Interferon Beta-1A
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];
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Overview
Interferon Beta-1A is an immunologic adjuvant that is FDA approved for the treatment of multiple sclerosis. Common adverse reactions include flu-like symptoms including chills, fever, myalgia, and asthenia.
Adult Indications and Dosage
FDA-Labeled Indications and Dosage (Adult)
Multiple Sclerosis, Relapsing forms
AVONEX (interferon beta-1a) is indicated for the treatment of patients with relapsing forms of multiple sclerosis to slow the accumulation of physical disability and decrease the frequency of clinical exacerbations. Patients with multiple sclerosis in whom efficacy has been demonstrated include patients who have experienced a first clinical episode and have MRI features consistent with multiple sclerosis.
Off-Label Use and Dosage (Adult)
Guideline-Supported Use
There is limited information regarding Off-Label Guideline-Supported Use of Interferon Beta-1A in adult patients.
Non–Guideline-Supported Use
Multiple sclerosis, Clinically Isolated Syndrome
Efficacy has been demonstrated in patients who have experienced a first clinical episode and have MRI features consistent with multiple sclerosis.
Pediatric Indications and Dosage
FDA-Labeled Indications and Dosage (Pediatric)
Safety and effectiveness in pediatric patients have not been established.
Off-Label Use and Dosage (Pediatric)
Guideline-Supported Use
There is limited information regarding Off-Label Guideline-Supported Use of Interferon Beta-1A in pediatric patients.
Non–Guideline-Supported Use
There is limited information regarding Off-Label Non–Guideline-Supported Use of Interferon Beta-1A in pediatric patients.
Contraindications
There is limited information regarding Interferon Beta-1A Contraindications in the drug label.
Warnings
There is limited information regarding Interferon Beta-1A Warnings' in the drug label.
Adverse Reactions
Clinical Trials Experience
There is limited information regarding Interferon Beta-1A Clinical Trials Experience in the drug label.
Postmarketing Experience
There is limited information regarding Interferon Beta-1A Postmarketing Experience in the drug label.
Drug Interactions
There is limited information regarding Interferon Beta-1A Drug Interactions in the drug label.
Use in Specific Populations
Pregnancy
Pregnancy Category (FDA):
There is no FDA guidance on usage of Interferon Beta-1A in women who are pregnant.
Pregnancy Category (AUS):
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Interferon Beta-1A in women who are pregnant.
Labor and Delivery
There is no FDA guidance on use of Interferon Beta-1A during labor and delivery.
Nursing Mothers
There is no FDA guidance on the use of Interferon Beta-1A in women who are nursing.
Pediatric Use
There is no FDA guidance on the use of Interferon Beta-1A in pediatric settings.
Geriatic Use
There is no FDA guidance on the use of Interferon Beta-1A in geriatric settings.
Gender
There is no FDA guidance on the use of Interferon Beta-1A with respect to specific gender populations.
Race
There is no FDA guidance on the use of Interferon Beta-1A with respect to specific racial populations.
Renal Impairment
There is no FDA guidance on the use of Interferon Beta-1A in patients with renal impairment.
Hepatic Impairment
There is no FDA guidance on the use of Interferon Beta-1A in patients with hepatic impairment.
Females of Reproductive Potential and Males
There is no FDA guidance on the use of Interferon Beta-1A in women of reproductive potentials and males.
Immunocompromised Patients
There is no FDA guidance one the use of Interferon Beta-1A in patients who are immunocompromised.
Administration and Monitoring
Administration
There is limited information regarding Interferon Beta-1A Administration in the drug label.
Monitoring
There is limited information regarding Interferon Beta-1A Monitoring in the drug label.
IV Compatibility
There is limited information regarding the compatibility of Interferon Beta-1A and IV administrations.
Overdosage
There is limited information regarding Interferon Beta-1A overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.
Pharmacology
There is limited information regarding Interferon Beta-1A Pharmacology in the drug label.
Mechanism of Action
There is limited information regarding Interferon Beta-1A Mechanism of Action in the drug label.
Structure
There is limited information regarding Interferon Beta-1A Structure in the drug label.
Pharmacodynamics
There is limited information regarding Interferon Beta-1A Pharmacodynamics in the drug label.
Pharmacokinetics
There is limited information regarding Interferon Beta-1A Pharmacokinetics in the drug label.
Nonclinical Toxicology
There is limited information regarding Interferon Beta-1A Nonclinical Toxicology in the drug label.
Clinical Studies
There is limited information regarding Interferon Beta-1A Clinical Studies in the drug label.
How Supplied
There is limited information regarding Interferon Beta-1A How Supplied in the drug label.
Storage
There is limited information regarding Interferon Beta-1A Storage in the drug label.
Images
Drug Images
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Package and Label Display Panel
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Patient Counseling Information
There is limited information regarding Interferon Beta-1A Patient Counseling Information in the drug label.
Precautions with Alcohol
Alcohol-Interferon Beta-1A interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
Brand Names
There is limited information regarding Interferon Beta-1A Brand Names in the drug label.
Look-Alike Drug Names
There is limited information regarding Interferon Beta-1A Look-Alike Drug Names in the drug label.
Drug Shortage Status
Price
References
The contents of this FDA label are provided by the National Library of Medicine.