KIF21A: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
imported>Jmertel23
m (added wikilinks and removed "underlinked" tag)
 
(One intermediate revision by one other user not shown)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{Infobox_gene}}
{{GNF_Protein_box
'''Kinesin-like protein KIF21A''' is a [[protein]] that in humans is encoded by the ''KIF21A'' [[gene]].<ref name="pmid10225949">{{cite journal |vauthors=Marszalek JR, Weiner JA, Farlow SJ, Chun J, Goldstein LS | title = Novel dendritic kinesin sorting identified by different process targeting of two related kinesins: KIF21A and KIF21B | journal = J Cell Biol | volume = 145 | issue = 3 | pages = 469–479 |date=Jun 1999 | pmid = 10225949 | pmc = 2185086 | doi =10.1083/jcb.145.3.469 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KIF21A kinesin family member 21A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55605| accessdate = }}</ref>
| image = 
| image_source = 
| PDB =
| Name = Kinesin family member 21A
| HGNCid = 19349
| Symbol = KIF21A
| AltSymbols =; CFEOM; CFEOM1; DKFZp779C159; FEOM; FEOM1; FLJ20052; KIAA1708
| OMIM = 608283
| ECnumber = 
| Homologene = 56761
| MGIid = 109188
| GeneAtlas_image1 = PBB_GE_KIF21A_gnf1h05980_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003777 |text = microtubule motor activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}}
| Component = {{GNF_GO|id=GO:0005874 |text = microtubule}} {{GNF_GO|id=GO:0005875 |text = microtubule associated complex}}
  | Process = {{GNF_GO|id=GO:0007018 |text = microtubule-based movement}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 55605
    | Hs_Ensembl = ENSG00000139116
    | Hs_RefseqProtein = NP_060111
    | Hs_RefseqmRNA = NM_017641
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 37973298
    | Hs_GenLoc_end = 38123185
    | Hs_Uniprot = Q7Z4S6
    | Mm_EntrezGene = 16564
    | Mm_Ensembl = ENSMUSG00000022629
    | Mm_RefseqmRNA = NM_016705
    | Mm_RefseqProtein = NP_057914
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 90762217
    | Mm_GenLoc_end = 90825824
    | Mm_Uniprot = Q8BXG5
  }}
}}
'''Kinesin family member 21A''', also known as '''KIF21A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KIF21A kinesin family member 21A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55605| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = KIF21A belongs to a family of plus end-directed kinesin (see MIM 600025) motor proteins. Neurons use kinesin and dynein (see MIM 600112) microtubule-dependent motor proteins to transport essential cellular components along axonal and dendritic microtubules.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: KIF21A kinesin family member 21A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55605| accessdate = }}</ref>
| summary_text = KIF21A belongs to a family of plus end-directed [[kinesin]] (see MIM 600025) motor proteins. [[Neurons]] use kinesin and [[dynein]] (see MIM 600112) microtubule-dependent [[motor proteins]] to transport essential cellular components along axonal and dendritic [[microtubules]].[supplied by OMIM]<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin|2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Yamada K, Hunter DG, Andrews C, Engle EC |title=A novel KIF21A mutation in a patient with congenital fibrosis of the extraocular muscles and Marcus Gunn jaw-winking phenomenon. |journal=Arch. Ophthalmol. |volume=123 |issue= 9 |pages= 1254-9 |year= 2005 |pmid= 16157808 |doi= 10.1001/archopht.123.9.1254 }}
*{{cite journal  |vauthors=Yamada K, Hunter DG, Andrews C, Engle EC |title=A novel KIF21A mutation in a patient with congenital fibrosis of the extraocular muscles and Marcus Gunn jaw-winking phenomenon |journal=Arch. Ophthalmol. |volume=123 |issue= 9 |pages= 1254–1259 |year= 2005 |pmid= 16157808 |doi= 10.1001/archopht.123.9.1254 }}
*{{cite journal  | author=Engle EC, Kunkel LM, Specht LA, Beggs AH |title=Mapping a gene for congenital fibrosis of the extraocular muscles to the centromeric region of chromosome 12. |journal=Nat. Genet. |volume=7 |issue= 1 |pages= 69-73 |year= 1994 |pmid= 8075644 |doi= 10.1038/ng0594-69 }}
*{{cite journal  |vauthors=Engle EC, Kunkel LM, Specht LA, Beggs AH |title=Mapping a gene for congenital fibrosis of the extraocular muscles to the centromeric region of chromosome 12 |journal=Nat. Genet. |volume=7 |issue= 1 |pages= 69–73 |year= 1994 |pmid= 8075644 |doi= 10.1038/ng0594-69 }}
*{{cite journal  | author=Ishikawa K, Nagase T, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 3 |pages= 169-76 |year= 1998 |pmid= 9734811 |doi= }}
*{{cite journal  | author=Ishikawa K |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro |journal=DNA Res. |volume=5 |issue= 3 |pages= 169–176 |year= 1998 |pmid= 9734811 |doi=10.1093/dnares/5.3.169 |name-list-format=vanc| author2=Nagase T  | author3=Suyama M  | display-authors=3  | last4=Miyajima  | first4=N  | last5=Tanaka  | first5=A  | last6=Kotani  | first6=H  | last7=Nomura  | first7=N  | last8=Ohara  | first8=O }}
*{{cite journal | author=Marszalek JR, Weiner JA, Farlow SJ, ''et al.'' |title=Novel dendritic kinesin sorting identified by different process targeting of two related kinesins: KIF21A and KIF21B. |journal=J. Cell Biol. |volume=145 |issue= 3 |pages= 469-79 |year= 1999 |pmid= 10225949 |doi=  }}
*{{cite journal  | author=Scanlan MJ |title=Antigens recognized by autologous antibody in patients with renal-cell carcinoma |journal=Int. J. Cancer |volume=83 |issue= 4 |pages= 456–464 |year= 1999 |pmid= 10508479 |doi=10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 |name-list-format=vanc| author2=Gordan JD  | author3=Williamson B  | display-authors=3  | last4=Stockert  | first4=Elisabeth  | last5=Bander  | first5=Neil H. | last6=Jongeneel  | first6=Victor  | last7=Gure  | first7=Ali O.  | last8=Jäger  | first8=Dirk  | last9=Jäger  | first9=Elke }}
*{{cite journal  | author=Scanlan MJ, Gordan JD, Williamson B, ''et al.'' |title=Antigens recognized by autologous antibody in patients with renal-cell carcinoma. |journal=Int. J. Cancer |volume=83 |issue= 4 |pages= 456-64 |year= 1999 |pmid= 10508479 |doi=  }}
*{{cite journal  | author=Nagase T |title=Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=7 |issue= 6 |pages= 347–355 |year= 2001 |pmid= 11214970 |doi=10.1093/dnares/7.6.347 |name-list-format=vanc| author2=Kikuno R  | author3=Hattori A | display-authors=3  | last4=Kondo  | first4=Y  | last5=Okumura  | first5=K | last6=Ohara  | first6=O }}
*{{cite journal  | author=Nagase T, Kikuno R, Hattori A, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 6 |pages= 347-55 |year= 2001 |pmid= 11214970 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Magli A, de Berardinis T, D'Esposito F, Gagliardi V |title=Clinical and surgical data of affected members of a classic CFEOM I family |journal=BMC Ophthalmology |volume=3|pages= 6 |year= 2004 |pmid= 12702216 |doi= | pmc=155649 }}
*{{cite journal | author=Magli A, de Berardinis T, D'Esposito F, Gagliardi V |title=Clinical and surgical data of affected members of a classic CFEOM I family. |journal=BMC ophthalmology |volume=3 |issue=  |pages= 6 |year= 2004 |pmid= 12702216 |doi=  }}
*{{cite journal  | author=Yamada K |title=Heterozygous mutations of the kinesin KIF21A in congenital fibrosis of the extraocular muscles type 1 (CFEOM1) |journal=Nat. Genet. |volume=35 |issue= 4 |pages= 318–321 |year= 2004 |pmid= 14595441 |doi= 10.1038/ng1261  |name-list-format=vanc| author2=Andrews C  | author3=Chan WM | display-authors=3  | last4=McKeown  | first4=Craig A  | last5=Magli  | first5=Adriano  | last6=De Berardinis  | first6=Teresa  | last7=Loewenstein  | first7=Anat  | last8=Lazar  | first8=Moshe  | last9=O'Keefe  | first9=Michael }}
*{{cite journal  | author=Yamada K, Andrews C, Chan WM, ''et al.'' |title=Heterozygous mutations of the kinesin KIF21A in congenital fibrosis of the extraocular muscles type 1 (CFEOM1). |journal=Nat. Genet. |volume=35 |issue= 4 |pages= 318-21 |year= 2004 |pmid= 14595441 |doi= 10.1038/ng1261 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Yamada K |title=Identification of KIF21A mutations as a rare cause of congenital fibrosis of the extraocular muscles type 3 (CFEOM3) |journal=Invest. Ophthalmol. Vis. Sci. |volume=45 |issue= 7 |pages= 2218–2223 |year= 2004 |pmid= 15223798 |doi=10.1167/iovs.03-1413 |name-list-format=vanc| author2=Chan WM  | author3=Andrews C  | display-authors=3  | last4=Bosley  | first4=TM  | last5=Sener  | first5=EC  | last6=Zwaan  | first6=JT  | last7=Mullaney  | first7=PB  | last8=Oztürk  | first8=BT  | last9=Akarsu  | first9=AN  }}
*{{cite journal  | author=Yamada K, Chan WM, Andrews C, ''et al.'' |title=Identification of KIF21A mutations as a rare cause of congenital fibrosis of the extraocular muscles type 3 (CFEOM3). |journal=Invest. Ophthalmol. Vis. Sci. |volume=45 |issue= 7 |pages= 2218-23 |year= 2004 |pmid= 15223798 |doi=  }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Tiab L |title=Mutation analysis of KIF21A in congenital fibrosis of the extraocular muscles (CFEOM) patients |journal=Ophthalmic Genet. |volume=25 |issue= 4 |pages= 241–246 |year= 2005 |pmid= 15621876 |doi= 10.1080/13816810490902828  |name-list-format=vanc| author2=d'Allèves Manzi V  | author3=Borruat FX  | display-authors=3  | last4=Munier  | first4=Francis  | last5=Schorderet  | first5=Daniel }}
*{{cite journal | author=Tiab L, d'Allèves Manzi V, Borruat FX, ''et al.'' |title=Mutation analysis of KIF21A in congenital fibrosis of the extraocular muscles (CFEOM) patients. |journal=Ophthalmic Genet. |volume=25 |issue= 4 |pages= 241-6 |year= 2005 |pmid= 15621876 |doi= 10.1080/13816810490902828 }}
*{{cite journal  |vauthors=Ali M, Venkatesh C, Ragunath A, Kumar A |title=Mutation analysis of the KIF21A gene in an Indian family with CFEOM1: implication of CpG methylation for most frequent mutations |journal=Ophthalmic Genet. |volume=25 |issue= 4 |pages= 247–255 |year= 2005 |pmid= 15621877 |doi= 10.1080/13816810490498198 }}
*{{cite journal  | author=Ali M, Venkatesh C, Ragunath A, Kumar A |title=Mutation analysis of the KIF21A gene in an Indian family with CFEOM1: implication of CpG methylation for most frequent mutations. |journal=Ophthalmic Genet. |volume=25 |issue= 4 |pages= 247-55 |year= 2005 |pmid= 15621877 |doi= 10.1080/13816810490498198 }}
*{{cite journal  |vauthors=Demer JL, Clark RA, Engle EC |title=Magnetic resonance imaging evidence for widespread orbital dysinnervation in congenital fibrosis of extraocular muscles due to mutations in KIF21A |journal=Invest. Ophthalmol. Vis. Sci. |volume=46 |issue= 2 |pages= 530–539 |year= 2005 |pmid= 15671279 |doi= 10.1167/iovs.04-1125 }}
*{{cite journal | author=Demer JL, Clark RA, Engle EC |title=Magnetic resonance imaging evidence for widespread orbital dysinnervation in congenital fibrosis of extraocular muscles due to mutations in KIF21A. |journal=Invest. Ophthalmol. Vis. Sci. |volume=46 |issue= 2 |pages= 530-9 |year= 2005 |pmid= 15671279 |doi= 10.1167/iovs.04-1125 }}
*{{cite journal  | author=Lin LK |title=KIF21A gene c.2860C>T mutation in congenital fibrosis of extraocular muscles type 1 and 3 |journal=Mol. Vis. |volume=11 |issue=  |pages= 245–8 |year= 2006 |pmid= 15827546 |doi=  |name-list-format=vanc| author2=Chien YH  | author3=Wu JY  | display-authors=3  | last4=Wang  | first4=AH  | last5=Chiang  | first5=SC  | last6=Hwu  | first6=WL  }}
*{{cite journal  | author=Lin LK, Chien YH, Wu JY, ''et al.'' |title=KIF21A gene c.2860C>T mutation in congenital fibrosis of extraocular muscles type 1 and 3. |journal=Mol. Vis. |volume=11 |issue= |pages= 245-8 |year= 2006 |pmid= 15827546 |doi= }}
*{{cite journal  |vauthors=Shimizu S, Okinaga A, Maruo T |title=Recurrent mutation of the KIF21A gene in Japanese patients with congenital fibrosis of the extraocular muscles |journal=Jpn. J. Ophthalmol. |volume=49 |issue= 6 |pages= 443–447 |year= 2006 |pmid= 16365788 |doi= 10.1007/s10384-005-0243-7 }}
*{{cite journal | author=Shimizu S, Okinaga A, Maruo T |title=Recurrent mutation of the KIF21A gene in Japanese patients with congenital fibrosis of the extraocular muscles. |journal=Jpn. J. Ophthalmol. |volume=49 |issue= 6 |pages= 443-7 |year= 2006 |pmid= 16365788 |doi= 10.1007/s10384-005-0243-7 }}
*{{cite journal  | author=Chan WM |title=Three novel mutations in KIF21A highlight the importance of the third coiled-coil stalk domain in the etiology of CFEOM1 |journal=BMC Genet. |volume=8|pages= 26 |year= 2007 |pmid= 17511870 |doi= 10.1186/1471-2156-8-26  | pmc=1888713  |name-list-format=vanc| author2=Andrews C  | author3=Dragan L  | display-authors=3  | last4=Fredrick  | first4=Douglas  | last5=Armstrong  | first5=Linlea  | last6=Lyons  | first6=Christopher  | last7=Geraghty  | first7=Michael T  | last8=Hunter  | first8=David G  | last9=Yazdani | first9=Ahmad }}
*{{cite journal  | author=Chan WM, Andrews C, Dragan L, ''et al.'' |title=Three novel mutations in KIF21A highlight the importance of the third coiled-coil stalk domain in the etiology of CFEOM1. |journal=BMC Genet. |volume=8 |issue=  |pages= 26 |year= 2007 |pmid= 17511870 |doi= 10.1186/1471-2156-8-26 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* [https://web.archive.org/web/20100306000036/http://www.childrenshospital.org/cfapps/research/data_admin/Site339/mainpageS339P18sublevel13.html Engle Laboratory CFEOM page]
*[https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=cfeom  GeneReviews/NCBI/NIH/UW entry on Congenital Fibrosis of the Extraocular Muscles]
* [https://www.ncbi.nlm.nih.gov/omim/135700,600638,602078,602661,602753,608283,609384,609428  OMIM entries on Congenital Fibrosis of the Extraocular Muscles]
 
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
 
{{gene-12-stub}}

Latest revision as of 15:38, 16 February 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Kinesin-like protein KIF21A is a protein that in humans is encoded by the KIF21A gene.[1][2]

KIF21A belongs to a family of plus end-directed kinesin (see MIM 600025) motor proteins. Neurons use kinesin and dynein (see MIM 600112) microtubule-dependent motor proteins to transport essential cellular components along axonal and dendritic microtubules.[supplied by OMIM][2]

References

  1. ↑ Marszalek JR, Weiner JA, Farlow SJ, Chun J, Goldstein LS (Jun 1999). "Novel dendritic kinesin sorting identified by different process targeting of two related kinesins: KIF21A and KIF21B". J Cell Biol. 145 (3): 469–479. doi:10.1083/jcb.145.3.469. PMC 2185086. PMID 10225949.
  2. ↑ 2.0 2.1 "Entrez Gene: KIF21A kinesin family member 21A".

Further reading

External links



Retrieved from "https://www.wikidoc.org/index.php?title=KIF21A&oldid=1528527"