Isoflurane

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Isoflurane
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chetan Lokhande, M.B.B.S [2]

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Overview

Isoflurane is a general anesthetic that is FDA approved for the {{{indicationType}}} of general anesthesia. Common adverse reactions include gastrointestinal: nausea, vomiting.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

  • General anesthesia: induction, 1.5 to 3% isoflurane with oxygen or oxygen-nitrous oxide mixture.
  • General anesthesia: maintenance, 1 to 2.5% with nitrous oxide, additional 0.5 to 1% with oxygen alone.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information about Off-Label Guideline-Supported Use of Isoflurane in adult patients.

Non–Guideline-Supported Use

There is limited information about Off-Label Non–Guideline-Supported Use of Isoflurane in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

  • Safety in children under 2 yr of age has not been established
  • General anesthesia: dosage must be individualized

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information about Off-Label Guideline-Supported Use of Isoflurane in pediatric patients.

Non–Guideline-Supported Use

There is limited information about Off-Label Non–Guideline-Supported Use of Isoflurane in pediatric patients.

Contraindications

  • Known sensitivity to FORANE (isoflurane, USP) or to other halogenated agents. Known or suspected genetic susceptibility to malignant hyperthermia.

Warnings

There is limited information regarding Isoflurane Warnings' in the drug label.

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Isoflurane Clinical Trials Experience in the drug label.

Postmarketing Experience

There is limited information regarding Isoflurane Postmarketing Experience in the drug label.

Drug Interactions

There is limited information regarding Isoflurane Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): There is no FDA guidance on usage of Isoflurane in women who are pregnant.
Pregnancy Category (AUS): There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Isoflurane in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Isoflurane during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Isoflurane in women who are nursing.

Pediatric Use

There is no FDA guidance on the use of Isoflurane in pediatric settings.

Geriatic Use

There is no FDA guidance on the use of Isoflurane in geriatric settings.

Gender

There is no FDA guidance on the use of Isoflurane with respect to specific gender populations.

Race

There is no FDA guidance on the use of Isoflurane with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Isoflurane in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Isoflurane in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Isoflurane in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Isoflurane in patients who are immunocompromised.

Administration and Monitoring

Administration

There is limited information regarding Isoflurane Administration in the drug label.

Monitoring

There is limited information regarding Isoflurane Monitoring in the drug label.

IV Compatibility

There is limited information regarding the compatibility of Isoflurane and IV administrations.

Overdosage

There is limited information regarding Isoflurane overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.

Pharmacology

There is limited information regarding Isoflurane Pharmacology in the drug label.

Mechanism of Action

There is limited information regarding Isoflurane Mechanism of Action in the drug label.

Structure

There is limited information regarding Isoflurane Structure in the drug label.

Pharmacodynamics

There is limited information regarding Isoflurane Pharmacodynamics in the drug label.

Pharmacokinetics

There is limited information regarding Isoflurane Pharmacokinetics in the drug label.

Nonclinical Toxicology

There is limited information regarding Isoflurane Nonclinical Toxicology in the drug label.

Clinical Studies

There is limited information regarding Isoflurane Clinical Studies in the drug label.

How Supplied

There is limited information regarding Isoflurane How Supplied in the drug label.

Storage

There is limited information regarding Isoflurane Storage in the drug label.

Images

Drug Images

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Package and Label Display Panel

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Patient Counseling Information

There is limited information regarding Isoflurane Patient Counseling Information in the drug label.

Precautions with Alcohol

Alcohol-Isoflurane interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

There is limited information regarding Isoflurane Brand Names in the drug label.

Look-Alike Drug Names

There is limited information regarding Isoflurane Look-Alike Drug Names in the drug label.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.