KIF1C

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
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Kinesin-like protein KIF1C is a protein that in humans is encoded by the KIF1C gene.[1][2] Kif1C is a fast, non-processive, plus-end directed microtubule motor.[3] Kif1C transports α5β1-integrins in human cells.[4] Kif1C has been shown to be non-essential in mouse with other proteins able to perform the same function.[5]

Interactions

KIF1C has been shown to interact with PTPN21[1] and YWHAG.[6]

References

  1. 1.0 1.1 Dorner C, Ciossek T, Muller S, Moller PH, Ullrich A, Lammers R (Sep 1998). "Characterization of KIF1C, a new kinesin-like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum". J Biol Chem. 273 (32): 20267–75. doi:10.1074/jbc.273.32.20267. PMID 9685376.
  2. "Entrez Gene: KIF1C kinesin family member 1C".
  3. Rogers KR, Weiss S, Crevel I, Brophy PJ, Geeves M, Cross R (September 2001). "KIF1D is a fast non-processive kinesin that demonstrates novel K-loop-dependent mechanochemistry". EMBO J. 20 (18): 5101–13. doi:10.1093/emboj/20.18.5101. PMC 125638. PMID 11566875.
  4. Theisen U, Straube E, Straube A (December 2012). "Directional persistence of migrating cells requires Kif1C-mediated stabilization of trailing adhesions". Dev. Cell. 23 (6): 1153–66. doi:10.1016/j.devcel.2012.11.005. PMID 23237952.
  5. Kazuo N, Yosuke T, Yosuke T, Terunaga N, Takao N, Yasuko N, Mitsutoshi S, Nobutaka H (February 2002). "Molecular Motor KIF1C Is Not Essential for Mouse Survival and Motor-Dependent Retrograde Golgi Apparatus-to-Endoplasmic Reticulum Transport". Molecular and Cell Biology. 38 (13): 866–873. doi:10.1128/MCB.22.3.866-873.2002. PMC 133549.
  6. Dorner C, Ullrich A, Häring HU, Lammers R (November 1999). "The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family". J. Biol. Chem. 274 (47): 33654–60. doi:10.1074/jbc.274.47.33654. PMID 10559254.

Further reading