KIF20A: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Kinesin-like protein KIF20A''' is a [[protein]] that in humans is encoded by the ''KIF20A'' [[gene]].<ref name="pmid11416179">{{cite journal | vauthors = Miki H, Setou M, Kaneshiro K, Hirokawa N | title = All kinesin superfamily protein, KIF, genes in mouse and human | journal = Proc Natl Acad Sci U S A | volume = 98 | issue = 13 | pages = 7004–11 | date = June 2001 | pmid = 11416179 | pmc = 34614 | doi = 10.1073/pnas.111145398 }}</ref><ref name="pmid10806357">{{cite journal | vauthors = Lai F, Fernald AA, Zhao N, Le Beau MM | title = cDNA cloning, expression pattern, genomic structure and chromosomal location of RAB6KIFL, a human kinesin-like gene | journal = Gene | volume = 248 | issue = 1–2 | pages = 117–25 | date = July 2000 | pmid = 10806357 | pmc =  | doi = 10.1016/S0378-1119(00)00135-9 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KIF20A kinesin family member 20A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10112| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Kinesin family member 20A
| HGNCid = 9787
| Symbol = KIF20A
| AltSymbols =; MKLP2; FLJ21151; RAB6KIFL
| OMIM = 605664
| ECnumber = 
| Homologene = 38093
| MGIid = 1201682
| GeneAtlas_image1 = PBB_GE_KIF20A_218755_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003777 |text = microtubule motor activity}} {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}}
| Component = {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0005874 |text = microtubule}} {{GNF_GO|id=GO:0005875 |text = microtubule associated complex}}
| Process = {{GNF_GO|id=GO:0007018 |text = microtubule-based movement}} {{GNF_GO|id=GO:0015031 |text = protein transport}} {{GNF_GO|id=GO:0016192 |text = vesicle-mediated transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10112
    | Hs_Ensembl = ENSG00000112984
    | Hs_RefseqProtein = NP_005724
    | Hs_RefseqmRNA = NM_005733
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 137542757
    | Hs_GenLoc_end = 137551304
    | Hs_Uniprot = O95235
    | Mm_EntrezGene = 19348
    | Mm_Ensembl = ENSMUSG00000003779
    | Mm_RefseqmRNA = NM_009004
    | Mm_RefseqProtein = NP_033030
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 34749796
    | Mm_GenLoc_end = 34758078
    | Mm_Uniprot = P97329
  }}
}}
'''Kinesin family member 20A''', also known as '''KIF20A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KIF20A kinesin family member 20A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10112| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
KIF20A has been shown to [[Protein-protein interaction|interact]] with [[RAB6A]].<ref name = pmid9438855>{{cite journal | vauthors = Echard A, Jollivet F, Martinez O, Lacapère JJ, Rousselet A, Janoueix-Lerosey I, Goud B | title = Interaction of a Golgi-associated kinesin-like protein with Rab6 | journal = Science | volume = 279 | issue = 5350 | pages = 580–5 | date = January 1998 | pmid = 9438855 | doi = 10.1126/science.279.5350.580 }}</ref><ref name = pmid11071909>{{cite journal | vauthors = Echard A, Opdam FJ, de Leeuw HJ, Jollivet F, Savelkoul P, Hendriks W, Voorberg J, Goud B, Fransen JA | title = Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms | journal = Mol. Biol. Cell | volume = 11 | issue = 11 | pages = 3819–33 | date = November 2000 | pmid = 11071909 | pmc = 15039 | doi = 10.1091/mbc.11.11.3819 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Echard A, Jollivet F, Martinez O, Lacapère JJ, Rousselet A, Janoueix-Lerosey I, Goud B | title = Interaction of a Golgi-associated kinesin-like protein with Rab6 | journal = Science | volume = 279 | issue = 5350 | pages = 580–5 | year = 1998 | pmid = 9438855 | doi = 10.1126/science.279.5350.580 }}
| citations =
* {{cite journal | vauthors = Horrevoets AJ, Fontijn RD, van Zonneveld AJ, de Vries CJ, ten Cate JW, Pannekoek H | title = Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes | journal = Blood | volume = 93 | issue = 10 | pages = 3418–31 | year = 1999 | pmid = 10233894 | doi =  }}
*{{cite journal | author=Miki H, Setou M, Kaneshiro K, Hirokawa N |title=All kinesin superfamily protein, KIF, genes in mouse and human. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 13 |pages= 7004-11 |year= 2001 |pmid= 11416179 |doi= 10.1073/pnas.111145398 }}
* {{cite journal | vauthors = Opdam FJ, Echard A, Croes HJ, van den Hurk JA, van de Vorstenbosch RA, Ginsel LA, Goud B, Fransen JA | title = The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus | journal = J. Cell Sci. | volume = 113 | issue = 15 | pages = 2725–35 | year = 2000 | pmid = 10893188 | doi =  }}
*{{cite journal  | author=Echard A, Jollivet F, Martinez O, ''et al.'' |title=Interaction of a Golgi-associated kinesin-like protein with Rab6. |journal=Science |volume=279 |issue= 5350 |pages= 580-5 |year= 1998 |pmid= 9438855 |doi= }}
* {{cite journal | vauthors = Hill E, Clarke M, Barr FA | title = The Rab6-binding kinesin, Rab6-KIFL, is required for cytokinesis | journal = EMBO J. | volume = 19 | issue = 21 | pages = 5711–9 | year = 2000 | pmid = 11060022 | pmc = 305783 | doi = 10.1093/emboj/19.21.5711 }}
*{{cite journal | author=Horrevoets AJ, Fontijn RD, van Zonneveld AJ, ''et al.'' |title=Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes. |journal=Blood |volume=93 |issue= 10 |pages= 3418-31 |year= 1999 |pmid= 10233894 |doi=  }}
* {{cite journal | vauthors = Echard A, Opdam FJ, de Leeuw HJ, Jollivet F, Savelkoul P, Hendriks W, Voorberg J, Goud B, Fransen JA | title = Alternative Splicing of the Human Rab6A Gene Generates Two Close but Functionally Different Isoforms | journal = Mol. Biol. Cell | volume = 11 | issue = 11 | pages = 3819–33 | year = 2001 | pmid = 11071909 | pmc = 15039 | doi = 10.1091/mbc.11.11.3819 }}
*{{cite journal | author=Lai F, Fernald AA, Zhao N, Le Beau MM |title=cDNA cloning, expression pattern, genomic structure and chromosomal location of RAB6KIFL, a human kinesin-like gene. |journal=Gene |volume=248 |issue= 1-2 |pages= 117-25 |year= 2000 |pmid= 10806357 |doi=  }}
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA Cloning Using In Vitro Site-Specific Recombination | journal = Genome Res. | volume = 10 | issue = 11 | pages = 1788–95 | year = 2001 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
*{{cite journal  | author=Opdam FJ, Echard A, Croes HJ, ''et al.'' |title=The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus. |journal=J. Cell. Sci. |volume=113 ( Pt 15) |issue= |pages= 2725-35 |year= 2000 |pmid= 10893188 |doi=  }}
* {{cite journal | vauthors = Nagura M, Nagao Y, Takita J, Igarashi T, LeGuern E, Hayashi Y | title = The kinesin superfamily protein Rab6KIFL is not involved in the pathophysiology of Charcot-Marie-Tooth disease type 4C | journal = Int. J. Mol. Med. | volume = 11 | issue = 1 | pages = 45–7 | year = 2003 | pmid = 12469216 | doi = 10.3892/ijmm.11.1.45 }}
*{{cite journal | author=Hill E, Clarke M, Barr FA |title=The Rab6-binding kinesin, Rab6-KIFL, is required for cytokinesis. |journal=EMBO J. |volume=19 |issue= 21 |pages= 5711-9 |year= 2000 |pmid= 11060022 |doi= 10.1093/emboj/19.21.5711 }}
* {{cite journal | vauthors = Neef R, Preisinger C, Sutcliffe J, Kopajtich R, Nigg EA, Mayer TU, Barr FA | title = Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis | journal = J. Cell Biol. | volume = 162 | issue = 5 | pages = 863–75 | year = 2003 | pmid = 12939256 | pmc = 2172827 | doi = 10.1083/jcb.200306009 }}
*{{cite journal | author=Echard A, Opdam FJ, de Leeuw HJ, ''et al.'' |title=Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms. |journal=Mol. Biol. Cell |volume=11 |issue= 11 |pages= 3819-33 |year= 2001 |pmid= 11071909 |doi= }}
* {{cite journal | vauthors = Gruneberg U, Neef R, Honda R, Nigg EA, Barr FA | title = Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2 | journal = J. Cell Biol. | volume = 166 | issue = 2 | pages = 167–72 | year = 2004 | pmid = 15263015 | pmc = 2172317 | doi = 10.1083/jcb.200403084 }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
* {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to Biology: A Functional Genomics Pipeline | journal = Genome Res. | volume = 14 | issue = 10B | pages = 2136–44 | year = 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}
*{{cite journal | author=Nagura M, Nagao Y, Takita J, ''et al.'' |title=The kinesin superfamily protein Rab6KIFL is not involved in the pathophysiology of Charcot-Marie-Tooth disease type 4C. |journal=Int. J. Mol. Med. |volume=11 |issue= 1 |pages= 45-7 |year= 2003 |pmid= 12469216 |doi= }}
* {{cite journal | vauthors = Taniuchi K, Nakagawa H, Nakamura T, Eguchi H, Ohigashi H, Ishikawa O, Katagiri T, Nakamura Y | title = Down-regulation of RAB6KIFL/KIF20A, a kinesin involved with membrane trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cell | journal = Cancer Res. | volume = 65 | issue = 1 | pages = 105–12 | year = 2005 | pmid = 15665285 | doi =  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | title = The LIFEdb database in 2006 | journal = Nucleic Acids Res. | volume = 34 | issue = Database issue | pages = D415–8 | year = 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }}
*{{cite journal | author=Neef R, Preisinger C, Sutcliffe J, ''et al.'' |title=Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis. |journal=J. Cell Biol. |volume=162 |issue= 5 |pages= 863-75 |year= 2003 |pmid= 12939256 |doi= 10.1083/jcb.200306009 }}
* {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 14 | pages = 5391–6 | year = 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 }}
*{{cite journal | author=Gruneberg U, Neef R, Honda R, ''et al.'' |title=Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2. |journal=J. Cell Biol. |volume=166 |issue= 2 |pages= 167-72 |year= 2004 |pmid= 15263015 |doi= 10.1083/jcb.200403084 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal | author=Taniuchi K, Nakagawa H, Nakamura T, ''et al.'' |title=Down-regulation of RAB6KIFL/KIF20A, a kinesin involved with membrane trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cell. |journal=Cancer Res. |volume=65 |issue= 1 |pages= 105-12 |year= 2005 |pmid= 15665285 |doi=  }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal | author=Nousiainen M, Silljé HH, Sauer G, ''et al.'' |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391-6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* {{UCSC genome browser|KIF20A}}
* {{UCSC gene details|KIF20A}}
 
 
{{gene-5-stub}}

Latest revision as of 20:10, 8 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Kinesin-like protein KIF20A is a protein that in humans is encoded by the KIF20A gene.[1][2][3]

Interactions

KIF20A has been shown to interact with RAB6A.[4][5]

References

  1. Miki H, Setou M, Kaneshiro K, Hirokawa N (June 2001). "All kinesin superfamily protein, KIF, genes in mouse and human". Proc Natl Acad Sci U S A. 98 (13): 7004–11. doi:10.1073/pnas.111145398. PMC 34614. PMID 11416179.
  2. Lai F, Fernald AA, Zhao N, Le Beau MM (July 2000). "cDNA cloning, expression pattern, genomic structure and chromosomal location of RAB6KIFL, a human kinesin-like gene". Gene. 248 (1–2): 117–25. doi:10.1016/S0378-1119(00)00135-9. PMID 10806357.
  3. "Entrez Gene: KIF20A kinesin family member 20A".
  4. Echard A, Jollivet F, Martinez O, Lacapère JJ, Rousselet A, Janoueix-Lerosey I, Goud B (January 1998). "Interaction of a Golgi-associated kinesin-like protein with Rab6". Science. 279 (5350): 580–5. doi:10.1126/science.279.5350.580. PMID 9438855.
  5. Echard A, Opdam FJ, de Leeuw HJ, Jollivet F, Savelkoul P, Hendriks W, Voorberg J, Goud B, Fransen JA (November 2000). "Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms". Mol. Biol. Cell. 11 (11): 3819–33. doi:10.1091/mbc.11.11.3819. PMC 15039. PMID 11071909.

Further reading

External links