Insulinoma surgery

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]

Overview

Surgery is the mainstay of treatment for insulinoma. The feasibility of surgery depends on the stage of insulinoma at diagnosis.[1][2]

Surgery

Surgery is the mainstay of treatment for insulinoma. The feasibility of surgery depends on the stage of insulinoma at diagnosis.

Benign Tumors

  • Small well-encapsulated, solitary tumors:[1][2]
  • Surgical resection is treatment of choice (minimal invasive surgery)
  • Enucleation
  • Partial pancreatectomy
  • Middle pancreatectomy
  • Multiple, unencapsulated, >4 cm in diameter, and involves or is near the main pancreatic duct:
  • Radical resection

Malignant Tumors

  • Aggressive surgical resection, including extended pancreatic resection, liver resection, and/or liver transplantation
  • Post-surgical chemoembolization or radiofrequency ablation of tumors to control hypoglycemia
  • Unresectable tumors

References

  1. 1.0 1.1 1.2 Okabayashi T, Shima Y, Sumiyoshi T, Kozuki A, Ito S, Ogawa Y; et al. (2013). "Diagnosis and management of insulinoma". World J Gastroenterol. 19 (6): 829–37. doi:10.3748/wjg.v19.i6.829. PMC 3574879. PMID 23430217.
  2. 2.0 2.1 2.2 Inulinoma. national library of medicine. https://www.nlm.nih.gov/medlineplus/ency/article/000387.htm