Keratin 18: Difference between revisions

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'''Keratin 18''' is a [[type I cytokeratin]]. It is, together with its filament partner [[keratin 8]], perhaps the most commonly found products of the [[intermediate filament]] gene family. They are expressed in single layer [[epithelial tissue]]s of the body. Mutations in this gene have been linked to [[cryptogenic cirrhosis]]. Two transcript variants encoding the same protein have been found for this gene.<ref>{{cite web | title = Entrez Gene: KRT18 keratin 18| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3875| accessdate = }}</ref>
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Keratin 18 is often used together with [[keratin 8]] and [[keratin 19]] to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate [[circulating tumor cell]]s in blood.<ref>{{cite journal |author1=W. Jeffrey Allard |author2=Jeri Matera |author3=M. Craig Miller |title=Tumor Cells Circulate in the Peripheral Blood of All Major Carcinomas but not in Healthy Subjects or Patients With Nonmalignant Diseases |journal=Clin. Cancer Research |volume=10 |pages=6897–6904 |date=October 2004 |doi=10.1158/1078-0432.CCR-04-0378 |pmid=15501967 |issue=20|display-authors=etal}}</ref>
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==Interactions==
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Keratin 18 has been shown to [[Protein-protein interaction|interact]] with [[Collagen, type XVII, alpha 1]],<ref name=pmid10022517>{{cite journal |last=Aho |first=S |authorlink= |author2=Uitto J |date=March 1999 |title=180-kD bullous pemphigoid antigen/type XVII collagen: tissue-specific expression and molecular interactions with keratin 18 |journal=J. Cell. Biochem. |volume=72 |issue=3 |pages=356–67 |publisher= |location = UNITED STATES| issn = 0730-2312| pmid = 10022517 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1002/(SICI)1097-4644(19990301)72:3<356::AID-JCB5>3.0.CO;2-M }}</ref> [[DNAJB6]],<ref name=pmid10954706>{{cite journal |last=Izawa |first=I |authorlink= |author2=Nishizawa M |author3=Ohtakara K |author4=Ohtsuka K |author5=Inada H |author6=Inagaki M |date=November 2000  |title=Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin 8/18 filament regulatory protein |journal=J. Biol. Chem. |volume=275 |issue=44 |pages=34521–7 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10954706 |doi = 10.1074/jbc.M003492200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Pinin]]<ref name=pmid10809736>{{cite journal |last=Shi |first=J |authorlink= |author2=Sugrue S P  |date=May 2000 |title=Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus |journal=J. Biol. Chem. |volume=275 |issue=20 |pages=14910–5 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10809736 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.275.20.14910 }}</ref> and [[TRADD]].<ref name=pmid11684708>{{cite journal |last=Inada |first=H |authorlink= |author2=Izawa I |author3=Nishizawa M |author4=Fujita E |author5=Kiyono T |author6=Takahashi T |author7=Momoi T |author8=Inagaki M  |date=October 2001  |title=Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD |journal=J. Cell Biol. |volume=155 |issue=3 |pages=415–26 |publisher= |location = United States| issn = 0021-9525| pmid = 11684708 |doi = 10.1083/jcb.200103078 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=2150850 }}</ref>
{{GNF_Protein_box
| image =
| image_source =
  | PDB =  
  | Name = Keratin 18
| HGNCid = 6430
| Symbol = KRT18
| AltSymbols =; CYK18; K18
| OMIM = 148070
| ECnumber =
| Homologene = 55448
| MGIid = 96692
| GeneAtlas_image1 = PBB_GE_KRT18_201596_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005200 |text = structural constituent of cytoskeleton}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005882 |text = intermediate filament}}
  | Process = {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3875
    | Hs_Ensembl = ENSG00000111057
    | Hs_RefseqProtein = NP_000215
    | Hs_RefseqmRNA = NM_000224
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 51629225
    | Hs_GenLoc_end = 51632951
    | Hs_Uniprot = P05783
    | Mm_EntrezGene = 16668
    | Mm_Ensembl = ENSMUSG00000023043
    | Mm_RefseqmRNA = NM_010664
    | Mm_RefseqProtein = NP_034794
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 101856259
    | Mm_GenLoc_end = 101860055
    | Mm_Uniprot = Q3TIX1
  }}
}}
'''Keratin 18''' is a [[type I cytokeratin]]. It is, together with its filament partner [[keratin 8]], perhaps the most commonly found products of the [[intermediate filament]] gene family. They are expressed in single layer [[epithelial tissue]]s of the body. Mutations in this gene have been linked to [[cryptogenic cirrhosis]]. Two transcript variants encoding the same protein have been found for this gene.<ref>{{cite web | title = Entrez Gene: KRT18 keratin 18| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3875| accessdate = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
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| citations =  
| citations =  
*{{cite journal | author=Omary MB, Baxter GT, Chou CF, ''et al.'' |title=PKC epsilon-related kinase associates with and phosphorylates cytokeratin 8 and 18. |journal=J. Cell Biol. |volume=117 |issue= 3 |pages= 583-93 |year= 1992 |pmid= 1374067 |doi=  10.1083/jcb.117.3.583}}
*{{cite journal   |vauthors=Omary MB, Baxter GT, Chou CF, etal |title=PKC epsilon-related kinase associates with and phosphorylates cytokeratin 8 and 18 |journal=J. Cell Biol. |volume=117 |issue= 3 |pages= 583–93 |year= 1992 |pmid= 1374067 |doi=  10.1083/jcb.117.3.583 | pmc=2289443}}
*{{cite journal  | author=Waseem A, Gough AC, Spurr NK, Lane EB |title=Localization of the gene for human simple epithelial keratin 18 to chromosome 12 using polymerase chain reaction. |journal=Genomics |volume=7 |issue= 2 |pages= 188-94 |year= 1990 |pmid= 1693358 |doi=  10.1016/0888-7543(90)90540-B}}
*{{cite journal  |vauthors=Waseem A, Gough AC, Spurr NK, Lane EB |title=Localization of the gene for human simple epithelial keratin 18 to chromosome 12 using polymerase chain reaction |journal=Genomics |volume=7 |issue= 2 |pages= 188–94 |year= 1990 |pmid= 1693358 |doi=  10.1016/0888-7543(90)90540-B}}
*{{cite journal | author=Heath P, Elvin P, Jenner D, ''et al.'' |title=Localisation of a cDNA clone for human cytokeratin 18 to chromosome 17p11-p12 by in situ hybridisation. |journal=Hum. Genet. |volume=85 |issue= 6 |pages= 669-70 |year= 1990 |pmid= 1699878 |doi=  10.1007/BF00193596}}
*{{cite journal   |vauthors=Heath P, Elvin P, Jenner D, etal |title=Localisation of a cDNA clone for human cytokeratin 18 to chromosome 17p11-p12 by in situ hybridisation |journal=Hum. Genet. |volume=85 |issue= 6 |pages= 669–70 |year= 1990 |pmid= 1699878 |doi=  10.1007/BF00193596}}
*{{cite journal  | author=Waseem A, Alexander CM, Steel JB, Lane EB |title=Embryonic simple epithelial keratins 8 and 18: chromosomal location emphasizes difference from other keratin pairs. |journal=New Biol. |volume=2 |issue= 5 |pages= 464-78 |year= 1991 |pmid= 1705144 |doi=  }}
*{{cite journal  |vauthors=Waseem A, Alexander CM, Steel JB, Lane EB |title=Embryonic simple epithelial keratins 8 and 18: chromosomal location emphasizes difference from other keratin pairs |journal=New Biol. |volume=2 |issue= 5 |pages= 464–78 |year= 1991 |pmid= 1705144 |doi=  }}
*{{cite journal | author=Romano V, Hatzfeld M, Magin TM, ''et al.'' |title=Cytokeratin expression in simple epithelia. I. Identification of mRNA coding for human cytokeratin no. 18 by a cDNA clone. |journal=Differentiation |volume=30 |issue= 3 |pages= 244-53 |year= 1986 |pmid= 2422083 |doi=  }}
*{{cite journal   |vauthors=Romano V, Hatzfeld M, Magin TM, etal |title=Cytokeratin expression in simple epithelia. I. Identification of mRNA coding for human cytokeratin no. 18 by a cDNA clone |journal=Differentiation |volume=30 |issue= 3 |pages= 244–53 |year= 1986 |pmid= 2422083 |doi=  10.1111/j.1432-0436.1986.tb00787.x}}
*{{cite journal  | author=Oshima RG, Millán JL, Ceceña G |title=Comparison of mouse and human keratin 18: a component of intermediate filaments expressed prior to implantation. |journal=Differentiation |volume=33 |issue= 1 |pages= 61-8 |year= 1987 |pmid= 2434380 |doi=  10.1111/j.1432-0436.1987.tb01542.x}}
*{{cite journal  |vauthors=Oshima RG, Millán JL, Ceceña G |title=Comparison of mouse and human keratin 18: a component of intermediate filaments expressed prior to implantation |journal=Differentiation |volume=33 |issue= 1 |pages= 61–8 |year= 1987 |pmid= 2434380 |doi=  10.1111/j.1432-0436.1987.tb01542.x}}
*{{cite journal | author=Leube RE, Bosch FX, Romano V, ''et al.'' |title=Cytokeratin expression in simple epithelia. III. Detection of mRNAs encoding human cytokeratins nos. 8 and 18 in normal and tumor cells by hybridization with cDNA sequences in vitro and in situ. |journal=Differentiation |volume=33 |issue= 1 |pages= 69-85 |year= 1987 |pmid= 2434381 |doi=  }}
*{{cite journal   |vauthors=Leube RE, Bosch FX, Romano V, etal |title=Cytokeratin expression in simple epithelia. III. Detection of mRNAs encoding human cytokeratins nos. 8 and 18 in normal and tumor cells by hybridization with cDNA sequences in vitro and in situ |journal=Differentiation |volume=33 |issue= 1 |pages= 69–85 |year= 1987 |pmid= 2434381 |doi=  10.1111/j.1432-0436.1986.tb00412.x}}
*{{cite journal  | author=Kulesh DA, Oshima RG |title=Cloning of the human keratin 18 gene and its expression in nonepithelial mouse cells. |journal=Mol. Cell. Biol. |volume=8 |issue= 4 |pages= 1540-50 |year= 1988 |pmid= 2454392 |doi=  }}
*{{cite journal  |vauthors=Kulesh DA, Oshima RG |title=Cloning of the human keratin 18 gene and its expression in nonepithelial mouse cells |journal=Mol. Cell. Biol. |volume=8 |issue= 4 |pages= 1540–50 |year= 1988 |pmid= 2454392 |doi=  | pmc=363314  }}
*{{cite journal | author=Sémat A, Vasseur M, Maillet L, ''et al.'' |title=Sequence analysis of murine cytokeratin endo A (no. 8) cDNA. Evidence for mRNA species initiated upstream of the normal 5' end in PCC4 cells. |journal=Differentiation |volume=37 |issue= 1 |pages= 40-6 |year= 1988 |pmid= 2454862 |doi=  10.1111/j.1432-0436.1988.tb00794.x}}
*{{cite journal   |vauthors=Sémat A, Vasseur M, Maillet L, etal |title=Sequence analysis of murine cytokeratin endo A (no. 8) cDNA. Evidence for mRNA species initiated upstream of the normal 5' end in PCC4 cells |journal=Differentiation |volume=37 |issue= 1 |pages= 40–6 |year= 1988 |pmid= 2454862 |doi=  10.1111/j.1432-0436.1988.tb00794.x}}
*{{cite journal  | author=Kulesh DA, Oshima RG |title=Complete structure of the gene for human keratin 18. |journal=Genomics |volume=4 |issue= 3 |pages= 339-47 |year= 1989 |pmid= 2469635 |doi=  10.1016/0888-7543(89)90340-6}}
*{{cite journal  |vauthors=Kulesh DA, Oshima RG |title=Complete structure of the gene for human keratin 18 |journal=Genomics |volume=4 |issue= 3 |pages= 339–47 |year= 1989 |pmid= 2469635 |doi=  10.1016/0888-7543(89)90340-6}}
*{{cite journal  | author=Ku NO, Omary MB |title=Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization. |journal=J. Cell Biol. |volume=127 |issue= 1 |pages= 161-71 |year= 1994 |pmid= 7523419 |doi=  10.1083/jcb.127.1.161}}
*{{cite journal  |vauthors=Ku NO, Omary MB |title=Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization |journal=J. Cell Biol. |volume=127 |issue= 1 |pages= 161–71 |year= 1994 |pmid= 7523419 |doi=  10.1083/jcb.127.1.161 | pmc=2120194}}
*{{cite journal  | author=Liao J, Lowthert LA, Ghori N, Omary MB |title=The 70-kDa heat shock proteins associate with glandular intermediate filaments in an ATP-dependent manner. |journal=J. Biol. Chem. |volume=270 |issue= 2 |pages= 915-22 |year= 1995 |pmid= 7529764 |doi= }}
*{{cite journal  |vauthors=Liao J, Lowthert LA, Ghori N, Omary MB |title=The 70-kDa heat shock proteins associate with glandular intermediate filaments in an ATP-dependent manner |journal=J. Biol. Chem. |volume=270 |issue= 2 |pages= 915–22 |year= 1995 |pmid= 7529764 |doi=10.1074/jbc.270.2.915  }}
*{{cite journal | author=Yoon SJ, LeBlanc-Straceski J, Ward D, ''et al.'' |title=Organization of the human keratin type II gene cluster at 12q13. |journal=Genomics |volume=24 |issue= 3 |pages= 502-8 |year= 1995 |pmid= 7536183 |doi= 10.1006/geno.1994.1659 }}
*{{cite journal   |vauthors=Yoon SJ, LeBlanc-Straceski J, Ward D, etal |title=Organization of the human keratin type II gene cluster at 12q13 |journal=Genomics |volume=24 |issue= 3 |pages= 502–8 |year= 1995 |pmid= 7536183 |doi= 10.1006/geno.1994.1659 }}
*{{cite journal  | author=Ku NO, Omary MB |title=Identification and mutational analysis of the glycosylation sites of human keratin 18. |journal=J. Biol. Chem. |volume=270 |issue= 20 |pages= 11820-7 |year= 1995 |pmid= 7538124 |doi= }}
*{{cite journal  |vauthors=Ku NO, Omary MB |title=Identification and mutational analysis of the glycosylation sites of human keratin 18 |journal=J. Biol. Chem. |volume=270 |issue= 20 |pages= 11820–7 |year= 1995 |pmid= 7538124 |doi=10.1074/jbc.270.20.11820  }}
*{{cite journal  | author=Neumaier M, Gerhard M, Wagener C |title=Diagnosis of micrometastases by the amplification of tissue-specific genes. |journal=Gene |volume=159 |issue= 1 |pages= 43-7 |year= 1995 |pmid= 7541767 |doi=  10.1016/0378-1119(94)00522-T}}
*{{cite journal  |vauthors=Neumaier M, Gerhard M, Wagener C |title=Diagnosis of micrometastases by the amplification of tissue-specific genes |journal=Gene |volume=159 |issue= 1 |pages= 43–7 |year= 1995 |pmid= 7541767 |doi=  10.1016/0378-1119(94)00522-T}}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal | author=Liao J, Lowthert LA, Ku NO, ''et al.'' |title=Dynamics of human keratin 18 phosphorylation: polarized distribution of phosphorylated keratins in simple epithelial tissues. |journal=J. Cell Biol. |volume=131 |issue= 5 |pages= 1291-301 |year= 1996 |pmid= 8522590 |doi= }}
*{{cite journal   |vauthors=Liao J, Lowthert LA, Ku NO, etal |title=Dynamics of human keratin 18 phosphorylation: polarized distribution of phosphorylated keratins in simple epithelial tissues |journal=J. Cell Biol. |volume=131 |issue= 5 |pages= 1291–301 |year= 1996 |pmid= 8522590 |doi=10.1083/jcb.131.5.1291  | pmc=2120635  }}
*{{cite journal | author=Ku NO, Wright TL, Terrault NA, ''et al.'' |title=Mutation of human keratin 18 in association with cryptogenic cirrhosis. |journal=J. Clin. Invest. |volume=99 |issue= 1 |pages= 19-23 |year= 1997 |pmid= 9011570 |doi=  10.1172/JCI119127}}
*{{cite journal   |vauthors=Ku NO, Wright TL, Terrault NA, etal |title=Mutation of human keratin 18 in association with cryptogenic cirrhosis |journal=J. Clin. Invest. |volume=99 |issue= 1 |pages= 19–23 |year= 1997 |pmid= 9011570 |doi=  10.1172/JCI119127 | pmc=507762}}
*{{cite journal | author=Ji H, Reid GE, Moritz RL, ''et al.'' |title=A two-dimensional gel database of human colon carcinoma proteins. |journal=Electrophoresis |volume=18 |issue= 3-4 |pages= 605-13 |year= 1997 |pmid= 9150948 |doi= 10.1002/elps.1150180344 }}
*{{cite journal   |vauthors=Ji H, Reid GE, Moritz RL, etal |title=A two-dimensional gel database of human colon carcinoma proteins |journal=Electrophoresis |volume=18 |issue= 3–4 |pages= 605–13 |year= 1997 |pmid= 9150948 |doi= 10.1002/elps.1150180344 }}
}}
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{{Cytoskeletal proteins}}
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[[Category:Keratins]]
[[Category:Keratins]]


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{{Fibrous proteins}}
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Latest revision as of 00:50, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Keratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.[1]

Keratin 18 is often used together with keratin 8 and keratin 19 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood.[2]

Interactions

Keratin 18 has been shown to interact with Collagen, type XVII, alpha 1,[3] DNAJB6,[4] Pinin[5] and TRADD.[6]

References

  1. ↑ "Entrez Gene: KRT18 keratin 18".
  2. ↑ W. Jeffrey Allard; Jeri Matera; M. Craig Miller; et al. (October 2004). "Tumor Cells Circulate in the Peripheral Blood of All Major Carcinomas but not in Healthy Subjects or Patients With Nonmalignant Diseases". Clin. Cancer Research. 10 (20): 6897–6904. doi:10.1158/1078-0432.CCR-04-0378. PMID 15501967.
  3. ↑ Aho, S; Uitto J (March 1999). "180-kD bullous pemphigoid antigen/type XVII collagen: tissue-specific expression and molecular interactions with keratin 18". J. Cell. Biochem. UNITED STATES. 72 (3): 356–67. doi:10.1002/(SICI)1097-4644(19990301)72:3<356::AID-JCB5>3.0.CO;2-M. ISSN 0730-2312. PMID 10022517.
  4. ↑ Izawa, I; Nishizawa M; Ohtakara K; Ohtsuka K; Inada H; Inagaki M (November 2000). "Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin 8/18 filament regulatory protein". J. Biol. Chem. UNITED STATES. 275 (44): 34521–7. doi:10.1074/jbc.M003492200. ISSN 0021-9258. PMID 10954706.
  5. ↑ Shi, J; Sugrue S P (May 2000). "Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus". J. Biol. Chem. UNITED STATES. 275 (20): 14910–5. doi:10.1074/jbc.275.20.14910. ISSN 0021-9258. PMID 10809736.
  6. ↑ Inada, H; Izawa I; Nishizawa M; Fujita E; Kiyono T; Takahashi T; Momoi T; Inagaki M (October 2001). "Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD". J. Cell Biol. United States. 155 (3): 415–26. doi:10.1083/jcb.200103078. ISSN 0021-9525. PMC 2150850. PMID 11684708.

Further reading


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