Insulinoma epidemiology and demographics: Difference between revisions

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{{Insulinoma}}
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==Overview==
==Overview==
The [[incidence]] of insulinoma is approximately 0.1-0.4 per 100,000 individuals that constitute 1-2% of all [[Pancreatic neoplasm|pancreatic neoplasms]]. The female to male ratio is approximately 3:2. There is no regional predisposition.


==Epidemiology and Demographics==
==Epidemiology and Demographics==
===Incidence===
===Incidence===
*Insulinomas are rare [[neuroendocrine tumor]]s with an incidence estimated at 1 to 4 new cases per million persons per year.
*The [[incidence]] of insulinoma is approximately 0.1-0.4 per 100,000 individuals that constitute 1-2% of all [[Pancreatic neoplasm|pancreatic neoplasms]].<ref name="pmid23430217">{{cite journal |vauthors=Okabayashi T, Shima Y, Sumiyoshi T, Kozuki A, Ito S, Ogawa Y, Kobayashi M, Hanazaki K |title=Diagnosis and management of insulinoma |journal=World J. Gastroenterol. |volume=19 |issue=6 |pages=829–37 |year=2013 |pmid=23430217 |pmc=3574879 |doi=10.3748/wjg.v19.i6.829 |url=}}</ref><ref name="pmid1677058">{{cite journal |vauthors=Service FJ, McMahon MM, O'Brien PC, Ballard DJ |title=Functioning insulinoma--incidence, recurrence, and long-term survival of patients: a 60-year study |journal=Mayo Clin. Proc. |volume=66 |issue=7 |pages=711–9 |year=1991 |pmid=1677058 |doi= |url=}}</ref>
*Insulinoma is one of the most common types of tumor arising from the [[islets of Langerhans]] cells (pancreatic endocrine tumors).  
*Estimates of malignancy (metastases) range from 5% to 30%.  
*Over 99% of insulinomas originate in the pancreas, with rare cases from ectopic pancreatic tissue.
*About 5% of cases are associated with tumors of the parathyroid glands and the pituitary ([[Multiple endocrine neoplasia type 1]]) and are more likely to be multiple and malignant.
*Most insulinomas are small, less than 2 cm.
===Age===
===Age===
*The median age at diagnosis is 47 years.
*Patients of all age groups may develop insulinoma.
*Insulinoma commonly affects individuals 40-60 years of age.
 
===Race===
*There is no racial predilection to insulinoma.
===Gender===
===Gender===
* Females (60-75%) are more commonly affected by insulinoma than males. The female to male ratio is approximately 3:2.<ref name="pmid1677058">{{cite journal |vauthors=Service FJ, McMahon MM, O'Brien PC, Ballard DJ |title=Functioning insulinoma--incidence, recurrence, and long-term survival of patients: a 60-year study |journal=Mayo Clin. Proc. |volume=66 |issue=7 |pages=711–9 |year=1991 |pmid=1677058 |doi= |url=}}</ref>


*Females are more commonly affected with insulinoma than males.
===Region===
*The male to female ratio is approximately 2 to 3.
*There is no regional predisposition but it was described according to local studies. One of the best studies ever conducted for insulinoma, by Mayo clinic, showed the [[incidence]] of insulinoma in residents of Olmsted County, Minnesota over the time frame of 60 years.
===Race===
*There is no racial predilection to the insulinoma.


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
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Latest revision as of 02:06, 27 November 2017

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]

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Overview

The incidence of insulinoma is approximately 0.1-0.4 per 100,000 individuals that constitute 1-2% of all pancreatic neoplasms. The female to male ratio is approximately 3:2. There is no regional predisposition.

Epidemiology and Demographics

Incidence

Age

  • Patients of all age groups may develop insulinoma.
  • Insulinoma commonly affects individuals 40-60 years of age.

Race

  • There is no racial predilection to insulinoma.

Gender

  • Females (60-75%) are more commonly affected by insulinoma than males. The female to male ratio is approximately 3:2.[2]

Region

  • There is no regional predisposition but it was described according to local studies. One of the best studies ever conducted for insulinoma, by Mayo clinic, showed the incidence of insulinoma in residents of Olmsted County, Minnesota over the time frame of 60 years.

References

  1. Okabayashi T, Shima Y, Sumiyoshi T, Kozuki A, Ito S, Ogawa Y, Kobayashi M, Hanazaki K (2013). "Diagnosis and management of insulinoma". World J. Gastroenterol. 19 (6): 829–37. doi:10.3748/wjg.v19.i6.829. PMC 3574879. PMID 23430217.
  2. 2.0 2.1 Service FJ, McMahon MM, O'Brien PC, Ballard DJ (1991). "Functioning insulinoma--incidence, recurrence, and long-term survival of patients: a 60-year study". Mayo Clin. Proc. 66 (7): 711–9. PMID 1677058.

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