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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6''' is an [[enzyme]] that in humans is encoded by the ''JMJD6'' [[gene]].<ref name="pmid11877474">{{cite journal | vauthors = Vandivier RW, Fadok VA, Hoffmann PR, Bratton DL, Penvari C, Brown KK, Brain JD, Accurso FJ, Henson PM | title = Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis | journal = The Journal of Clinical Investigation | volume = 109 | issue = 5 | pages = 661–70 | date = March 2002 | pmid = 11877474 | pmc = 150889 | doi = 10.1172/JCI13572 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: JMJD6 jumonji domain containing 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23210| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Jumonji domain containing 6
| HGNCid = 19355
| Symbol = JMJD6
| AltSymbols =; KIAA0585; PSR; PTDSR; PTDSR1
| OMIM = 604914
| ECnumber = 
| Homologene = 9046
| MGIid = 1858910
| GeneAtlas_image1 = PBB_GE_JMJD6_212722_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_JMJD6_215233_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0001568 |text = blood vessel development}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23210
    | Hs_Ensembl = ENSG00000070495
    | Hs_RefseqProtein = NP_001074930
    | Hs_RefseqmRNA = NM_001081461
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 72220514
    | Hs_GenLoc_end = 72234158
    | Hs_Uniprot = Q6NYC1
    | Mm_EntrezGene = 107817
    | Mm_Ensembl = ENSMUSG00000056962
    | Mm_RefseqmRNA = NM_033398
    | Mm_RefseqProtein = NP_203971
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 116653523
    | Mm_GenLoc_end = 116659539
    | Mm_Uniprot = Q9ERI5
  }}
}}
'''Jumonji domain containing 6''', also known as '''JMJD6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: JMJD6 jumonji domain containing 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23210| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a nuclear protein with a [[JmjC domain]]. JmjC domain-containing proteins belong to the [[2-oxoglutarate (2OG)-dependent dioxygenases | 2-oxoglutarate (2OG)-dependent dioxygenase]] superfamily. They are predicted to function as protein [[hydroxylase]]s or histone demethylases. This protein was first identified as a putative [[phosphatidylserine]] receptor involved in [[phagocytosis]] of [[Apoptosis|apoptotic cells]]; however, subsequent studies have suggested that the protein may cross-react with a monoclonal antibody that recognizes the phosphatidylserine receptor and does not directly function in the clearance of apoptotic cells. Multiple transcript variants encoding different isoforms have been found for this gene.<ref name="entrez" /> JMJD6 has been implicated in mammary tumorigenesis, and it increases breast cancer aggressiveness and metastasis in mice.<ref name="aprelikova">{{cite journal | vauthors = Aprelikova O, Chen K, El Touny LH, Brignatz-Guittard C, Han J, Qiu T, Yang HH, Lee MP, Zhu M, Green JE | title = The epigenetic modifier JMJD6 is amplified in mammary tumors and cooperates with c-Myc to enhance cellular transformation, tumor progression, and metastasis | journal = Clin Epigenetics | volume = 8 | issue = 38 | date = 14 Apr 2016 | doi = 10.1186/s13148-016-0205-6 | url = http://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-016-0205-6 | accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have suggested that the protein may cross-react with a monoclonal antibody that recognizes the phosphatidylserine receptor and does not directly function in the clearance of apoptotic cells. Multiple transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: JMJD6 jumonji domain containing 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23210| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Boeckel JN, Guarani V, Koyanagi M, Roexe T, Lengeling A, Schermuly RT, Gellert P, Braun T, Zeiher A, Dimmeler S | title = Jumonji domain-containing protein 6 (Jmjd6) is required for angiogenic sprouting and regulates splicing of VEGF-receptor 1 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 108 | issue = 8 | pages = 3276–81 | date = February 2011 | pmid = 21300889 | doi = 10.1073/pnas.1008098108 | pmc=3044381}}
| citations =  
* {{cite journal | vauthors = Webby CJ, Wolf A, Gromak N, Dreger M, Kramer H, Kessler B, Nielsen ML, Schmitz C, Butler DS, Yates JR, Delahunty CM, Hahn P, Lengeling A, Mann M, Proudfoot NJ, Schofield CJ, Böttger A | title = Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing | journal = Science | volume = 325 | issue = 5936 | pages = 90–3 | date = July 2009 | pmid = 19574390 | doi = 10.1126/science.1175865 }}
*{{cite journal | author=Williamson P, Schlegel RA |title=Hide and seek: the secret identity of the phosphatidylserine receptor. |journal=J. Biol. |volume=3 |issue= 4 |pages= 14 |year= 2005 |pmid= 15453906 |doi= 10.1186/jbiol14 }}
* {{cite journal | vauthors = Zakharova L, Dadsetan S, Fomina AF | title = Endogenous Jmjd6 gene product is expressed at the cell surface and regulates phagocytosis in immature monocyte-like activated THP-1 cells | journal = Journal of Cellular Physiology | volume = 221 | issue = 1 | pages = 84–91 | date = October 2009 | pmid = 19492415 | doi = 10.1002/jcp.21829 }}
*{{cite journal | author=Nagase T, Ishikawa K, Miyajima N, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 1 |pages= 31-9 |year= 1998 |pmid= 9628581 |doi= }}
* {{cite journal | vauthors = Hahn P, Böse J, Edler S, Lengeling A | title = Genomic structure and expression of Jmjd6 and evolutionary analysis in the context of related JmjC domain containing proteins | journal = BMC Genomics | volume = 9 | pages = 293 | year = 2008 | pmid = 18564434 | pmc = 2453528 | doi = 10.1186/1471-2164-9-293 }}
*{{cite journal | author=Fadok VA, Bratton DL, Rose DM, ''et al.'' |title=A receptor for phosphatidylserine-specific clearance of apoptotic cells. |journal=Nature |volume=405 |issue= 6782 |pages= 85-90 |year= 2000 |pmid= 10811223 |doi= 10.1038/35011084 }}
* {{cite journal | vauthors = Chang B, Chen Y, Zhao Y, Bruick RK | title = JMJD6 is a histone arginine demethylase | journal = Science | volume = 318 | issue = 5849 | pages = 444–7 | date = October 2007 | pmid = 17947579 | doi = 10.1126/science.1145801 }}
*{{cite journal | author=Vandivier RW, Fadok VA, Hoffmann PR, ''et al.'' |title=Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. |journal=J. Clin. Invest. |volume=109 |issue= 5 |pages= 661-70 |year= 2002 |pmid= 11877474 |doi= }}
* {{cite journal | vauthors = Klose RJ, Kallin EM, Zhang Y | title = JmjC-domain-containing proteins and histone demethylation | journal = Nature Reviews Genetics | volume = 7 | issue = 9 | pages = 715–27 | date = September 2006 | pmid = 16983801 | doi = 10.1038/nrg1945 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Williamson P, Schlegel RA | title = Hide and seek: the secret identity of the phosphatidylserine receptor | journal = Journal of Biology | volume = 3 | issue = 4 | pages = 14 | year = 2005 | pmid = 15453906 | pmc = 549716 | doi = 10.1186/jbiol14 }}
*{{cite journal | author=Ajmone-Cat MA, De Simone R, Nicolini A, Minghetti L |title=Effects of phosphatidylserine on p38 mitogen activated protein kinase, cyclic AMP responding element binding protein and nuclear factor-kappaB activation in resting and activated microglial cells. |journal=J. Neurochem. |volume=84 |issue= 2 |pages= 413-6 |year= 2003 |pmid= 12559004 |doi= }}
* {{cite journal | vauthors = Böse J, Gruber AD, Helming L, Schiebe S, Wegener I, Hafner M, Beales M, Köntgen F, Lengeling A | title = The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal | journal = Journal of Biology | volume = 3 | issue = 4 | pages = 15 | year = 2005 | pmid = 15345036 | pmc = 549712 | doi = 10.1186/jbiol10 }}
*{{cite journal | author=Chan A, Seguin R, Magnus T, ''et al.'' |title=Phagocytosis of apoptotic inflammatory cells by microglia and its therapeutic implications: termination of CNS autoimmune inflammation and modulation by interferon-beta. |journal=Glia |volume=43 |issue= 3 |pages= 231-42 |year= 2003 |pmid= 12898702 |doi= 10.1002/glia.10258 }}
* {{cite journal | vauthors = Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 1 | pages = 31–9 | date = February 1998 | pmid = 9628581 | doi = 10.1093/dnares/5.1.31 }}
*{{cite journal | author=Wang X, Wu YC, Fadok VA, ''et al.'' |title=Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12. |journal=Science |volume=302 |issue= 5650 |pages= 1563-6 |year= 2003 |pmid= 14645848 |doi= 10.1126/science.1087641 }}
* {{cite journal | vauthors = Fadok VA, Bratton DL, Rose DM, Pearson A, Ezekewitz RA, Henson PM | title = A receptor for phosphatidylserine-specific clearance of apoptotic cells | journal = Nature | volume = 405 | issue = 6782 | pages = 85–90 | date = May 2000 | pmid = 10811223 | doi = 10.1038/35011084 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Ajmone-Cat MA, De Simone R, Nicolini A, Minghetti L | title = Effects of phosphatidylserine on p38 mitogen activated protein kinase, cyclic AMP responding element binding protein and nuclear factor-kappaB activation in resting and activated microglial cells | journal = Journal of Neurochemistry | volume = 84 | issue = 2 | pages = 413–6 | date = January 2003 | pmid = 12559004 | doi = 10.1046/j.1471-4159.2003.01562.x }}
*{{cite journal  | author=Cui P, Qin B, Liu N, ''et al.'' |title=Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals. |journal=Exp. Cell Res. |volume=293 |issue= 1 |pages= 154-63 |year= 2004 |pmid= 14729065 |doi= }}
* {{cite journal | vauthors = Chan A, Seguin R, Magnus T, Papadimitriou C, Toyka KV, Antel JP, Gold R | title = Phagocytosis of apoptotic inflammatory cells by microglia and its therapeutic implications: termination of CNS autoimmune inflammation and modulation by interferon-beta | journal = Glia | volume = 43 | issue = 3 | pages = 231–42 | date = September 2003 | pmid = 12898702 | doi = 10.1002/glia.10258 }}
*{{cite journal | author=Cao WM, Murao K, Imachi H, ''et al.'' |title=Phosphatidylserine receptor cooperates with high-density lipoprotein receptor in recognition of apoptotic cells by thymic nurse cells. |journal=J. Mol. Endocrinol. |volume=32 |issue= 2 |pages= 497-505 |year= 2005 |pmid= 15072554 |doi= }}
* {{cite journal | vauthors = Wang X, Wu YC, Fadok VA, Lee MC, Gengyo-Ando K, Cheng LC, Ledwich D, Hsu PK, Chen JY, Chou BK, Henson P, Mitani S, Xue D | title = Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12 | journal = Science | volume = 302 | issue = 5650 | pages = 1563–6 | date = November 2003 | pmid = 14645848 | doi = 10.1126/science.1087641 }}
*{{cite journal | author=Cikala M, Alexandrova O, David CN, ''et al.'' |title=The phosphatidylserine receptor from Hydra is a nuclear protein with potential Fe(II) dependent oxygenase activity. |journal=BMC Cell Biol. |volume=5 |issue=  |pages= 26 |year= 2004 |pmid= 15193161 |doi= 10.1186/1471-2121-5-26 }}
* {{cite journal | vauthors = Cui P, Qin B, Liu N, Pan G, Pei D | title = Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals | journal = Experimental Cell Research | volume = 293 | issue = 1 | pages = 154–63 | date = February 2004 | pmid = 14729065 | doi = 10.1016/j.yexcr.2003.09.023 }}
*{{cite journal | author=Böse J, Gruber AD, Helming L, ''et al.'' |title=The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal. |journal=J. Biol. |volume=3 |issue= 4 |pages= 15 |year= 2005 |pmid= 15345036 |doi= 10.1186/jbiol10 }}
* {{cite journal | vauthors = Cao WM, Murao K, Imachi H, Hiramine C, Abe H, Yu X, Dobashi H, Wong NC, Takahara J, Ishida T | title = Phosphatidylserine receptor cooperates with high-density lipoprotein receptor in recognition of apoptotic cells by thymic nurse cells | journal = Journal of Molecular Endocrinology | volume = 32 | issue = 2 | pages = 497–505 | date = April 2004 | pmid = 15072554 | doi = 10.1677/jme.0.0320497 }}
*{{cite journal  | author=Hong JR, Lin GH, Lin CJ, ''et al.'' |title=Phosphatidylserine receptor is required for the engulfment of dead apoptotic cells and for normal embryonic development in zebrafish. |journal=Development |volume=131 |issue= 21 |pages= 5417-27 |year= 2004 |pmid= 15469976 |doi= 10.1242/dev.01409 }}
* {{cite journal | vauthors = Cikala M, Alexandrova O, David CN, Pröschel M, Stiening B, Cramer P, Böttger A | title = The phosphatidylserine receptor from Hydra is a nuclear protein with potential Fe(II) dependent oxygenase activity | journal = BMC Cell Biology | volume = 5 | pages = 26 | date = June 2004 | pmid = 15193161 | pmc = 442123 | doi = 10.1186/1471-2121-5-26 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Hong JR, Lin GH, Lin CJ, Wang WP, Lee CC, Lin TL, Wu JL | title = Phosphatidylserine receptor is required for the engulfment of dead apoptotic cells and for normal embryonic development in zebrafish | journal = Development | volume = 131 | issue = 21 | pages = 5417–27 | date = November 2004 | pmid = 15469976 | doi = 10.1242/dev.01409 }}
*{{cite journal  | author=Köninger J, Balaz P, Wagner M, ''et al.'' |title=Phosphatidylserine receptor in chronic pancreatitis: evidence for a macrophage independent role. |journal=Ann. Surg. |volume=241 |issue= 1 |pages= 144-51 |year= 2005 |pmid= 15622002 |doi=  }}
* {{cite journal | vauthors = Köninger J, Balaz P, Wagner M, Shi X, Cima I, Zimmermann A, di Sebastiano P, Büchler MW, Friess H | title = Phosphatidylserine receptor in chronic pancreatitis: evidence for a macrophage independent role | journal = Annals of Surgery | volume = 241 | issue = 1 | pages = 144–51 | date = January 2005 | pmid = 15622002 | pmc = 1356857 | doi =  }}
*{{cite journal  | author=Klose RJ, Kallin EM, Zhang Y |title=JmjC-domain-containing proteins  and histone demethylation. |journal=Nat. Rev. Genet. |volume=7 |issue= 9 |pages= 715-27 |year= 2006 |pmid= 16983801 |doi=  }}
*{{cite journal  | author=Chang B, Chen Y, Zhao Y, Bruick RK |title=JMJD6 is a histone arginine demethylase. |journal=Science |volume=318 |issue= 5849 |pages= 444-7 |year= 2007 |pmid= 17947579 |doi= 10.1126/science.1145801 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Dioxygenases}}
{{WikiDoc Sources}}
{{Enzymes}}
{{Portal bar|Molecular and Cellular Biology|border=no}}
 
[[Category:Human 2OG oxygenases]]
[[Category:EC 1.14.11]]
 
 
{{gene-17-stub}}

Revision as of 09:36, 23 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 is an enzyme that in humans is encoded by the JMJD6 gene.[1][2]

Function

This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins belong to the 2-oxoglutarate (2OG)-dependent dioxygenase superfamily. They are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have suggested that the protein may cross-react with a monoclonal antibody that recognizes the phosphatidylserine receptor and does not directly function in the clearance of apoptotic cells. Multiple transcript variants encoding different isoforms have been found for this gene.[2] JMJD6 has been implicated in mammary tumorigenesis, and it increases breast cancer aggressiveness and metastasis in mice.[3]

References

  1. ↑ Vandivier RW, Fadok VA, Hoffmann PR, Bratton DL, Penvari C, Brown KK, Brain JD, Accurso FJ, Henson PM (March 2002). "Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis". The Journal of Clinical Investigation. 109 (5): 661–70. doi:10.1172/JCI13572. PMC 150889. PMID 11877474.
  2. ↑ 2.0 2.1 "Entrez Gene: JMJD6 jumonji domain containing 6".
  3. ↑ Aprelikova O, Chen K, El Touny LH, Brignatz-Guittard C, Han J, Qiu T, Yang HH, Lee MP, Zhu M, Green JE (14 Apr 2016). "The epigenetic modifier JMJD6 is amplified in mammary tumors and cooperates with c-Myc to enhance cellular transformation, tumor progression, and metastasis". Clin Epigenetics. 8 (38). doi:10.1186/s13148-016-0205-6.

Further reading


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