KIN (gene)

KIN, antigenic determinant of recA protein homolog (mouse)
File:PBB Protein KIN image.jpg PDB rendering based on 2ckk.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2ckk​
Identifiers
Symbols	KIN ; BTCD; KIN17
External IDs	Template:OMIM5 Template:MGI HomoloGene: 8196
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE KIN 205664 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

KIN, antigenic determinant of recA protein homolog (mouse), also known as KIN, is a human gene.

The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog.

Further reading

• Angulo JF, Rouer E, Mazin A; et al. (1991). "Identification and expression of the cDNA of KIN17, a zinc-finger gene located on mouse chromosome 2, encoding a new DNA-binding protein". Nucleic Acids Res. 19 (19): 5117–23. PMID 1923796.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Biard DS, Saintigny Y, Maratrat M; et al. (1997). "Differential expression of the HsKin17 protein during differentiation of in vitro reconstructed human skin". Arch. Dermatol. Res. 289 (8): 448–56. PMID 9266022.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kannouche P, Angulo JF (1999). "Overexpression of kin17 protein disrupts nuclear morphology and inhibits the growth of mammalian cells". J. Cell. Sci. 112 ( Pt 19): 3215–24. PMID 10504327.
• Blattner C, Kannouche P, Litfin M; et al. (2000). "UV-Induced stabilization of c-fos and other short-lived mRNAs". Mol. Cell. Biol. 20 (10): 3616–25. PMID 10779351.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kannouche P, Mauffrey P, Pinon-Lataillade G; et al. (2000). "Molecular cloning and characterization of the human KIN17 cDNA encoding a component of the UVC response that is conserved among metazoans". Carcinogenesis. 21 (9): 1701–10. PMID 10964102.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Biard DS, Miccoli L, Despras E; et al. (2002). "Ionizing radiation triggers chromatin-bound kin17 complex formation in human cells". J. Biol. Chem. 277 (21): 19156–65. doi:10.1074/jbc.M200321200. PMID 11880372.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miccoli L, Biard DS, Créminon C, Angulo JF (2002). "Human kin17 protein directly interacts with the simian virus 40 large T antigen and inhibits DNA replication". Cancer Res. 62 (19): 5425–35. PMID 12359749.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Masson C, Menaa F, Pinon-Lataillade G; et al. (2003). "Global genome repair is required to activate KIN17, a UVC-responsive gene involved in DNA replication". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 616–21. doi:10.1073/pnas.0236176100. PMID 12525703.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Despras E, Miccoli L, Créminon C; et al. (2003). "Depletion of KIN17, a human DNA replication protein, increases the radiosensitivity of RKO cells". Radiat. Res. 159 (6): 748–58. PMID 12751957.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Biard DS, Miccoli L, Despras E; et al. (2004). "Participation of kin17 protein in replication factories and in other DNA transactions mediated by high molecular weight nuclear complexes". Mol. Cancer Res. 1 (7): 519–31. PMID 12754299.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miccoli L, Biard DS, Frouin I; et al. (2003). "Selective interactions of human kin17 and RPA proteins with chromatin and the nuclear matrix in a DNA damage- and cell cycle-regulated manner". Nucleic Acids Res. 31 (14): 4162–75. PMID 12853634.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Andersen JS, Lam YW, Leung AK; et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miccoli L, Frouin I, Novac O; et al. (2005). "The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins". Mol. Cell. Biol. 25 (9): 3814–30. doi:10.1128/MCB.25.9.3814-3830.2005. PMID 15831485.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• le Maire A, Schiltz M, Braud S; et al. (2006). "Crystallization and halide phasing of the C-terminal domain of human KIN17". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 62 (Pt 3): 245–8. doi:10.1107/S174430910600409X. PMID 16511313.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• le Maire A, Schiltz M, Stura EA; et al. (2007). "A tandem of SH3-like domains participates in RNA binding in KIN17, a human protein activated in response to genotoxics". J. Mol. Biol. 364 (4): 764–76. doi:10.1016/j.jmb.2006.09.033. PMID 17045609.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)