Ketamine

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Ketamine
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chetan Lokhande, M.B.B.S [2]

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Overview

Ketamine is a general anesthetic that is FDA approved for the {{{indicationType}}} of general anesthesia; adjunct, procedural sedation. Common adverse reactions include cardiovascular: hypertension, tachycardia, neurologic: emergence from anesthesia, psychiatric sign or symptom (12% to 50% )..

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

  • General anesthesia; adjunct: induction, 1 to 4.5 mg (base)/kg IV single dose
  • General anesthesia; adjunct: induction, 1 to 2 mg/kg IV infusion at 0.5 mg/kg/min; in addition to diazepam 2 to 5 mg IV over 1 min
  • General anesthesia; adjunct: induction, 6.5 to 13 mg (base)/kg IM
  • General anesthesia; adjunct: maintenance, 0.1 to 0.5 mg (base)/min IV infusion, repeat as needed; augmented with diazepam 2 to 5 mg IV
  • General anesthesia; adjunct: maintenance, 0.01 to 0.03 mg/kg/min continuous IV infusion
  • General anesthesia; adjunct: maintenance, increments of one-half to the full induction dose may be repeated as needed
  • Procedural sedation: 1 to 2 mg/kg IV over 1 to 2 min, may be followed by 0.25 to 0.5 mg/kg IV every 5 to 10 min as needed.
  • Rapid sequence intubation, Induction: 2 mg/kg IV.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

  • General anesthesia; Adjunct.
  • Procedural sedation.

Non–Guideline-Supported Use

  • Administration of analgesic - sedation.
  • Bronchospasm.
  • Rapid sequence intubation, induction

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

  • Safety and efficacy have not been established in children younger than 16 years.
  • General anesthesia; adjunct: induction, 5 to 10 mg (base)/kg IM; range, 4 to 13 mg/kg.
  • General anesthesia; adjunct: induction, 1 to 2 mg/kg IV; range, 0.5 to 4.5 mg/kg.
  • General anesthesia; adjunct: maintenance, 0.01 to 0.03 mg/kg/min continuous IV infusion.
  • General anesthesia; adjunct: maintenance, increments of one-half to the full induction dose may be repeated as needed.
  • Procedural sedation: 0.5 to 2 mg/kg IV over 1 to 2 min, may repeat 0.25 to 1 mg/kg IV (one-half initial dose) every 10 to 15 min as needed.
  • Procedural sedation: 2 to 5 mg/kg IM, may repeat 2 to 4 mg/kg after 10 min.
  • Rapid sequence intubation, Induction: 1 to 3 mg/kg IV.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information about Off-Label Guideline-Supported Use of Ketamine in pediatric patients.

Non–Guideline-Supported Use

There is limited information about Off-Label Non–Guideline-Supported Use of Ketamine in pediatric patients.

Contraindications

There is limited information regarding Ketamine Contraindications in the drug label.

Warnings

There is limited information regarding Ketamine Warnings' in the drug label.

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Ketamine Clinical Trials Experience in the drug label.

Postmarketing Experience

There is limited information regarding Ketamine Postmarketing Experience in the drug label.

Drug Interactions

There is limited information regarding Ketamine Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): There is no FDA guidance on usage of Ketamine in women who are pregnant.
Pregnancy Category (AUS): There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Ketamine in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Ketamine during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Ketamine in women who are nursing.

Pediatric Use

There is no FDA guidance on the use of Ketamine in pediatric settings.

Geriatic Use

There is no FDA guidance on the use of Ketamine in geriatric settings.

Gender

There is no FDA guidance on the use of Ketamine with respect to specific gender populations.

Race

There is no FDA guidance on the use of Ketamine with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Ketamine in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Ketamine in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Ketamine in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Ketamine in patients who are immunocompromised.

Administration and Monitoring

Administration

There is limited information regarding Ketamine Administration in the drug label.

Monitoring

There is limited information regarding Ketamine Monitoring in the drug label.

IV Compatibility

There is limited information regarding the compatibility of Ketamine and IV administrations.

Overdosage

There is limited information regarding Ketamine overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.

Pharmacology

There is limited information regarding Ketamine Pharmacology in the drug label.

Mechanism of Action

There is limited information regarding Ketamine Mechanism of Action in the drug label.

Structure

There is limited information regarding Ketamine Structure in the drug label.

Pharmacodynamics

There is limited information regarding Ketamine Pharmacodynamics in the drug label.

Pharmacokinetics

There is limited information regarding Ketamine Pharmacokinetics in the drug label.

Nonclinical Toxicology

There is limited information regarding Ketamine Nonclinical Toxicology in the drug label.

Clinical Studies

There is limited information regarding Ketamine Clinical Studies in the drug label.

How Supplied

There is limited information regarding Ketamine How Supplied in the drug label.

Storage

There is limited information regarding Ketamine Storage in the drug label.

Images

Drug Images

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Package and Label Display Panel

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Patient Counseling Information

There is limited information regarding Ketamine Patient Counseling Information in the drug label.

Precautions with Alcohol

Alcohol-Ketamine interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

There is limited information regarding Ketamine Brand Names in the drug label.

Look-Alike Drug Names

There is limited information regarding Ketamine Look-Alike Drug Names in the drug label.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.