Insulinoma (patient information): Difference between revisions

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{{Template:Insulinoma (patient information)}}
'''For the WikiDoc page for this topic, click [[Insulinoma|here]]'''
'''For the WikiDoc page for this topic, click [[Insulinoma|here]]'''


{{Infobox_Disease |
  Name          = {{PAGENAME}} |
  DiseasesDB    = 6830 |
  ICD10          = {{ICD10|C|25|4|c|15}}, {{ICD10|D|13|7|d|10}} |
  ICD9          = {{ICD9|157.4}}, {{ICD9|211.7}} |
  ICDO          = 8151 |
  OMIM          = |
  MedlinePlus    = |
  MeshID        = D007340 |
}}
{{SI}}
'''Editor-in-Chief:''' [[C. Michael Gibson]], M.S.,M.D. [mailto:mgibson@perfuse.org]  Phone:617-632-7753; '''Associate Editor-In-Chief:''' Jinhui Wu, M.D.
'''Editor-in-Chief:''' [[C. Michael Gibson]], M.S.,M.D. [mailto:mgibson@perfuse.org]  Phone:617-632-7753; '''Associate Editor-In-Chief:''' Jinhui Wu, M.D.


==Overview==
==Overview==
An insulinoma is a benign tumor in the pancreas which is an organ in the abdomen that can make insulin to regulate blood sugar level. A patient of insulinoma can produce too much insulin. Patients may show a series of symptoms of hypoglycemia, such as anxiety, behavior changes, confusion, dizziness, headache and hunger. Treatments invlove surgery and medication.
An insulinoma is a tumor in the pancreas that produces too much insulin.
 
==What are the symptoms of insulinoma?==
Usual symptoms of insulinoma invlove a series of signs of hypoglycemia and other things:
 
*[[Hunger]]
 
*[[Sweating]]
 
*[[Palpitation]]
 
*[[Anxiety]]
 
*[[Behavior changes]]
 
*[[Clouded vision]]
 
*[[Convulsions]]
 
*[[Dizziness]]
 
*[[Headache]]


*[[Confusion]], even [[loss of consciousness]]
==What are the symptoms of Insulinoma?==
* Anxiety
*[[Tremor]]
* Behavior changes
* Clouded vision
* Confusion
* Convulsions
* Dizziness
* Headache
* Hunger
* Loss of consciousness
* Rapid heart rate
* Sweating
* Tremor
* Weight gain


*[[Weight gain]]
==Diagnosis==
After fasting, your blood may be tested for:


Other health problems may also cause these symptoms. Only a doctor can tell for sure. A person with any of these symptoms should tell the doctor so that the problems can be diagnosed and treated as early as possible.
* Blood C-peptide level
* Blood glucose level
* Blood insulin level
* Drugs that cause the pancreas to release insulin


==Who is at risk for insulinoma?==
CT or MRI scan of the abdomen may be done to look for a tumor in the pancreas. If the test is negative, one of the following tests may be performed:
The cause of insulinoma is not clear.


==How to know you have insulinoma?==
* Endoscopic ultrasound
*'''Blood tests:''' The patient needs to test the blood level of glucose, insulin and [[C-peptide]], when suspected to diagnose insulinoma.
* Octreotide scan
*'''Insulin suppression tests:''' This test is done to see whether insulin levels fail to suppress, which is a strong indicator of the presence of an insulin-secreting tumour.
* Pancreatic arteriography
*'''[[Computed tomography]] ([[CT]]) scan:''' CT scans are often used to diagnose insulinoma. It can confirm the location of the tumor and show the organs near the [[pancreas]].
* Pancreatic venous sampling for insulin
*'''[[Magnetic resonance imaging]] ([[MRI]]):''' An [[MRI]] uses magnetic fields but it is a different type of image than what is produced by computed tomography (CT) and produces detailed images of the body. Like computed tomography (CT), a contrast agent may be injected into a patient’s vein to create a better picture.


==When to seek urgent medical care?==
==When to seek urgent medical care?==
Call your health care provider if symptoms of insulinoma develop. If you experience either of the following symptoms, seeking urgent medical care as soon as possible:
Call your health care provider if you develop any symptoms of insulinoma. Convulsions and decreased consciousness are an emergency -- call 911 or your local emergency number.
 
*[[Convulsions]]
 
*[[Confusion]],
 
*Even [[loss of consciousness]]


==Treatment options==
==Treatment options==
For patients with insulinoma, surgery is the definitive management. Before treatment starts, ask your health care team about possible side effects and how treatment may change your normal activities.  
Surgery is the recommended treatment for insulinoma. The tumor is first found by tests or surgery. Medication may be used to get patients stable before surgery.
 
*Surgery: The surgical measure may involve surgical removal of the insulinoma and removing part of the pancreas such as Whipple procedure and distal pancreatectomy.
 
*Medication: For patients who may not accept surgery, medications such as diazoxide and somatostatin can be used to block the release of insulin.


==Diseases with similar symptoms==
If there is a single tumor it will be removed. However, if there are many tumors, part of the pancreas will need to be removed (partial pancreatectomy). At least 15% of the pancreas must be left to produce its enzymes. This may prevent the surgeon from removing the whole insulinoma tumor.
*[[Hypoglycemia]] by other causes


*[[Seizures]]
If no tumor is found during surgery, or if you are not a candidate for surgery, you may get the drug diazoxide to lower insulin production and avoid hypoglycemia. A diuretic (water pill) is given with this medication to prevent the body from retaining fluid. Octreotide is used to reduce insulin release in some patients.
 
*[[Stroke]]
 
*[[Schizophrenia]] or [[hysteria]]
 
==Where to find medical care for insulinoma?==


==Where to find medical care for Insulinoma?==
[http://maps.google.com/maps?f=q&hl=en&geocode=&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|insulinoma}}}}&sll=37.0625,-95.677068&sspn=65.008093,112.148438&ie=UTF8&ll=37.0625,-95.677068&spn=91.690419,149.414063&z=2&source=embed Directions to Hospitals Treating insulinoma]
[http://maps.google.com/maps?f=q&hl=en&geocode=&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|insulinoma}}}}&sll=37.0625,-95.677068&sspn=65.008093,112.148438&ie=UTF8&ll=37.0625,-95.677068&spn=91.690419,149.414063&z=2&source=embed Directions to Hospitals Treating insulinoma]


==Prevention of insulinoma==
==Prevention of Insulinoma==
For the cause is not clear, there is no known method for prevention.
For the cause is not clear, there is no known method for prevention.


==What to expect (Outook/Prognosis)?==
==What to expect (Outlook/Prognosis)?==
As a kind of benign tumor, the prognosis of insulinoma is good. Surgery can cure most patients. But a severe hypoglycemic reaction may be life-threatening for some patients.
As a kind of benign tumor, the prognosis of insulinoma is good. Surgery can cure most patients. But a severe hypoglycemic reaction may be life-threatening for some patients.


==Sources==
==Sources==
http://www.nlm.nih.gov/medlineplus/ency/article/000387.htm
http://www.nlm.nih.gov/medlineplus/ency/article/000387.htm
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[[Category:Disease state]]
[[Category:Disease state]]
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[[Category:Endocrinology patient information]]
[[Category:Endocrinology patient information]]
[[Category:Oncology patient information]]
[[Category:Oncology patient information]]
[[Category:Mature chapter]]
[[Category:Overview complete]]
[[Category:Template complete]]


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Revision as of 21:12, 15 September 2011

Insulinoma

Overview

What are the symptoms?

What are the causes?

Diagnosis

When to seek urgent medical care?

Treatment options

Where to find medical care for Insulinoma?

Prevention

What to expect (Outlook/Prognosis)?

Possible complications

Insulinoma On the Web

Ongoing Trials at Clinical Trials.gov

Images of Insulinoma

Videos on Insulinoma

FDA on Insulinoma

CDC on Insulinoma

Insulinoma in the news

Blogs on Insulinoma

Directions to Hospitals Treating Insulinoma

Risk calculators and risk factors for Insulinoma

For the WikiDoc page for this topic, click here

Editor-in-Chief: C. Michael Gibson, M.S.,M.D. [1] Phone:617-632-7753; Associate Editor-In-Chief: Jinhui Wu, M.D.

Overview

An insulinoma is a tumor in the pancreas that produces too much insulin.

What are the symptoms of Insulinoma?

  • Anxiety
  • Behavior changes
  • Clouded vision
  • Confusion
  • Convulsions
  • Dizziness
  • Headache
  • Hunger
  • Loss of consciousness
  • Rapid heart rate
  • Sweating
  • Tremor
  • Weight gain

Diagnosis

After fasting, your blood may be tested for:

  • Blood C-peptide level
  • Blood glucose level
  • Blood insulin level
  • Drugs that cause the pancreas to release insulin

CT or MRI scan of the abdomen may be done to look for a tumor in the pancreas. If the test is negative, one of the following tests may be performed:

  • Endoscopic ultrasound
  • Octreotide scan
  • Pancreatic arteriography
  • Pancreatic venous sampling for insulin

When to seek urgent medical care?

Call your health care provider if you develop any symptoms of insulinoma. Convulsions and decreased consciousness are an emergency -- call 911 or your local emergency number.

Treatment options

Surgery is the recommended treatment for insulinoma. The tumor is first found by tests or surgery. Medication may be used to get patients stable before surgery.

If there is a single tumor it will be removed. However, if there are many tumors, part of the pancreas will need to be removed (partial pancreatectomy). At least 15% of the pancreas must be left to produce its enzymes. This may prevent the surgeon from removing the whole insulinoma tumor.

If no tumor is found during surgery, or if you are not a candidate for surgery, you may get the drug diazoxide to lower insulin production and avoid hypoglycemia. A diuretic (water pill) is given with this medication to prevent the body from retaining fluid. Octreotide is used to reduce insulin release in some patients.

Where to find medical care for Insulinoma?

Directions to Hospitals Treating insulinoma

Prevention of Insulinoma

For the cause is not clear, there is no known method for prevention.

What to expect (Outlook/Prognosis)?

As a kind of benign tumor, the prognosis of insulinoma is good. Surgery can cure most patients. But a severe hypoglycemic reaction may be life-threatening for some patients.

Sources

http://www.nlm.nih.gov/medlineplus/ency/article/000387.htm

Template:WH Template:WS