Iodoquinol: Difference between revisions

Latest revision as of 23:59, 30 December 2013

Iodoquinol
YODOXIN^® Package Insert
Description
Inactive Ingredients
Action
Indications
Contraindications
Warnings
Use in Pregnancy
Precautions
Adverse Reactions
Dosage and Administration
How Supplied
Storage

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

The quinoline derivative diiodohydroxyquinoline (INN) or iodoquinol (USAN) can be used in the treatment of amebiasis, balantidiasis, and Dientamoeba fragilis.^[1] It is poorly absorbed from the gastrointestinal tract and is used as a luminal agent to eradicate both cysts and trophozoites infestating the lumen of the gastrointestinal tract. Iodoquinol is not recommended for prolonged use due to associated toxicities (eg, optic neuritis, optic atrophy, and peripheral neuropathy).

US Brand Names

YODOXIN^®

Package Insert

Mechanisms of Action

Iodoquinol acts by chelation of Fe²⁺ which is essential for metabolism.

References

↑ Ghaskadbi S, Vaidya VG (1989). "In vivo antimutagenic effect of ascorbic acid against mutagenicity of the common antiamebic drug diiodohydroxyquinoline". Mutat. Res. 222 (3): 219–22. doi:10.1016/0165-1218(89)90137-7. PMID 2493578. Unknown parameter |month= ignored (help)

[pmid2493578-1] Ghaskadbi S, Vaidya VG (1989). "In vivo antimutagenic effect of ascorbic acid against mutagenicity of the common antiamebic drug diiodohydroxyquinoline". Mutat. Res. 222 (3): 219–22. doi:10.1016/0165-1218(89)90137-7. PMID 2493578. Unknown parameter |month= ignored (help)

[1]

@@ Line 4: / Line 4: @@
 ==Overview==
-The [[quinoline]] derivative diiodohydroxyquinoline ([[International Nonproprietary Name|INN]]) or iodoquinol ([[United States Adopted Name|USAN]]) can be used in the treatment of [[amoebiasis]].<ref name="pmid2493578">{{cite journal |author=Ghaskadbi S, Vaidya VG |title=In vivo antimutagenic effect of ascorbic acid against mutagenicity of the common antiamebic drug diiodohydroxyquinoline |journal=Mutat. Res. |volume=222 |issue=3 |pages=219–22 |year=1989 |month=March |pmid=2493578 |doi= 10.1016/0165-1218(89)90137-7|url=}}</ref> It is poorly absorbed from the [[gastrointestinal tract]] and is used as a luminal amebicide. It was discovered by Adco Co. and introduced as ''diiodohydroxyquinoline''.<ref>Page 1312. http://books.google.co.in/books?id=TIu28TH_iAYC&printsec=frontcover&source=gbs_ge_summary_r&cad=0#v=onepage&q&f=false</ref> Susceptibility of ''[[Dientamoeba fragilis]]'' has been measured.<ref name="pmid8067755">{{cite journal |author=Chan FT, Guan MX, Mackenzie AM, Diaz-Mitoma F |title=Susceptibility testing of Dientamoeba fragilis ATCC 30948 with iodoquinol, paromomycin, tetracycline, and metronidazole |journal=Antimicrob. Agents Chemother. |volume=38 |issue=5 |pages=1157–60 |year=1994 |month=May |pmid=8067755 |pmc=188168 |doi= |url=http://aac.asm.org/cgi/pmidlookup?view=long&pmid=8067755}}</ref>
+The [[quinoline]] derivative diiodohydroxyquinoline ([[International Nonproprietary Name|INN]]) or iodoquinol ([[United States Adopted Name|USAN]]) can be used in the treatment of ''[[amebiasis]]'', ''[[balantidiasis]]'', and ''[[Dientamoeba fragilis]]''.<ref name="pmid2493578">{{cite journal |author=Ghaskadbi S, Vaidya VG |title=In vivo antimutagenic effect of ascorbic acid against mutagenicity of the common antiamebic drug diiodohydroxyquinoline |journal=Mutat. Res. |volume=222 |issue=3 |pages=219–22 |year=1989 |month=March |pmid=2493578 |doi= 10.1016/0165-1218(89)90137-7|url=}}</ref> It is poorly absorbed from the [[gastrointestinal tract]] and is used as a luminal agent to eradicate both [[cyst]]s and [[trophozoite]]s infestating the lumen of the gastrointestinal tract. Iodoquinol is not recommended for prolonged use due to associated toxicities (eg, [[optic neuritis]], [[optic atrophy]], and [[peripheral neuropathy]]).
 ==Category==
@@ Line 10: / Line 10: @@
 ==US Brand Names==
-ALA-SEPTIC<sup>®</sup>, ALCORTIN<sup>®</sup>, ALCORTIN A<sup>®</sup>, ALOQUIN<sup>®</sup>, DERMAZENE<sup>®</sup>, HYDROCORTISONE IODOQUINOL cream<sup>®</sup>, VYTONE cream<sup>®</sup>
+YODOXIN<sup>®</sup>
-==FDA Package Insert==
+==Package Insert==
 '''[[Iodoquinol description|Description]]'''
-'''| [[Iodoquinol clinical pharmacology|Clinical Pharmacology]]'''
+'''| [[Iodoquinol inactive ingredients|Inactive Ingredients]]'''
-'''| [[Iodoquinol microbiology|Microbiology]]'''
+'''| [[Iodoquinol action|Action]]'''
-'''| [[Iodoquinol indications and usage|Indications and Usage]]'''
+'''| [[Iodoquinol indications|Indications]]'''
 '''| [[Iodoquinol contraindications|Contraindications]]'''
 '''| [[Iodoquinol warnings|Warnings]]'''
+'''| [[Iodoquinol use in pregnancy|Use in Pregnancy]]'''
 '''| [[Iodoquinol precautions|Precautions]]'''
 '''| [[Iodoquinol adverse reactions|Adverse Reactions]]'''
-'''| [[Iodoquinol overdosage|Overdosage]]'''
-'''| [[Iodoquinol clinical studies|Clinical Studies]]'''
 '''| [[Iodoquinol dosage and administration|Dosage and Administration]]'''
-'''| [[Iodoquinol compatibility reconstitution and stability|Compatibility, Reconstitution, and Stability]]'''
-'''| [[Iodoquinol directions for use|Directions For Use]]'''
 '''| [[Iodoquinol how supplied|How Supplied]]'''
-'''| [[Iodoquinol other size packages available|Other Size Packages Available]]'''
+'''| [[Iodoquinol storage|Storage]]'''
-'''| [[Iodoquinol labels and packages|Labels and Packages]]'''
 ==Mechanisms of Action==
-Iodoquinol acts by [[chelation]] of Fe<sup>2+</sup> which is essential for metabolism.<ref>{{cite web|url=http://web.gideononline.com/web/therapy/index.php?type=drugs&code=20130&view=General |work=Gideon Online}}</ref>
+Iodoquinol acts by [[chelation]] of Fe<sup>2+</sup> which is essential for metabolism.
 ==References==