syndrome other imaging findings|Other Imaging Findings]] | [[Laron syndrome other diagnostic studies|Other Diagnostic Studies]]
+==Treatment==
+[[Laron syndrome medical therapy|Medical Therapy]] | [[Laron syndrome surgery|Surgery]] | [[Laron syndrome primary prevention|Primary Prevention]] | [[Laron syndrome secondary prevention|Secondary Prevention]] | [[Laron syndrome cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Laron syndrome future or investigational therapies|Future or Investigational Therapies]]
+==Case Studies==
+:[[Laron syndrome case study one|Case #1]]


Laron syndrome
Growth hormone
ICD-10	E34.3
ICD-9	259.4
OMIM	262500 245590
DiseasesDB	7262
MeSH	D046150

Laron syndrome: Difference between revisions

Latest revision as of 20:16, 19 September 2012

Treatment

Case Studies

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