Kyotorphin
| Template:Chembox header| Kyotorphin | |
|---|---|
| Chemical structure of kyotorphin | |
| Systematic name | L-Arginine, L-tyrosyl- |
| Other names | kiotorphin |
| Chemical formula | C15H23N5O4 |
| Molecular mass | 337.374 g/mol |
| Density | x.xxx g/cm3 |
| Melting point | xx.x °C |
| Boiling point | xx.x °C |
| CAS number | 70904-56-2 |
| SMILES | C1=CC(=CC=C1CC(C(=O)NC(CCCN=C(N)N)C(=O)O)N)O |
| Template:Chembox header | Disclaimer and references | |
Kyotorphin (L-tyrosyl-L-arginine) is a neuroactive dipeptide which plays a role in pain regulation in the brain. It was first isolated from bovine brain by Japanese scientists in 1979[1]. Kyotorphin was named for the site of its discovery, Kyoto, Japan and because of its morphine- (or endorphin-) like analgesic activity. Kyotorphin has an analgesic effect, but it does not interact with the opioid receptors. Instead, it acts by releasing an Met-enkephalin and stabilizing it from degradation. It may also possess properties of neuromediator/neuromodulator. It has been shown that kyotorphin is present in the human cerebrospinal fluid and that it is lower in patients with persistent pain[2].
Notes
- ↑ Takagi H, Shiomi H, Ueda and Amano H (1979) A novel analgesic dipeptide from bovine brain is a possible met-enkephalin releaser. Nature (Lond) 282: 410-412.
- ↑ K, Kaya K, Hazato T, Ueda H, Satoh M, Takagi H. (1991) Kyotorphin like substance in human cerebrospinal fluid of patients with persistent pain Masui. Nov;40(11):1686-90.