Intravenous leiomyomatosis: Difference between revisions

Jump to navigation Jump to search
No edit summary
No edit summary
Line 8: Line 8:
==Overview==
==Overview==
Intravenous leiomyomatosis is characterized by the extension into venous channels of histologically benign smooth muscle tumor arising from either the wall of a vessel or from a [[uterine leiomyoma]]. The etiology of intravenous leiomyomatosis is unclear. Intravenous leiomyomatosis must be differentiated from other diseases such as [[renal malignancies]] and [[sarcoma]]. The median age is 45 years, with patients ranging from 26 to 70 years old. Only females may develop intravenous leiomyomatosis. Common complications of intravenous leiomyomatosis include [[embolization]], recurrence of the tumor, and metastasis. Surgery is the mainstay of therapy for intravenous leiomyomatosis.
Intravenous leiomyomatosis is characterized by the extension into venous channels of histologically benign smooth muscle tumor arising from either the wall of a vessel or from a [[uterine leiomyoma]]. The etiology of intravenous leiomyomatosis is unclear. Intravenous leiomyomatosis must be differentiated from other diseases such as [[renal malignancies]] and [[sarcoma]]. The median age is 45 years, with patients ranging from 26 to 70 years old. Only females may develop intravenous leiomyomatosis. Common complications of intravenous leiomyomatosis include [[embolization]], recurrence of the tumor, and metastasis. Surgery is the mainstay of therapy for intravenous leiomyomatosis.
==Historical Perspective==
*[Disease name] was first discovered by [scientist name], a [nationality + occupation], in [year] during/following [event].
*In [year], [gene] mutations were first identified in the pathogenesis of [disease name].
*In [year], the first [discovery] was developed by [scientist] to treat/diagnose [disease name].
==Pathophysiology==
==Pathophysiology==
* Intravenous leiomyomatosis is characterized by the extension into venous channels of histologically benign smooth muscle tumor arising from either the wall of a vessel or from a [[uterine leiomyoma]].  
* Intravenous leiomyomatosis is characterized by the extension into venous channels of histologically benign smooth muscle tumor arising from either the wall of a vessel or from a [[uterine leiomyoma]].  
Line 22: Line 27:
*The median age is 45 years, with patients ranging from 26 to 70 years old.
*The median age is 45 years, with patients ranging from 26 to 70 years old.
*Female are exclusively  affected with intravenous leiomyomatosis.
*Female are exclusively  affected with intravenous leiomyomatosis.
== Natural History, Complications and Prognosis==
*Common complications of intravenous leiomyomatosis include embolization, recurrence of the tumor, and metastasis.
*The tumor is slow growing, and the prognosis is favorable.
== Diagnosis ==
=== Symptoms ===
*Patients may be asymptomatic or have symptoms of uterine leiomyomas, [[Syncope|syncopal episodes]], and [[dyspnea]] on exertion.


==Overview==
==Historical Perspective==
*[Disease name] was first discovered by [scientist name], a [nationality + occupation], in [year] during/following [event].
*In [year], [gene] mutations were first identified in the pathogenesis of [disease name].
*In [year], the first [discovery] was developed by [scientist] to treat/diagnose [disease name].
==Classification==
*[Disease name] may be classified according to [classification method] into [number] subtypes/groups:
:*[group1]
:*[group2]
:*[group3]
*Other variants of [disease name] include [disease subtype 1], [disease subtype 2], and [disease subtype 3].
==Pathophysiology==
*The pathogenesis of [disease name] is characterized by [feature1], [feature2], and [feature3].
*The [gene name] gene/Mutation in [gene name] has been associated with the development of [disease name], involving the [molecular pathway] pathway.
*On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
*On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
==Clinical Features== 
==Differentiating [disease name] from other Diseases==
*[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as:
:*[Differential dx1]
:*[Differential dx2]
:*[Differential dx3]
==Epidemiology and Demographics==
* The prevalence of [disease name] is approximately [number or range] per 100,000 individuals worldwide.
* The prevalence of [disease name] is approximately [number or range] per 100,000 individuals worldwide.
* In [year], the incidence of [disease name] was estimated to be [number or range] cases per 100,000 individuals in [location].
* In [year], the incidence of [disease name] was estimated to be [number or range] cases per 100,000 individuals in [location].
Line 89: Line 58:
*Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
*Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
*Prognosis is generally [excellent/good/poor], and the [1/5/10­year mortality/survival rate] of patients with [disease name] is approximately [#%].
*Prognosis is generally [excellent/good/poor], and the [1/5/10­year mortality/survival rate] of patients with [disease name] is approximately [#%].
*Common complications of intravenous leiomyomatosis include embolization, recurrence of the tumor, and metastasis.
*The tumor is slow growing, and the prognosis is favorable.
*


== Diagnosis ==
== Diagnosis ==
Line 99: Line 72:
   
   
=== Symptoms ===
=== Symptoms ===
Patients may be asymptomatic or have symptoms of uterine leiomyomas, [[Syncope|syncopal episodes]], and [[dyspnea]] on exertion.
*[Disease name] is usually asymptomatic.
*[Disease name] is usually asymptomatic.
*Symptoms of [disease name] may include the following:
*Symptoms of [disease name] may include the following:

Revision as of 23:48, 4 April 2019

WikiDoc Resources for Intravenous leiomyomatosis

Articles

Most recent articles on Intravenous leiomyomatosis

Most cited articles on Intravenous leiomyomatosis

Review articles on Intravenous leiomyomatosis

Articles on Intravenous leiomyomatosis in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Intravenous leiomyomatosis

Images of Intravenous leiomyomatosis

Photos of Intravenous leiomyomatosis

Podcasts & MP3s on Intravenous leiomyomatosis

Videos on Intravenous leiomyomatosis

Evidence Based Medicine

Cochrane Collaboration on Intravenous leiomyomatosis

Bandolier on Intravenous leiomyomatosis

TRIP on Intravenous leiomyomatosis

Clinical Trials

Ongoing Trials on Intravenous leiomyomatosis at Clinical Trials.gov

Trial results on Intravenous leiomyomatosis

Clinical Trials on Intravenous leiomyomatosis at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Intravenous leiomyomatosis

NICE Guidance on Intravenous leiomyomatosis

NHS PRODIGY Guidance

FDA on Intravenous leiomyomatosis

CDC on Intravenous leiomyomatosis

Books

Books on Intravenous leiomyomatosis

News

Intravenous leiomyomatosis in the news

Be alerted to news on Intravenous leiomyomatosis

News trends on Intravenous leiomyomatosis

Commentary

Blogs on Intravenous leiomyomatosis

Definitions

Definitions of Intravenous leiomyomatosis

Patient Resources / Community

Patient resources on Intravenous leiomyomatosis

Discussion groups on Intravenous leiomyomatosis

Patient Handouts on Intravenous leiomyomatosis

Directions to Hospitals Treating Intravenous leiomyomatosis

Risk calculators and risk factors for Intravenous leiomyomatosis

Healthcare Provider Resources

Symptoms of Intravenous leiomyomatosis

Causes & Risk Factors for Intravenous leiomyomatosis

Diagnostic studies for Intravenous leiomyomatosis

Treatment of Intravenous leiomyomatosis

Continuing Medical Education (CME)

CME Programs on Intravenous leiomyomatosis

International

Intravenous leiomyomatosis en Espanol

Intravenous leiomyomatosis en Francais

Business

Intravenous leiomyomatosis in the Marketplace

Patents on Intravenous leiomyomatosis

Experimental / Informatics

List of terms related to Intravenous leiomyomatosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]; Ammu Susheela, M.D. [3]

Synonyms and keywords: Nesidioblastoma, IVLM

Overview

Intravenous leiomyomatosis is characterized by the extension into venous channels of histologically benign smooth muscle tumor arising from either the wall of a vessel or from a uterine leiomyoma. The etiology of intravenous leiomyomatosis is unclear. Intravenous leiomyomatosis must be differentiated from other diseases such as renal malignancies and sarcoma. The median age is 45 years, with patients ranging from 26 to 70 years old. Only females may develop intravenous leiomyomatosis. Common complications of intravenous leiomyomatosis include embolization, recurrence of the tumor, and metastasis. Surgery is the mainstay of therapy for intravenous leiomyomatosis.

Historical Perspective

  • [Disease name] was first discovered by [scientist name], a [nationality + occupation], in [year] during/following [event].
  • In [year], [gene] mutations were first identified in the pathogenesis of [disease name].
  • In [year], the first [discovery] was developed by [scientist] to treat/diagnose [disease name].

Pathophysiology

  • Intravenous leiomyomatosis is characterized by the extension into venous channels of histologically benign smooth muscle tumor arising from either the wall of a vessel or from a uterine leiomyoma.
  • Patients are exclusively female, and the majority are white, premenopausal, and parous.
  • Intravenous leiomyomatosis should be considered in young women with cardiac symptoms who have a right atrial mass as well as a pelvic mass or who have previously undergone hysterectomy for leiomyoma uterus with intravenous involvement.

Causes

  • The etiology of intravenous leiomyomatosis is unclear.

Differentiating Intravenous Leiomyomatosis from other Diseases

  • Intravenous leiomyomatosis must be differentiated from other diseases such as:
  • Renal malignancies
  • Sarcoma
  • Thrombosis of the intravenous catheter

Epidemiology and Demographics

  • The median age is 45 years, with patients ranging from 26 to 70 years old.
  • Female are exclusively affected with intravenous leiomyomatosis.
  • The prevalence of [disease name] is approximately [number or range] per 100,000 individuals worldwide.
  • In [year], the incidence of [disease name] was estimated to be [number or range] cases per 100,000 individuals in [location].

Age

  • Patients of all age groups may develop [disease name].
  • [Disease name] is more commonly observed among patients aged [age range] years old.
  • [Disease name] is more commonly observed among [elderly patients/young patients/children].

Gender

  • [Disease name] affects men and women equally.
  • [Gender 1] are more commonly affected with [disease name] than [gender 2].
  • The [gender 1] to [Gender 2] ratio is approximately [number > 1] to 1.

Race

  • There is no racial predilection for [disease name].
  • [Disease name] usually affects individuals of the [race 1] race.
  • [Race 2] individuals are less likely to develop [disease name].

Risk Factors

  • Common risk factors in the development of [disease name] are [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].

Natural History, Complications and Prognosis

  • The majority of patients with [disease name] remain asymptomatic for [duration/years].
  • Early clinical features include [manifestation 1], [manifestation 2], and [manifestation 3].
  • If left untreated, [#%] of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
  • Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
  • Prognosis is generally [excellent/good/poor], and the [1/5/10­year mortality/survival rate] of patients with [disease name] is approximately [#%].
  • Common complications of intravenous leiomyomatosis include embolization, recurrence of the tumor, and metastasis.
  • The tumor is slow growing, and the prognosis is favorable.

Diagnosis

Diagnostic Criteria

  • The diagnosis of [disease name] is made when at least [number] of the following [number] diagnostic criteria are met:
  • [criterion 1]
  • [criterion 2]
  • [criterion 3]
  • [criterion 4]

Symptoms

Patients may be asymptomatic or have symptoms of uterine leiomyomas, syncopal episodes, and dyspnea on exertion.

  • [Disease name] is usually asymptomatic.
  • Symptoms of [disease name] may include the following:
  • [symptom 1]
  • [symptom 2]
  • [symptom 3]
  • [symptom 4]
  • [symptom 5]
  • [symptom 6]

Physical Examination

  • Patients with [disease name] usually appear [general appearance].
  • Physical examination may be remarkable for:
  • [finding 1]
  • [finding 2]
  • [finding 3]
  • [finding 4]
  • [finding 5]
  • [finding 6]

Laboratory Findings

  • There are no specific laboratory findings associated with [disease name].
  • A [positive/negative] [test name] is diagnostic of [disease name].
  • An [elevated/reduced] concentration of [serum/blood/urinary/CSF/other] [lab test] is diagnostic of [disease name].
  • Other laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].

Imaging Findings

  • There are no [imaging study] findings associated with [disease name].
  • [Imaging study 1] is the imaging modality of choice for [disease name].
  • On [imaging study 1], [disease name] is characterized by [finding 1], [finding 2], and [finding 3].
  • [Imaging study 2] may demonstrate [finding 1], [finding 2], and [finding 3].

Other Diagnostic Studies

  • [Disease name] may also be diagnosed using [diagnostic study name].
  • Findings on [diagnostic study name] include [finding 1], [finding 2], and [finding 3].

Treatment

Medical Therapy

  • There is no treatment for [disease name]; the mainstay of therapy is supportive care.
  • The mainstay of therapy for [disease name] is [medical therapy 1] and [medical therapy 2].
  • [Medical therapy 1] acts by [mechanism of action 1].
  • Response to [medical therapy 1] can be monitored with [test/physical finding/imaging] every [frequency/duration].

Surgery

  • Surgery is the mainstay of therapy for [disease name].
  • [Surgical procedure] in conjunction with [chemotherapy/radiation] is the most common approach to the treatment of [disease name].
  • [Surgical procedure] can only be performed for patients with [disease stage] [disease name].

Prevention

  • There are no primary preventive measures available for [disease name].
  • Effective measures for the primary prevention of [disease name] include [measure1], [measure2], and [measure3].
  • Once diagnosed and successfully treated, patients with [disease name] are followed-up every [duration]. Follow-up testing includes [test 1], [test 2], and [test 3].

References

Template:WS Template:WH


Images

Example #1

The patient presented with S.O.B. one year after hysterectomy for a leiomyomatous uterus.

Treatment

  • Surgery is the mainstay of therapy for intravenous leiomyomatosis.

Related Chapters

References


Template:WikiDoc Sources