Integrin, beta 6: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Integrin beta-6''' is a [[protein]] that in humans is encoded by the ''ITGB6'' [[gene]].<ref name="pmid1729173">{{cite journal |vauthors=Krissansen GW, Yuan Q, Jenkins D, Jiang WM, Rooke L, Spurr NK, Eccles M, Leung E, Watson JD | title = Chromosomal locations of the genes coding for the integrin beta 6 and beta 7 subunits | journal = Immunogenetics | volume = 35 | issue = 1 | pages = 58–61 |date=February 1992 | pmid = 1729173 | pmc =  | doi =  10.1007/bf00216629}}</ref><ref name="pmid8120056">{{cite journal |vauthors=Weinacker A, Chen A, Agrez M, Cone RI, Nishimura S, Wayner E, Pytela R, Sheppard D | title = Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor | journal = J Biol Chem | volume = 269 | issue = 9 | pages = 6940–8 |date=April 1994 | pmid = 8120056 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ITGB6 integrin, beta 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3694| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Integrin, beta 6
| HGNCid = 6161
| Symbol = ITGB6
| AltSymbols =;
| OMIM = 147558
| ECnumber =
| Homologene = 685
| MGIid = 96615
  | GeneAtlas_image1 = PBB_GE_ITGB6_208083_s_at_tn.png
  | GeneAtlas_image2 = PBB_GE_ITGB6_208084_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005178 |text = integrin binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0008305 |text = integrin complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007160 |text = cell-matrix adhesion}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3694
    | Hs_Ensembl = ENSG00000115221
    | Hs_RefseqProtein = NP_000879
    | Hs_RefseqmRNA = NM_000888
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 160664438
    | Hs_GenLoc_end = 160765009
    | Hs_Uniprot = P18564
    | Mm_EntrezGene = 16420
    | Mm_Ensembl = ENSMUSG00000026971
    | Mm_RefseqmRNA = NM_021359
    | Mm_RefseqProtein = NP_067334
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 60399131
    | Mm_GenLoc_end = 60523442
    | Mm_Uniprot = Q9Z0T9
  }}
}}
'''Integrin, beta 6''', also known as '''ITGB6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ITGB6 integrin, beta 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3694| accessdate = }}</ref>


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| summary_text =  
| summary_text =  
}}
}}
==Clinical effects==
Mutations in [[ITGB6]] cause {{SWL|type=mutation_results_in|target=amelogenesis imperfecta|label=amelogenesis imperfecta}}.<ref>{{Cite journal
| pmid = 24305999
| year = 2014
| author1 = Wang
| first1 = S. K.
| title = ITGB6 loss-of-function mutations cause autosomal recessive amelogenesis imperfecta
| journal = Human Molecular Genetics
| volume = 23
| issue = 8
| pages = 2157–63
| last2 = Choi
| first2 = M
| last3 = Richardson
| first3 = A. S.
| last4 = Reid
| first4 = B. M.
| last5 = Lin
| first5 = B. P.
| last6 = Wang
| first6 = S. J.
| last7 = Kim
| first7 = J. W.
| last8 = Simmer
| first8 = J. P.
| last9 = Hu
| first9 = J. C.
| doi = 10.1093/hmg/ddt611
| pmc = 3959820
}}</ref>
==Interactions==
Integrin, beta 6 has been shown to [[Protein-protein interaction|interact]] with [[FHL2]].<ref name=pmid10906324>{{cite journal |last=Wixler |first=V |authorlink= |author2=Geerts D |author3=Laplantine E |author4=Westhoff D |author5=Smyth N |author6=Aumailley M |author7=Sonnenberg A |author8=Paulsson M  |date=October 2000  |title=The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes |journal=J. Biol. Chem. |volume=275 |issue=43 |pages=33669–78 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10906324 |doi = 10.1074/jbc.M002519200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Bowen JA, Hunt JS |title=The role of integrins in reproduction. |journal=Proc. Soc. Exp. Biol. Med. |volume=223 |issue= 4 |pages= 331-43 |year= 2000 |pmid= 10721002 |doi=  }}
*{{cite journal  |vauthors=Bowen JA, Hunt JS |title=The role of integrins in reproduction. |journal=Proc. Soc. Exp. Biol. Med. |volume=223 |issue= 4 |pages= 331–43 |year= 2000 |pmid= 10721002 |doi=10.1046/j.1525-1373.2000.22348.x }}
*{{cite journal | author=Jiang WM, Jenkins D, Yuan Q, ''et al.'' |title=The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1. |journal=Int. Immunol. |volume=4 |issue= 9 |pages= 1031-40 |year= 1992 |pmid= 1382574 |doi=  }}
*{{cite journal   |vauthors=Jiang WM, Jenkins D, Yuan Q, etal |title=The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1. |journal=Int. Immunol. |volume=4 |issue= 9 |pages= 1031–40 |year= 1992 |pmid= 1382574 |doi=10.1093/intimm/4.9.1031 }}
*{{cite journal  | author=Busk M, Pytela R, Sheppard D |title=Characterization of the integrin alpha v beta 6 as a fibronectin-binding protein. |journal=J. Biol. Chem. |volume=267 |issue= 9 |pages= 5790-6 |year= 1992 |pmid= 1532572 |doi=  }}
*{{cite journal  |vauthors=Busk M, Pytela R, Sheppard D |title=Characterization of the integrin alpha v beta 6 as a fibronectin-binding protein. |journal=J. Biol. Chem. |volume=267 |issue= 9 |pages= 5790–6 |year= 1992 |pmid= 1532572 |doi=  }}
*{{cite journal | author=Krissansen GW, Yuan Q, Jenkins D, ''et al.'' |title=Chromosomal locations of the genes coding for the integrin beta 6 and beta 7 subunits. |journal=Immunogenetics |volume=35 |issue= 1 |pages= 58-61 |year= 1992 |pmid= 1729173 |doi=  }}
*{{cite journal   |vauthors=Sheppard D, Rozzo C, Starr L, etal |title=Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction. |journal=J. Biol. Chem. |volume=265 |issue= 20 |pages= 11502–7 |year= 1990 |pmid= 2365683 |doi=  }}
*{{cite journal  | author=Sheppard D, Rozzo C, Starr L, ''et al.'' |title=Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction. |journal=J. Biol. Chem. |volume=265 |issue= 20 |pages= 11502-7 |year= 1990 |pmid= 2365683 |doi=  }}
*{{cite journal   |vauthors=Weinacker A, Ferrando R, Elliott M, etal |title=Distribution of integrins alpha v beta 6 and alpha 9 beta 1 and their known ligands, fibronectin and tenascin, in human airways. |journal=Am. J. Respir. Cell Mol. Biol. |volume=12 |issue= 5 |pages= 547–56 |year= 1995 |pmid= 7537970 |doi=  10.1165/ajrcmb.12.5.7537970}}
*{{cite journal | author=Weinacker A, Ferrando R, Elliott M, ''et al.'' |title=Distribution of integrins alpha v beta 6 and alpha 9 beta 1 and their known ligands, fibronectin and tenascin, in human airways. |journal=Am. J. Respir. Cell Mol. Biol. |volume=12 |issue= 5 |pages= 547-56 |year= 1995 |pmid= 7537970 |doi=  }}
*{{cite journal  |vauthors=Huang XZ, Chen A, Agrez M, Sheppard D |title=A point mutation in the integrin beta 6 subunit abolishes both alpha v beta 6 binding to fibronectin and receptor localization to focal contacts. |journal=Am. J. Respir. Cell Mol. Biol. |volume=13 |issue= 2 |pages= 245–51 |year= 1995 |pmid= 7626292 |doi=  10.1165/ajrcmb.13.2.7626292}}
*{{cite journal  | author=Huang XZ, Chen A, Agrez M, Sheppard D |title=A point mutation in the integrin beta 6 subunit abolishes both alpha v beta 6 binding to fibronectin and receptor localization to focal contacts. |journal=Am. J. Respir. Cell Mol. Biol. |volume=13 |issue= 2 |pages= 245-51 |year= 1995 |pmid= 7626292 |doi=  }}
*{{cite journal  |vauthors=Fernández-Ruiz E, Sánchez-Madrid F |title=Regional localization of the human integrin beta 6 gene (ITGB6) to chromosome 2q24-q31. |journal=Genomics |volume=21 |issue= 3 |pages= 638–40 |year= 1994 |pmid= 7959743 |doi= 10.1006/geno.1994.1325 }}
*{{cite journal  | author=Fernández-Ruiz E, Sánchez-Madrid F |title=Regional localization of the human integrin beta 6 gene (ITGB6) to chromosome 2q24-q31. |journal=Genomics |volume=21 |issue= 3 |pages= 638-40 |year= 1994 |pmid= 7959743 |doi= 10.1006/geno.1994.1325 }}
*{{cite journal  |vauthors=Cone RI, Weinacker A, Chen A, Sheppard D |title=Effects of beta subunit cytoplasmic domain deletions on the recruitment of the integrin alpha v beta 6 to focal contacts. |journal=Cell Adhes. Commun. |volume=2 |issue= 2 |pages= 101–13 |year= 1994 |pmid= 8081887 |doi=10.3109/15419069409004430 }}
*{{cite journal  | author=Cone RI, Weinacker A, Chen A, Sheppard D |title=Effects of beta subunit cytoplasmic domain deletions on the recruitment of the integrin alpha v beta 6 to focal contacts. |journal=Cell Adhes. Commun. |volume=2 |issue= 2 |pages= 101-13 |year= 1994 |pmid= 8081887 |doi= }}
*{{cite journal  |vauthors=Yokosaki Y, Monis H, Chen J, Sheppard D |title=Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains. |journal=J. Biol. Chem. |volume=271 |issue= 39 |pages= 24144–50 |year= 1996 |pmid= 8798654 |doi=10.1074/jbc.271.39.24144 }}
*{{cite journal  | author=Weinacker A, Chen A, Agrez M, ''et al.'' |title=Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor. |journal=J. Biol. Chem. |volume=269 |issue= 9 |pages= 6940-8 |year= 1994 |pmid= 8120056 |doi= }}
*{{cite journal  |vauthors=Pilewski JM, Latoche JD, Arcasoy SM, Albelda SM |title=Expression of integrin cell adhesion receptors during human airway epithelial repair in vivo. |journal=Am. J. Physiol. |volume=273 |issue= 1 Pt 1 |pages= L256–63 |year= 1997 |pmid= 9252563 |doi=  }}
*{{cite journal  | author=Yokosaki Y, Monis H, Chen J, Sheppard D |title=Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains. |journal=J. Biol. Chem. |volume=271 |issue= 39 |pages= 24144-50 |year= 1996 |pmid= 8798654 |doi=  }}
*{{cite journal   |vauthors=Ostergaard K, Salter DM, Petersen J, etal |title=Expression of alpha and beta subunits of the integrin superfamily in articular cartilage from macroscopically normal and osteoarthritic human femoral heads. |journal=Ann. Rheum. Dis. |volume=57 |issue= 5 |pages= 303–8 |year= 1998 |pmid= 9741315 |doi=10.1136/ard.57.5.303  | pmc=1752603 }}
*{{cite journal  | author=Pilewski JM, Latoche JD, Arcasoy SM, Albelda SM |title=Expression of integrin cell adhesion receptors during human airway epithelial repair in vivo. |journal=Am. J. Physiol. |volume=273 |issue= 1 Pt 1 |pages= L256-63 |year= 1997 |pmid= 9252563 |doi=  }}
*{{cite journal   |vauthors=Munger JS, Huang X, Kawakatsu H, etal |title=The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. |journal=Cell |volume=96 |issue= 3 |pages= 319–28 |year= 1999 |pmid= 10025398 |doi=10.1016/S0092-8674(00)80545-0 }}
*{{cite journal | author=Ostergaard K, Salter DM, Petersen J, ''et al.'' |title=Expression of alpha and beta subunits of the integrin superfamily in articular cartilage from macroscopically normal and osteoarthritic human femoral heads. |journal=Ann. Rheum. Dis. |volume=57 |issue= 5 |pages= 303-8 |year= 1998 |pmid= 9741315 |doi=  }}
*{{cite journal   |vauthors=Wixler V, Geerts D, Laplantine E, etal |title=The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes. |journal=J. Biol. Chem. |volume=275 |issue= 43 |pages= 33669–78 |year= 2000 |pmid= 10906324 |doi= 10.1074/jbc.M002519200 }}
*{{cite journal | author=Munger JS, Huang X, Kawakatsu H, ''et al.'' |title=The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. |journal=Cell |volume=96 |issue= 3 |pages= 319-28 |year= 1999 |pmid= 10025398 |doi=  }}
*{{cite journal   |vauthors=Arihiro K, Kaneko M, Fujii S, etal |title=Significance of alpha 9 beta 1 and alpha v beta 6 integrin expression in breast carcinoma. |journal=Breast Cancer |volume=7 |issue= 1 |pages= 19–26 |year= 2000 |pmid= 11029766 |doi=  10.1007/bf02967183}}
*{{cite journal | author=Wixler V, Geerts D, Laplantine E, ''et al.'' |title=The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes. |journal=J. Biol. Chem. |volume=275 |issue= 43 |pages= 33669-78 |year= 2000 |pmid= 10906324 |doi= 10.1074/jbc.M002519200 }}
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal | author=Arihiro K, Kaneko M, Fujii S, ''et al.'' |title=Significance of alpha 9 beta 1 and alpha v beta 6 integrin expression in breast carcinoma. |journal=Breast Cancer |volume=7 |issue= 1 |pages= 19-26 |year= 2000 |pmid= 11029766 |doi=  }}
*{{cite journal  |vauthors=Arend LJ, Smart AM, Briggs JP |title=Mouse beta(6) integrin sequence, pattern of expression, and role in kidney development. |journal=J. Am. Soc. Nephrol. |volume=11 |issue= 12 |pages= 2297–305 |year= 2001 |pmid= 11095652 |doi=  }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal   |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072 }}
*{{cite journal  | author=Arend LJ, Smart AM, Briggs JP |title=Mouse beta(6) integrin sequence, pattern of expression, and role in kidney development. |journal=J. Am. Soc. Nephrol. |volume=11 |issue= 12 |pages= 2297-305 |year= 2001 |pmid= 11095652 |doi=  }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* [https://www.ncbi.nlm.nih.gov/books/NBK1157/  GeneReviews/NCBI/NIH/UW entry on Epidermolysis Bullosa with Pyloric Atresia]
*[http://cmkb.cellmigration.org/report.cgi?report=orth_overview&orth_acc=co00001712 ITGB6] Info with links in the [http://www.cellmigration.org/index.shtml Cell Migration Gateway]
 
{{Integrins}}
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[[Category:Integrins]]
 
 
{{gene-2-stub}}

Latest revision as of 05:12, 1 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Integrin beta-6 is a protein that in humans is encoded by the ITGB6 gene.[1][2][3]


Clinical effects

Mutations in ITGB6 cause amelogenesis imperfecta .[4]

Interactions

Integrin, beta 6 has been shown to interact with FHL2.[5]

References

  1. ↑ Krissansen GW, Yuan Q, Jenkins D, Jiang WM, Rooke L, Spurr NK, Eccles M, Leung E, Watson JD (February 1992). "Chromosomal locations of the genes coding for the integrin beta 6 and beta 7 subunits". Immunogenetics. 35 (1): 58–61. doi:10.1007/bf00216629. PMID 1729173.
  2. ↑ Weinacker A, Chen A, Agrez M, Cone RI, Nishimura S, Wayner E, Pytela R, Sheppard D (April 1994). "Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor". J Biol Chem. 269 (9): 6940–8. PMID 8120056.
  3. ↑ "Entrez Gene: ITGB6 integrin, beta 6".
  4. ↑ Wang, S. K.; Choi, M; Richardson, A. S.; Reid, B. M.; Lin, B. P.; Wang, S. J.; Kim, J. W.; Simmer, J. P.; Hu, J. C. (2014). "ITGB6 loss-of-function mutations cause autosomal recessive amelogenesis imperfecta". Human Molecular Genetics. 23 (8): 2157–63. doi:10.1093/hmg/ddt611. PMC 3959820. PMID 24305999.
  5. ↑ Wixler, V; Geerts D; Laplantine E; Westhoff D; Smyth N; Aumailley M; Sonnenberg A; Paulsson M (October 2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes". J. Biol. Chem. UNITED STATES. 275 (43): 33669–78. doi:10.1074/jbc.M002519200. ISSN 0021-9258. PMID 10906324.

Further reading

External links


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