KIF23
| Kinesin family member 23 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | KIF23 ; CHO1; KNSL5; MKLP-1; MKLP1 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 11491 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE KIF23 204709 s at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Kinesin family member 23, also known as KIF23, is a human gene.[1]
The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in two transcript variants encoding two different isoforms.[1]
References
Further reading
- Miki H, Setou M, Kaneshiro K, Hirokawa N (2001). "All kinesin superfamily protein, KIF, genes in mouse and human". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7004–11. doi:10.1073/pnas.111145398. PMID 11416179.
- Nislow C, Lombillo VA, Kuriyama R, McIntosh JR (1992). "A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles". Nature. 359 (6395): 543–7. doi:10.1038/359543a0. PMID 1406973.
- Lee KS, Yuan YL, Kuriyama R, Erikson RL (1996). "Plk is an M-phase-specific protein kinase and interacts with a kinesin-like protein, CHO1/MKLP-1". Mol. Cell. Biol. 15 (12): 7143–51. PMID 8524282.
- Deavours BE, Walker RA (1999). "Nuclear localization of C-terminal domains of the kinesin-like protein MKLP-1". Biochem. Biophys. Res. Commun. 260 (3): 605–8. doi:10.1006/bbrc.1999.0952. PMID 10403813.
- Boman AL, Kuai J, Zhu X; et al. (1999). "Arf proteins bind to mitotic kinesin-like protein 1 (MKLP1) in a GTP-dependent fashion". Cell Motil. Cytoskeleton. 44 (2): 119–32. doi:10.1002/(SICI)1097-0169(199910)44:2<119::AID-CM4>3.0.CO;2-C. PMID 10506747.
- Mishima M, Kaitna S, Glotzer M (2002). "Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity". Dev. Cell. 2 (1): 41–54. PMID 11782313.
- Kuriyama R, Gustus C, Terada Y; et al. (2002). "CHO1, a mammalian kinesin-like protein, interacts with F-actin and is involved in the terminal phase of cytokinesis". J. Cell Biol. 156 (5): 783–90. doi:10.1083/jcb.200109090. PMID 11877456.
- Kitamura T, Kawashima T, Minoshima Y; et al. (2002). "Role of MgcRacGAP/Cyk4 as a regulator of the small GTPase Rho family in cytokinesis and cell differentiation". Cell Struct. Funct. 26 (6): 645–51. PMID 11942621.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Obuse C, Yang H, Nozaki N; et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. PMID 15009096.
- Matuliene J, Kuriyama R (2005). "Role of the midbody matrix in cytokinesis: RNAi and genetic rescue analysis of the mammalian motor protein CHO1". Mol. Biol. Cell. 15 (7): 3083–94. doi:10.1091/mbc.E03-12-0888. PMID 15075367.
- Liu X, Zhou T, Kuriyama R, Erikson RL (2005). "Molecular interactions of Polo-like-kinase 1 with the mitotic kinesin-like protein CHO1/MKLP-1". J. Cell. Sci. 117 (Pt 15): 3233–46. doi:10.1242/jcs.01173. PMID 15199097.
- Kurasawa Y, Earnshaw WC, Mochizuki Y; et al. (2005). "Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation". EMBO J. 23 (16): 3237–48. doi:10.1038/sj.emboj.7600347. PMID 15297875.
- Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
- Jin J, Smith FD, Stark C; et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Rush J, Moritz A, Lee KA; et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
- Benzinger A, Muster N, Koch HB; et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
- Zhu C, Bossy-Wetzel E, Jiang W (2005). "Recruitment of MKLP1 to the spindle midzone/midbody by INCENP is essential for midbody formation and completion of cytokinesis in human cells". Biochem. J. 389 (Pt 2): 373–81. doi:10.1042/BJ20050097. PMID 15796717.
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