Kyasanur forest disease: Difference between revisions
No edit summary |
|||
| Line 29: | Line 29: | ||
An affected person may recover in two weeks time, but the convalescent period is typically very long, lasting for several months. There will be muscle aches and weakness during this period and the affected person is unable to engage in physical activities. | An affected person may recover in two weeks time, but the convalescent period is typically very long, lasting for several months. There will be muscle aches and weakness during this period and the affected person is unable to engage in physical activities. | ||
==Prevention | ==Prevention== | ||
[[Prophylaxis]] by vaccination, as well as preventive measures like protective clothing, tick control, and mosquito control are advised. An [[attenuated]] [[live vaccine]] is now available. Specific treatments are not available. | [[Prophylaxis]] by vaccination, as well as preventive measures like protective clothing, tick control, and mosquito control are advised. An [[attenuated]] [[live vaccine]] is now available. Specific treatments are not available. | ||
{{ | ==References== | ||
{{reflist|2}} | |||
{{Viral diseases}} | {{Viral diseases}} | ||
[[Category:Viral diseases]] | [[Category:Viral diseases]] | ||
[[Category:Hemorrhagic fevers]] | [[Category:Hemorrhagic fevers]] | ||
[[Category:Needs content]] | |||
[[de:Kyasanur-Wald-Fieber]] | [[de:Kyasanur-Wald-Fieber]] | ||
[[fr:Fièvre de Kyasanur]] | [[fr:Fièvre de Kyasanur]] | ||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
Revision as of 18:35, 27 November 2012
Template:DiseaseDisorder infobox
Overview
Kyasanur forest disease is a tick-borne viral hemorrhagic fever endemic to South Asia. The disease is caused by a virus belonging to the family flaviviridae.
Historical Perspective
The disease was first reported from Kyasanur Forest of Karnataka in India in March 1957. The disease first manifested as an epizootic outbreak among monkeys killing several of them in the year 1957. Hence the disease is also locally known as Monkey Disease or Monkey Fever.[1] The similarity with Russian Spring-summer encephalitis was noted and the possibility of migratory birds carrying the disease was raised.[2] Studies began to look for the possible species that acted as reservoirs for the virus and the agents responsible for transmission. Subsequent studies failed to find any involvement of migratory birds although the possibility of their role in initial establishment was not ruled out. The virus was found to be quite distinctive and not closely related to the Russian virus strains. Antigenic relatedness is however close to many other strains including the Omsk hemorrhagic fever (OHF) and birds from Siberia have been found to show an antigenic response to KFD virus. Sequence based studies however note the distinctivenss of OHF.[3] Early studies in India were conducted in collaboration with the US Army Medical Research Unit and this led to controversy and conspiracy theories.[4][5]
Subsequent studies based on sequencing found that the Alkhurma virus, found in Saudi Arabia is closely related.[6] In 1989 a patient in Nanjianin, China was found with fever symptoms and in 2009 its viral gene sequence was found to exactly match with that of the KFD reference virus of 1957. This has however been questioned since the Indian virus shows variations in sequence over time and the exact match with the virus sequence of 1957 and the Chinese virus of 1989 is not expected. This study also found using immune response tests that birds and humans in the region appeared to have been exposed to the virus.[7] Another study has suggested that the virus is recent in origin dating the nearest common ancestor of it and related viruses to around 1942, based on the estimated rate of sequence substitutions. The study also raises the possibility of bird involvement in long-distance transfer.[8] It appears that these viruses diverged 700 years ago.[9]
Transmission
The reservoir hosts for the disease are porcupines, rats and mice. The vector for disease transmission is Haemaphysalis spinigera, a forest tick. Humans contract infection from the bite of nymphs of the tick.
Presentation
The disease has a high morbidity rate of 10 %.
The clinical manifestations of the disease in humans are:
- High fever
- Headache
- Haemorrhages from nasal cavity and throat
- Vomiting
An affected person may recover in two weeks time, but the convalescent period is typically very long, lasting for several months. There will be muscle aches and weakness during this period and the affected person is unable to engage in physical activities.
Prevention
Prophylaxis by vaccination, as well as preventive measures like protective clothing, tick control, and mosquito control are advised. An attenuated live vaccine is now available. Specific treatments are not available.
References
- ↑ Nichter, Mark (1987). "Kyasanur Forest Disease: An Ethnography of a Disease of Development". Medical Anthropology Quarterly, New Series. 1 (4): 406–423.
- ↑ Work, Telford H.; Roderiguez, FR; Bhatt, PN (1959). "Virological Epidemiology of the 1958 Epidemic of Kyasanur Forest Disease". American Journal of Public Health. 49 (7): 869–874. doi:10.2105/AJPH.49.7.869. PMC 1372906. PMID 13661478.
- ↑ Lin D, Li L, Dick D, Shope RE, Feldmann H, Barrett AD, Holbrook MR (2003). "Analysis of the complete genome of the tick-borne flavivirus Omsk hemorrhagic fever virus". Virology. 313 (1): 81–90. doi:10.1016/S0042-6822(03)00246-0. PMID 12951023.
- ↑ Harry Hoogstraal, Makram N. Kaiser, Melvin A. Traylor, Ezzat Guindy, and Sobhy Gaber (1963). "Ticks (Ixodidae) on birds migrating from Europe and Asia to Africa, 1959-61". Bulletin World Health Organ. 28 (2): 235–262. PMC 2554471. PMID 13961632.
- ↑ Lewis, Michael (2002). "Scientists or Spies? Ecology in a Climate of Cold War Suspicion". Economic and Political Weekly. 37 (24): 2324–2332.
- ↑ Charrel RN, Zaki AM, Attoui H, Fakeeh M, Billoir F, Yousef AI, de Chesse R, De Micco P, Gould EA, de Lamballerie X. (2001). "Complete coding sequence of the Alkhurma virus, a tick-borne flavivirus causing severe hemorrhagic fever in humans in Saudi Arabia". Biochem. Biophys Res. Commun. 287 (2): 455–61. doi:10.1006/bbrc.2001.5610. PMID 11554750.
- ↑ Jinglin Wang, Hailin Zhang, Shihong Fu, Huanyu Wang, Daxin Ni, Roger Nasci, Qing Tang, and Guodong Liang (2009). "Isolation of Kyasanur Forest Disease Virus from Febrile Patient, Yunnan, China". Emerg. Infect. Dis. 15 (2): 326–328. doi:10.3201/eid1502.080979. PMC 2657630. PMID 19193286.
- ↑ Rajeev Mehla, Sandeep R.P. Kumar, Pragya Yadav, Pradip V. Barde, Prasanna N. Yergolkar, Bobbie R. Erickson, Serena A. Carroll, Akhilesh C. Mishra, Stuart T. Nichol, and Devendra T. Mourya (2009). "Recent Ancestry of Kyasanur Forest Disease Virus". Emerging Infectious Diseases. 15 (9): 1431–1437. doi:10.3201/eid1509.080759. PMC 2819879. PMID 19788811.
- ↑ Dodd KA, Bird BH, Khristova ML, Albariño CG, Carroll SA, Comer JA, Erickson BR, Rollin PE, Nichol ST (2011) Ancient ancestry of KFDV and AHFV revealed by complete genome analyses of viruses isolated from ticks and mammalian hosts. PLoS Negl Trop Dis 5(10):e1352.