LRDD

Leucine-rich repeats and death domain containing
File:PBB Protein LRDD image.jpg PDB rendering based on 2of5.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2of5​
Identifiers
Symbols	LRDD ; DKFZp434D229; MGC16925; PIDD
External IDs	Template:OMIM5 Template:MGI HomoloGene: 11220
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE LRDD 219019 at tn.png
File:PBB GE LRDD 221640 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Leucine-rich repeats and death domain containing, also known as LRDD, is a human gene.

The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.

Further reading

• Telliez JB, Bean KM, Lin LL (2000). "LRDD, a novel leucine rich repeat and death domain containing protein". Biochim. Biophys. Acta. 1478 (2): 280–8. PMID 10825539.CS1 maint: Multiple names: authors list (link)
• Lin Y, Ma W, Benchimol S (2000). "Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis". Nat. Genet. 26 (1): 122–7. doi:10.1038/79102. PMID 10973264.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tinel A, Tschopp J (2004). "The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress". Science. 304 (5672): 843–6. doi:10.1126/science.1095432. PMID 15073321.
• Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Janssens S, Tinel A, Lippens S, Tschopp J (2006). "PIDD mediates NF-kappaB activation in response to DNA damage". Cell. 123 (6): 1079–92. doi:10.1016/j.cell.2005.09.036. PMID 16360037.CS1 maint: Multiple names: authors list (link)
• Vakifahmetoglu H, Olsson M, Orrenius S, Zhivotovsky B (2006). "Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage". Oncogene. 25 (41): 5683–92. doi:10.1038/sj.onc.1209569. PMID 16652156.CS1 maint: Multiple names: authors list (link)
• Pick R, Badura S, Bösser S, Zörnig M (2006). "Upon intracellular processing, the C-terminal death domain-containing fragment of the p53-inducible PIDD/LRDD protein translocates to the nucleoli and interacts with nucleolin". Biochem. Biophys. Res. Commun. 349 (4): 1329–38. doi:10.1016/j.bbrc.2006.08.176. PMID 16982033.CS1 maint: Multiple names: authors list (link)
• Tinel A, Janssens S, Lippens S; et al. (2007). "Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway". EMBO J. 26 (1): 197–208. doi:10.1038/sj.emboj.7601473. PMID 17159900.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Park HH, Wu H (2007). "Crystallization and preliminary X-ray crystallographic studies of the oligomeric death-domain complex between PIDD and RAIDD". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63 (Pt 3): 229–32. doi:10.1107/S1744309107007889. PMID 17329820.
• Bradley G, Tremblay S, Irish J; et al. (2007). "The expression of p53-induced protein with death domain (Pidd) and apoptosis in oral squamous cell carcinoma". Br. J. Cancer. 96 (9): 1425–32. doi:10.1038/sj.bjc.6603745. PMID 17437012.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)