Laminin, alpha 2: Difference between revisions

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Latest revision as of 19:27, 2 September 2017

Laminin subunit alpha-2 is a protein that in humans is encoded by the LAMA2 gene.^[1]^[2]^[3]

Function

Laminin, an extracellular matrix protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene.^[3]

References

↑ Ehrig K, Leivo I, Argraves WS, Ruoslahti E, Engvall E (Jun 1990). "Merosin, a tissue-specific basement membrane protein, is a laminin-like protein". Proc Natl Acad Sci U S A. 87 (9): 3264–8. doi:10.1073/pnas.87.9.3264. PMC 53880. PMID 2185464.
↑ Vuolteenaho R, Nissinen M, Sainio K, Byers M, Eddy R, Hirvonen H, Shows TB, Sariola H, Engvall E, Tryggvason K (Feb 1994). "Human laminin M chain (merosin): complete primary structure, chromosomal assignment, and expression of the M and A chain in human fetal tissues". J Cell Biol. 124 (3): 381–94. doi:10.1083/jcb.124.3.381. PMC 2119934. PMID 8294519.
↑ ^3.0 ^3.1 "Entrez Gene: LAMA2 laminin, alpha 2 (merosin, congenital muscular dystrophy)".

Timpl R (1997). "Macromolecular organization of basement membranes". Curr. Opin. Cell Biol. 8 (5): 618–24. doi:10.1016/S0955-0674(96)80102-5. PMID 8939648.
Belkin AM, Stepp MA (2000). "Integrins as receptors for laminins". Microsc. Res. Tech. 51 (3): 280–301. doi:10.1002/1097-0029(20001101)51:3<280::AID-JEMT7>3.0.CO;2-O. PMID 11054877.
Jones KJ, Morgan G, Johnston H, et al. (2002). "The expanding phenotype of laminin α2 chain (merosin) abnormalities: case series and review". J. Med. Genet. 38 (10): 649–57. doi:10.1136/jmg.38.10.649. PMC 1734735. PMID 11584042.
Hori H, Kanamori T, Mizuta T, et al. (1995). "Human laminin M chain: epitope analysis of its monoclonal antibodies by immunoscreening of cDNA clones and tissue expression". J. Biochem. 116 (6): 1212–9. PMID 7535762.
Helbling-Leclerc A, Zhang X, Topaloglu H, et al. (1995). "Mutations in the laminin alpha 2-chain gene (LAMA2) cause merosin-deficient congenital muscular dystrophy". Nat. Genet. 11 (2): 216–8. doi:10.1038/ng1095-216. PMID 7550355.
Yamada H, Shimizu T, Tanaka T, et al. (1994). "Dystroglycan is a binding protein of laminin and merosin in peripheral nerve". FEBS Lett. 352 (1): 49–53. doi:10.1016/0014-5793(94)00917-1. PMID 7925941.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Zhang X, Vuolteenaho R, Tryggvason K (1996). "Structure of the human laminin alpha2-chain gene (LAMA2), which is affected in congenital muscular dystrophy". J. Biol. Chem. 271 (44): 27664–9. doi:10.1074/jbc.271.44.27664. PMID 8910357.
Squarzoni S, Villanova M, Sabatelli P, et al. (1997). "Intracellular detection of laminin alpha 2 chain in skin by electron microscopy immunocytochemistry: comparison between normal and laminin alpha 2 chain deficient subjects". Neuromuscul. Disord. 7 (2): 91–8. doi:10.1016/S0960-8966(96)00420-8. PMID 9131649.
Allamand V, Sunada Y, Salih MA, et al. (1997). "Mild congenital muscular dystrophy in two patients with an internally deleted laminin alpha2-chain". Hum. Mol. Genet. 6 (5): 747–52. doi:10.1093/hmg/6.5.747. PMID 9158149.
Durkin ME, Loechel F, Mattei MG, et al. (1997). "Tissue-specific expression of the human laminin alpha5-chain, and mapping of the gene to human chromosome 20q13.2-13.3 and to distal mouse chromosome 2 near the locus for the ragged (Ra) mutation". FEBS Lett. 411 (2–3): 296–300. doi:10.1016/S0014-5793(97)00686-8. PMID 9271224.
Mrowiec T, Melchar C, Górski A (1998). "HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium". Arch. Immunol. Ther. Exp. (Warsz.). 45 (2–3): 255–9. PMID 9597096.
Koch M, Olson PF, Albus A, et al. (1999). "Characterization and Expression of the Laminin γ3 Chain: A Novel, Non-Basement Membrane–associated, Laminin Chain". J. Cell Biol. 145 (3): 605–18. doi:10.1083/jcb.145.3.605. PMC 2185082. PMID 10225960.
Kuang W, Xu H, Vilquin JT, Engvall E (2000). "Activation of the lama2 gene in muscle regeneration: abortive regeneration in laminin alpha2-deficiency". Lab. Invest. 79 (12): 1601–13. PMID 10616210.
Pegoraro E, Fanin M, Trevisan CP, et al. (2000). "A novel laminin alpha2 isoform in severe laminin alpha2 deficient congenital muscular dystrophy". Neurology. 55 (8): 1128–34. doi:10.1212/wnl.55.8.1128. PMID 11071490.
McArthur CP, Wang Y, Heruth D, Gustafson S (2001). "Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53". Arch. Oral Biol. 46 (6): 545–55. doi:10.1016/S0003-9969(01)00014-0. PMID 11311202.

External links

GeneReviews/NCBI/NIH/UW entry on Congenital Muscular Dystrophy Overview
LOVD mutation database: LAMA2

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[pmid2185464-1] Ehrig K, Leivo I, Argraves WS, Ruoslahti E, Engvall E (Jun 1990). "Merosin, a tissue-specific basement membrane protein, is a laminin-like protein". Proc Natl Acad Sci U S A. 87 (9): 3264–8. doi:10.1073/pnas.87.9.3264. PMC 53880. PMID 2185464.

[pmid8294519-2] Vuolteenaho R, Nissinen M, Sainio K, Byers M, Eddy R, Hirvonen H, Shows TB, Sariola H, Engvall E, Tryggvason K (Feb 1994). "Human laminin M chain (merosin): complete primary structure, chromosomal assignment, and expression of the M and A chain in human fetal tissues". J Cell Biol. 124 (3): 381–94. doi:10.1083/jcb.124.3.381. PMC 2119934. PMID 8294519.

[entrez-3] 3.0 ^3.1 "Entrez Gene: LAMA2 laminin, alpha 2 (merosin, congenital muscular dystrophy)".

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Laminin subunit alpha-2''' is a [[protein]] that in humans is encoded by the ''LAMA2'' [[gene]].<ref name="pmid2185464">{{cite journal |vauthors=Ehrig K, Leivo I, Argraves WS, Ruoslahti E, Engvall E | title = Merosin, a tissue-specific basement membrane protein, is a laminin-like protein | journal = Proc Natl Acad Sci U S A | volume = 87 | issue = 9 | pages = 3264–8 |date=Jun 1990 | pmid = 2185464 | pmc = 53880 | doi =10.1073/pnas.87.9.3264  }}</ref><ref name="pmid8294519">{{cite journal |vauthors=Vuolteenaho R, Nissinen M, Sainio K, Byers M, Eddy R, Hirvonen H, Shows TB, Sariola H, Engvall E, Tryggvason K | title = Human laminin M chain (merosin): complete primary structure, chromosomal assignment, and expression of the M and A chain in human fetal tissues | journal = J Cell Biol | volume = 124 | issue = 3 | pages = 381–94 |date=Feb 1994 | pmid = 8294519 | pmc = 2119934 | doi =10.1083/jcb.124.3.381  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LAMA2 laminin, alpha 2 (merosin, congenital muscular dystrophy)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3908| accessdate = }}</ref>
-| update_page = yes
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-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Laminin, alpha 2 (merosin, congenital muscular dystrophy)
- | HGNCid = 6482
- | Symbol = LAMA2
- | AltSymbols =; LAMM
- | OMIM = 156225
- | ECnumber =
- | Homologene = 37306
- | MGIid = 99912
- | GeneAtlas_image1 = PBB_GE_LAMA2_205116_at_tn.png
- | GeneAtlas_image2 = PBB_GE_LAMA2_213519_s_at_tn.png
- | GeneAtlas_image3 = PBB_GE_LAMA2_216840_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}}
- | Component = {{GNF_GO|id=GO:0005604 |text = basement membrane}} {{GNF_GO|id=GO:0005606 |text = laminin-1 complex}} {{GNF_GO|id=GO:0031012 |text = extracellular matrix}}
- | Process = {{GNF_GO|id=GO:0007517 |text = muscle development}} {{GNF_GO|id=GO:0030155 |text = regulation of cell adhesion}} {{GNF_GO|id=GO:0030334 |text = regulation of cell migration}} {{GNF_GO|id=GO:0045995 |text = regulation of embryonic development}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 3908
-    | Hs_Ensembl = ENSG00000196569
-    | Hs_RefseqProtein = NP_000417
-    | Hs_RefseqmRNA = NM_000426
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 6
-    | Hs_GenLoc_start = 129246035
-    | Hs_GenLoc_end = 129879407
-    | Hs_Uniprot = P24043
-    | Mm_EntrezGene = 16773
-    | Mm_Ensembl = ENSMUSG00000019899
-    | Mm_RefseqmRNA = NM_008481
-    | Mm_RefseqProtein = NP_032507
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 10
-    | Mm_GenLoc_start = 26670815
-    | Mm_GenLoc_end = 27306267
-    | Mm_Uniprot = Q8C9J2
-  }}
-}}
-'''Laminin, alpha 2 (merosin, congenital muscular dystrophy)''', also known as '''LAMA2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LAMA2 laminin, alpha 2 (merosin, congenital muscular dystrophy)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3908| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+[[Laminin]], an [[extracellular matrix]] protein, is a major component of the [[basement membrane]]. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of [[Congenital muscular dystrophy|congenital merosin-deficient muscular dystrophy]]. Two transcript variants encoding different proteins have been found for this gene.<ref name="entrez" />
-{{PBB_Summary
-| section_title =
-| summary_text = Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: LAMA2 laminin, alpha 2 (merosin, congenital muscular dystrophy)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3908| accessdate = }}</ref>
-}}
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
-{{PBB_Further_reading
+*{{cite journal  | author=Timpl R |title=Macromolecular organization of basement membranes |journal=Curr. Opin. Cell Biol. |volume=8 |issue= 5 |pages= 618–24 |year= 1997 |pmid= 8939648 |doi=10.1016/S0955-0674(96)80102-5  }}
-| citations =
+*{{cite journal  |vauthors=Belkin AM, Stepp MA |title=Integrins as receptors for laminins |journal=Microsc. Res. Tech. |volume=51 |issue= 3 |pages= 280–301 |year= 2000 |pmid= 11054877 |doi= 10.1002/1097-0029(20001101)51:3<280::AID-JEMT7>3.0.CO;2-O }}
-*{{cite journal  | author=Timpl R |title=Macromolecular organization of basement membranes. |journal=Curr. Opin. Cell Biol. |volume=8 |issue= 5 |pages= 618-24 |year= 1997 |pmid= 8939648 |doi=  }}
+*{{cite journal   |vauthors=Jones KJ, Morgan G, Johnston H, etal |title=The expanding phenotype of laminin α2 chain (merosin) abnormalities: case series and review |journal=J. Med. Genet. |volume=38 |issue= 10 |pages= 649–57 |year= 2002 |pmid= 11584042 |doi=10.1136/jmg.38.10.649  | pmc=1734735  }}
-*{{cite journal  | author=Belkin AM, Stepp MA |title=Integrins as receptors for laminins. |journal=Microsc. Res. Tech. |volume=51 |issue= 3 |pages= 280-301 |year= 2000 |pmid= 11054877 |doi= 10.1002/1097-0029(20001101)51:3<280::AID-JEMT7>3.0.CO;2-O }}
+*{{cite journal   |vauthors=Hori H, Kanamori T, Mizuta T, etal |title=Human laminin M chain: epitope analysis of its monoclonal antibodies by [[immunoscreening]] of cDNA clones and tissue expression |journal=J. Biochem. |volume=116 |issue= 6 |pages= 1212–9 |year= 1995 |pmid= 7535762 |doi=  }}
-*{{cite journal  | author=Jones KJ, Morgan G, Johnston H, ''et al.'' |title=The expanding phenotype of laminin alpha2 chain (merosin) abnormalities: case series and review. |journal=J. Med. Genet. |volume=38 |issue= 10 |pages= 649-57 |year= 2002 |pmid= 11584042 |doi=  }}
+*{{cite journal   |vauthors=Helbling-Leclerc A, Zhang X, Topaloglu H, etal |title=Mutations in the laminin alpha 2-chain gene (LAMA2) cause merosin-deficient congenital muscular dystrophy |journal=Nat. Genet. |volume=11 |issue= 2 |pages= 216–8 |year= 1995 |pmid= 7550355 |doi= 10.1038/ng1095-216 }}
-*{{cite journal  | author=Ehrig K, Leivo I, Argraves WS, ''et al.'' |title=Merosin, a tissue-specific basement membrane protein, is a laminin-like protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 9 |pages= 3264-8 |year= 1990 |pmid= 2185464 |doi=  }}
+*{{cite journal   |vauthors=Yamada H, Shimizu T, Tanaka T, etal |title=Dystroglycan is a binding protein of laminin and merosin in peripheral nerve |journal=FEBS Lett. |volume=352 |issue= 1 |pages= 49–53 |year= 1994 |pmid= 7925941 |doi=10.1016/0014-5793(94)00917-1  }}
-*{{cite journal  | author=Hori H, Kanamori T, Mizuta T, ''et al.'' |title=Human laminin M chain: epitope analysis of its monoclonal antibodies by immunoscreening of cDNA clones and tissue expression. |journal=J. Biochem. |volume=116 |issue= 6 |pages= 1212-9 |year= 1995 |pmid= 7535762 |doi=  }}
+*{{cite journal  |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791  }}
-*{{cite journal  | author=Helbling-Leclerc A, Zhang X, Topaloglu H, ''et al.'' |title=Mutations in the laminin alpha 2-chain gene (LAMA2) cause merosin-deficient congenital muscular dystrophy. |journal=Nat. Genet. |volume=11 |issue= 2 |pages= 216-8 |year= 1995 |pmid= 7550355 |doi= 10.1038/ng1095-216 }}
+*{{cite journal  |vauthors=Zhang X, Vuolteenaho R, Tryggvason K |title=Structure of the human laminin alpha2-chain gene (LAMA2), which is affected in congenital muscular dystrophy |journal=J. Biol. Chem. |volume=271 |issue= 44 |pages= 27664–9 |year= 1996 |pmid= 8910357 |doi=10.1074/jbc.271.44.27664  }}
-*{{cite journal  | author=Yamada H, Shimizu T, Tanaka T, ''et al.'' |title=Dystroglycan is a binding protein of laminin and merosin in peripheral nerve. |journal=FEBS Lett. |volume=352 |issue= 1 |pages= 49-53 |year= 1994 |pmid= 7925941 |doi=  }}
+*{{cite journal   |vauthors=Squarzoni S, Villanova M, Sabatelli P, etal |title=Intracellular detection of laminin alpha 2 chain in skin by electron microscopy immunocytochemistry: comparison between normal and laminin alpha 2 chain deficient subjects |journal=Neuromuscul. Disord. |volume=7 |issue= 2 |pages= 91–8 |year= 1997 |pmid= 9131649 |doi=10.1016/S0960-8966(96)00420-8  }}
-*{{cite journal  | author=Vuolteenaho R, Nissinen M, Sainio K, ''et al.'' |title=Human laminin M chain (merosin): complete primary structure, chromosomal assignment, and expression of the M and A chain in human fetal tissues. |journal=J. Cell Biol. |volume=124 |issue= 3 |pages= 381-94 |year= 1994 |pmid= 8294519 |doi=  }}
+*{{cite journal   |vauthors=Allamand V, Sunada Y, Salih MA, etal |title=Mild congenital muscular dystrophy in two patients with an internally deleted laminin alpha2-chain |journal=Hum. Mol. Genet. |volume=6 |issue= 5 |pages= 747–52 |year= 1997 |pmid= 9158149 |doi=10.1093/hmg/6.5.747  }}
-*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
+*{{cite journal   |vauthors=Durkin ME, Loechel F, Mattei MG, etal |title=Tissue-specific expression of the human laminin alpha5-chain, and mapping of the gene to human chromosome 20q13.2-13.3 and to distal mouse chromosome 2 near the locus for the ragged (Ra) mutation |journal=FEBS Lett. |volume=411 |issue= 2–3 |pages= 296–300 |year= 1997 |pmid= 9271224 |doi=10.1016/S0014-5793(97)00686-8  }}
-*{{cite journal  | author=Zhang X, Vuolteenaho R, Tryggvason K |title=Structure of the human laminin alpha2-chain gene (LAMA2), which is affected in congenital muscular dystrophy. |journal=J. Biol. Chem. |volume=271 |issue= 44 |pages= 27664-9 |year= 1996 |pmid= 8910357 |doi=  }}
+*{{cite journal  |vauthors=Mrowiec T, Melchar C, Górski A |title=HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium |journal=Arch. Immunol. Ther. Exp. (Warsz.) |volume=45 |issue= 2–3 |pages= 255–9 |year= 1998 |pmid= 9597096 |doi=  }}
-*{{cite journal  | author=Squarzoni S, Villanova M, Sabatelli P, ''et al.'' |title=Intracellular detection of laminin alpha 2 chain in skin by electron microscopy immunocytochemistry: comparison between normal and laminin alpha 2 chain deficient subjects. |journal=Neuromuscul. Disord. |volume=7 |issue= 2 |pages= 91-8 |year= 1997 |pmid= 9131649 |doi=  }}
+*{{cite journal   |vauthors=Koch M, Olson PF, Albus A, etal |title=Characterization and Expression of the Laminin γ3 Chain: A Novel, Non-Basement Membrane–associated, Laminin Chain |journal=J. Cell Biol. |volume=145 |issue= 3 |pages= 605–18 |year= 1999 |pmid= 10225960 |doi=10.1083/jcb.145.3.605  | pmc=2185082  }}
-*{{cite journal  | author=Allamand V, Sunada Y, Salih MA, ''et al.'' |title=Mild congenital muscular dystrophy in two patients with an internally deleted laminin alpha2-chain. |journal=Hum. Mol. Genet. |volume=6 |issue= 5 |pages= 747-52 |year= 1997 |pmid= 9158149 |doi=  }}
+*{{cite journal  |vauthors=Kuang W, Xu H, Vilquin JT, Engvall E |title=Activation of the lama2 gene in muscle regeneration: abortive regeneration in laminin alpha2-deficiency |journal=Lab. Invest. |volume=79 |issue= 12 |pages= 1601–13 |year= 2000 |pmid= 10616210 |doi=  }}
-*{{cite journal  | author=Durkin ME, Loechel F, Mattei MG, ''et al.'' |title=Tissue-specific expression of the human laminin alpha5-chain, and mapping of the gene to human chromosome 20q13.2-13.3 and to distal mouse chromosome 2 near the locus for the ragged (Ra) mutation. |journal=FEBS Lett. |volume=411 |issue= 2-3 |pages= 296-300 |year= 1997 |pmid= 9271224 |doi=  }}
+*{{cite journal   |vauthors=Pegoraro E, Fanin M, Trevisan CP, etal |title=A novel laminin alpha2 isoform in severe laminin alpha2 deficient congenital muscular dystrophy |journal=Neurology |volume=55 |issue= 8 |pages= 1128–34 |year= 2000 |pmid= 11071490 |doi=  10.1212/wnl.55.8.1128}}
-*{{cite journal  | author=Mrowiec T, Melchar C, Górski A |title=HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium. |journal=Arch. Immunol. Ther. Exp. (Warsz.) |volume=45 |issue= 2-3 |pages= 255-9 |year= 1998 |pmid= 9597096 |doi=  }}
+*{{cite journal  |vauthors=McArthur CP, Wang Y, Heruth D, Gustafson S |title=Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53 |journal=Arch. Oral Biol. |volume=46 |issue= 6 |pages= 545–55 |year= 2001 |pmid= 11311202 |doi=10.1016/S0003-9969(01)00014-0  }}
-*{{cite journal  | author=Koch M, Olson PF, Albus A, ''et al.'' |title=Characterization and expression of the laminin gamma3 chain: a novel, non-basement membrane-associated, laminin chain. |journal=J. Cell Biol. |volume=145 |issue= 3 |pages= 605-18 |year= 1999 |pmid= 10225960 |doi=  }}
-*{{cite journal  | author=Kuang W, Xu H, Vilquin JT, Engvall E |title=Activation of the lama2 gene in muscle regeneration: abortive regeneration in laminin alpha2-deficiency. |journal=Lab. Invest. |volume=79 |issue= 12 |pages= 1601-13 |year= 2000 |pmid= 10616210 |doi=  }}
-*{{cite journal  | author=Pegoraro E, Fanin M, Trevisan CP, ''et al.'' |title=A novel laminin alpha2 isoform in severe laminin alpha2 deficient congenital muscular dystrophy. |journal=Neurology |volume=55 |issue= 8 |pages= 1128-34 |year= 2000 |pmid= 11071490 |doi=  }}
-*{{cite journal  | author=McArthur CP, Wang Y, Heruth D, Gustafson S |title=Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53. |journal=Arch. Oral Biol. |volume=46 |issue= 6 |pages= 545-55 |year= 2001 |pmid= 11311202 |doi=  }}
-}}
 {{refend}}
-{{protein-stub}}
+==External links==
-{{WikiDoc Sources}}
+* [https://www.ncbi.nlm.nih.gov/books/NBK1291/  GeneReviews/NCBI/NIH/UW entry on Congenital Muscular Dystrophy Overview]
+* [[LOVD]] mutation database: [http://www.dmd.nl/nmdb2/?select_db=LAMA2 LAMA2]
+{{Fibrous proteins}}
+{{gene-6-stub}}
+[[Category:Laminins]]

Laminin, alpha 2: Difference between revisions

Latest revision as of 19:27, 2 September 2017

Contents

Function

References

Further reading

External links

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