ITPA: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Inosine triphosphate pyrophosphatase''' is an [[enzyme]] that in humans is encoded by the ''ITPA'' [[gene]],<ref name="pmid11278832">{{cite journal |vauthors=Lin S, McLennan AG, Ying K, Wang Z, Gu S, Jin H, Wu C, Liu W, Yuan Y, Tang R, Xie Y, Mao Y | title = Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the itpa gene | journal = J Biol Chem | volume = 276 | issue = 22 | pages = 18695–701 |date=May 2001 | pmid = 11278832 | pmc =  | doi = 10.1074/jbc.M011084200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3704| accessdate = }}</ref> by the ''rdgB'' [[gene]] in bacteria ''E.coli''<ref name="pmid 17090528">{{cite journal |vauthors=Burgis NE, Cunningham RP | title = Substrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase | journal = J Biol Chem | volume = 282 | issue = 8 | pages = 3531–8 | year = 2007 | pmid = 17090528 | doi = 10.1074/jbc.M608708200 }}</ref> and the ''HAM1'' [[gene]] in yeast ''S. cerevisiae''.<ref name="pmid 22531138">{{cite journal |vauthors=Davies O, Mendes P, Smallbone K, Malys N | title = Characterisation of multiple substrate-specific (d)ITP/(d)XTPase and modelling of deaminated purine nucleotide metabolism | journal = BMB Reports | volume = 45 | issue = 4 | pages = 259–64 | year = 2012 | pmid = 22531138| doi = 10.5483/BMBRep.2012.45.4.259 }}</ref>  Two transcript variants encoding two different isoforms have been found for this gene. Also, at least two other transcript variants have been identified which are probably regulatory rather than protein-coding.{{Citation needed|date=December 2016|reason=reference missing for the transcript variants}}
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_ITPA_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2car.
| PDB = {{PDB2|2car}}, {{PDB2|2i5d}}, {{PDB2|2j4e}}
| Name = Inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
| HGNCid = 6176
| Symbol = ITPA
| AltSymbols =; C20orf37; HLC14-06-P; ITPase; dJ794I6.3
| OMIM = 147520
| ECnumber = 
| Homologene = 6289
| MGIid = 96622
| GeneAtlas_image1 = PBB_GE_ITPA_209171_at_tn.png
| Function = {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0047429 |text = nucleoside-triphosphate diphosphatase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0009117 |text = nucleotide metabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3704
    | Hs_Ensembl = ENSG00000125877
    | Hs_RefseqProtein = NP_258412
    | Hs_RefseqmRNA = NM_033453
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 3138006
    | Hs_GenLoc_end = 3152511
    | Hs_Uniprot = Q9BY32
    | Mm_EntrezGene = 16434
    | Mm_Ensembl = ENSMUSG00000074797
    | Mm_RefseqmRNA = NM_025922
    | Mm_RefseqProtein = NP_080198
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 130359051
    | Mm_GenLoc_end = 130373055
    | Mm_Uniprot = Q60I30
  }}
}}
'''Inosine triphosphatase (nucleoside triphosphate pyrophosphatase)''', also known as '''ITPA''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3704| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The [[protein]] encoded by this gene [[hydrolyzes]] inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate.<ref name="entrez" /> The enzyme possesses a multiple substrate-specificity and acts on other nucleotides including [[xanthosine triphosphate]] and deoxyxanthosine triphosphate.<ref name="pmid 22531138"/> The encoded protein, which is a member of the HAM1 NTPase [[protein family]], is found in the [[cytoplasm]] and acts as a [[homodimer]].
{{PBB_Summary
 
| section_title =
== Clinical significance ==
| summary_text = The protein encoded by this gene hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. The encoded protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency. Two transcript variants encoding two different isoforms have been found for this gene. Also, at least two other transcript variants have been identified which are probably regulatory rather than protein-coding.<ref name="entrez">{{cite web | title = Entrez Gene: ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3704| accessdate = }}</ref>
 
}}
Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency.<ref name="entrez" />


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin |colwidth=33em}}
{{PBB_Further_reading
*{{cite journal  |vauthors=Holmes SL, Turner BM, Hirschhorn K |title=Human inosine triphosphatase: catalytic properties and population studies |journal=Clin. Chim. Acta |volume=97 |issue= 2–3 |pages= 143–53 |year= 1979 |pmid= 487601 |doi=10.1016/0009-8981(79)90410-8 }}
| citations =
*{{cite journal  | author=Fraser JH |title=Individual variation in inosine triphosphate accumulation in human erythrocytes |journal=Clin. Biochem. |volume=8 |issue= 6 |pages= 353–64 |year= 1976 |pmid= 1204209 |doi=10.1016/S0009-9120(75)93685-1 |name-list-format=vanc| author2=Meyers H | author3=Henderson JF  | display-authors=3  | last4=Brox  | first4=Larry W. | last5=McCoy  | first5=Ernest E. }}
*{{cite journal  | author=Holmes SL, Turner BM, Hirschhorn K |title=Human inosine triphosphatase: catalytic properties and population studies. |journal=Clin. Chim. Acta |volume=97 |issue= 2-3 |pages= 143-53 |year= 1979 |pmid= 487601 |doi=  }}
*{{cite journal  | author=Clawson GA |title=Interaction of human immunodeficiency virus type I Rev protein with nuclear scaffold nucleoside triphosphatase activity |journal=Cell Growth Differ. |volume=2 |issue= 11 |pages= 575–82 |year= 1992 |pmid= 1667585 |doi=  |name-list-format=vanc| author2=Song YL  | author3=Schwartz AM  | display-authors=3  | last4=Shukla  | first4=RR  | last5=Patel  | first5=SG  | last6=Connor  | first6=L  | last7=Blankenship  | first7=L  | last8=Hatem  | first8=C  | last9=Kumar  | first9=A  }}
*{{cite journal  | author=Fraser JH, Meyers H, Henderson JF, ''et al.'' |title=Individual variation in inosine triphosphate accumulation in human erythrocytes. |journal=Clin. Biochem. |volume=8 |issue= 6 |pages= 353-64 |year= 1976 |pmid= 1204209 |doi=  }}
*{{cite journal  | author=Deloukas P |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a  |name-list-format=vanc| author2=Matthews LH | author3=Ashurst J  | display-authors=3  | last4=Burton  | first4=J. | last5=Gilbert  | first5=J. G. R. | last6=Jones  | first6=M.  | last7=Stavrides  | first7=G.  | last8=Almeida  | first8=J. P. | last9=Babbage  | first9=A. K. }}
*{{cite journal | author=Clawson GA, Song YL, Schwartz AM, ''et al.'' |title=Interaction of human immunodeficiency virus type I Rev protein with nuclear scaffold nucleoside triphosphatase activity. |journal=Cell Growth Differ. |volume=2 |issue= 11 |pages= 575-82 |year= 1992 |pmid= 1667585 |doi=  }}
*{{cite journal  | author=Sumi S |title=Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency |journal=Hum. Genet. |volume=111 |issue= 4–5 |pages= 360–7 |year= 2002 |pmid= 12384777 |doi= 10.1007/s00439-002-0798-z |name-list-format=vanc| author2=Marinaki AM  | author3=Arenas M  | display-authors=3  | last4=Fairbanks  | first4=Lynette  | last5=Shobowale-Bakre  | first5=Monsor  | last6=Rees  | first6=David  | last7=Thein  | first7=Swee  | last8=Ansari  | first8=Azhar  | last9=Sanderson  | first9=Jeremy }}
*{{cite journal  | author=Lin S, McLennan AG, Ying K, ''et al.'' |title=Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the itpa gene. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 18695-701 |year= 2001 |pmid= 11278832 |doi= 10.1074/jbc.M011084200 }}
*{{cite journal  |vauthors=Cao H, Hegele RA |title=DNA polymorphisms in ITPA including basis of inosine triphosphatase deficiency |journal=J. Hum. Genet. |volume=47 |issue= 11 |pages= 620–2 |year= 2003 |pmid= 12436200 |doi= 10.1007/s100380200095 }}
*{{cite journal | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Sumi S, Marinaki AM, Arenas M, ''et al.'' |title=Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency. |journal=Hum. Genet. |volume=111 |issue= 4-5 |pages= 360-7 |year= 2002 |pmid= 12384777 |doi= 10.1007/s00439-002-0798-z }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G | last7=Klein  | first7=SL  | last8=Old  | first8=S | last9=Rasooly  | first9=R }}
*{{cite journal | author=Cao H, Hegele RA |title=DNA polymorphisms in ITPA including basis of inosine triphosphatase deficiency. |journal=J. Hum. Genet. |volume=47 |issue= 11 |pages= 620-2 |year= 2003 |pmid= 12436200 |doi= 10.1007/s100380200095 }}
*{{cite journal  | author=Marinaki AM |title=Mutation in the ITPA gene predicts intolerance to azathioprine |journal=Nucleosides Nucleotides Nucleic Acids |volume=23 |issue= 8–9 |pages= 1393–7 |year= 2005 |pmid= 15571265 |doi=10.1081/NCN-200027639 |name-list-format=vanc| author2=Duley JA  | author3=Arenas M  | display-authors=3  | last4=Ansari  | first4=A.  | last5=Sumi  | first5=S.  | last6=Lewis  | first6=C. M. | last7=Shobowale‐Bakre  | first7=M.  | last8=Fairbanks  | first8=L. D.  | last9=Sanderson  | first9=J.  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Marinaki AM |title=Allele frequency of inosine triphosphate pyrophosphatase gene polymorphisms in a Japanese population |journal=Nucleosides Nucleotides Nucleic Acids |volume=23 |issue= 8–9 |pages= 1399–401 |year= 2005 |pmid= 15571266 |doi=10.1081/NCN-200027641  |name-list-format=vanc| author2=Sumi S  | author3=Arenas M  | display-authors=3  | last4=Fairbanks  | first4=L.  | last5=Harihara  | first5=S.  | last6=Shimizu  | first6=K.  | last7=Ueta  | first7=A.  | last8=Duley  | first8=J. A.  }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Maeda T |title=Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency in the Japanese population |journal=Mol. Genet. Metab. |volume=85 |issue= 4 |pages= 271–9 |year= 2005 |pmid= 15946879 |doi= 10.1016/j.ymgme.2005.03.011  |name-list-format=vanc| author2=Sumi S  | author3=Ueta A  | display-authors=3  | last4=Ohkubo  | first4=Yumiko  | last5=Ito  | first5=Tetsuya  | last6=Marinaki  | first6=Anthony M.  | last7=Kurono  | first7=Yukihisa  | last8=Hasegawa  | first8=Shinsaku  | last9=Togari  | first9=Hajime }}
*{{cite journal  | author=Marinaki AM, Duley JA, Arenas M, ''et al.'' |title=Mutation in the ITPA gene predicts intolerance to azathioprine. |journal=Nucleosides Nucleotides Nucleic Acids |volume=23 |issue= 8-9 |pages= 1393-7 |year= 2005 |pmid= 15571265 |doi= }}
*{{cite journal  |vauthors=Breen DP, Marinaki AM, Arenas M, Hayes PC |title=Pharmacogenetic association with adverse drug reactions to azathioprine immunosuppressive therapy following liver transplantation |journal=Liver Transpl. |volume=11 |issue= 7 |pages= 826–33 |year= 2005 |pmid= 15973722 |doi= 10.1002/lt.20377 }}
*{{cite journal  | author=Marinaki AM, Sumi S, Arenas M, ''et al.'' |title=Allele frequency of inosine triphosphate pyrophosphatase gene polymorphisms in a Japanese population. |journal=Nucleosides Nucleotides Nucleic Acids |volume=23 |issue= 8-9 |pages= 1399-401 |year= 2005 |pmid= 15571266 |doi=  }}
*{{cite journal  | author=Porta J |title=Structure of the orthorhombic form of human inosine triphosphate pyrophosphatase |journal=Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. |volume=62 |issue= Pt 11 |pages= 1076–81 |year= 2006 |pmid= 17077483 |doi= 10.1107/S1744309106041790  | pmc=2225220  |name-list-format=vanc| author2=Kolar C  | author3=Kozmin SG  | display-authors=3  | last4=Pavlov  | first4=Youri I.  | last5=Borgstahl  | first5=Gloria E. O. }}
*{{cite journal | author=Maeda T, Sumi S, Ueta A, ''et al.'' |title=Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency in the Japanese population. |journal=Mol. Genet. Metab. |volume=85 |issue= 4 |pages= 271-9 |year= 2005 |pmid= 15946879 |doi= 10.1016/j.ymgme.2005.03.011 }}
*{{cite journal  | author=Arenas M |title=The ITPA c.94C>A and g.IVS2+21A>C sequence variants contribute to missplicing of the ITPA gene |journal=Biochim. Biophys. Acta |volume=1772 |issue= 1 |pages= 96–102 |year= 2007 |pmid= 17113761 |doi= 10.1016/j.bbadis.2006.10.006  |name-list-format=vanc| author2=Duley J  | author3=Sumi S  | display-authors=3  | last4=Sanderson  | first4=Jeremy  | last5=Marinaki  | first5=Anthony }}
*{{cite journal  | author=Breen DP, Marinaki AM, Arenas M, Hayes PC |title=Pharmacogenetic association with adverse drug reactions to azathioprine immunosuppressive therapy following liver transplantation. |journal=Liver Transpl. |volume=11 |issue= 7 |pages= 826-33 |year= 2005 |pmid= 15973722 |doi= 10.1002/lt.20377 }}
*{{cite journal  | author=Stenmark P |title=Crystal structure of human inosine triphosphatase. Substrate binding and implication of the inosine triphosphatase deficiency mutation P32T |journal=J. Biol. Chem. |volume=282 |issue= 5 |pages= 3182–7 |year= 2007 |pmid= 17138556 |doi= 10.1074/jbc.M609838200  |name-list-format=vanc| author2=Kursula P  | author3=Flodin S  | display-authors=3  | last4=Graslund  | first4=S.  | last5=Landry  | first5=R.  | last6=Nordlund  | first6=P.  | last7=Schuler  | first7=H. }}
*{{cite journal | author=Porta J, Kolar C, Kozmin SG, ''et al.'' |title=Structure of the orthorhombic form of human inosine triphosphate pyrophosphatase. |journal=Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. |volume=62 |issue= Pt 11 |pages= 1076-81 |year= 2006 |pmid= 17077483 |doi= 10.1107/S1744309106041790 }}
*{{cite journal  | author=Atanasova S |title=Analysis of ITPA phenotype-genotype correlation in the Bulgarian population revealed a novel gene variant in exon 6 |journal=Therapeutic drug monitoring |volume=29 |issue= 1 |pages= 6–10 |year= 2007 |pmid= 17304144 |doi= 10.1097/FTD.0b013e3180308554  |name-list-format=vanc| author2=Shipkova M  | author3=Svinarov D  | display-authors=3  | last4=Mladenova  | first4=Antoaneta  | last5=Genova  | first5=Mariana  | last6=Wieland  | first6=Eberhard  | last7=Oellerich  | first7=Michael  | last8=Ahsen  | first8=Nicolas von }}
*{{cite journal | author=Arenas M, Duley J, Sumi S, ''et al.'' |title=The ITPA c.94C>A and g.IVS2+21A>C sequence variants contribute to missplicing of the ITPA gene. |journal=Biochim. Biophys. Acta |volume=1772 |issue= 1 |pages= 96-102 |year= 2007 |pmid= 17113761 |doi= 10.1016/j.bbadis.2006.10.006 }}
*{{cite journal | author=Stenmark P, Kursula P, Flodin S, ''et al.'' |title=Crystal structure of human inosine triphosphatase. Substrate binding and implication of the inosine triphosphatase deficiency mutation P32T. |journal=J. Biol. Chem. |volume=282 |issue= 5 |pages= 3182-7 |year= 2007 |pmid= 17138556 |doi= 10.1074/jbc.M609838200 }}
*{{cite journal  | author=Atanasova S, Shipkova M, Svinarov D, ''et al.'' |title=Analysis of ITPA phenotype-genotype correlation in the Bulgarian population revealed a novel gene variant in exon 6. |journal=Therapeutic drug monitoring |volume=29 |issue= 1 |pages= 6-10 |year= 2007 |pmid= 17304144 |doi= 10.1097/FTD.0b013e3180308554 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=3704}}
{{WikiDoc Sources}}
 
 
{{gene-20-stub}}

Revision as of 00:12, 1 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Inosine triphosphate pyrophosphatase is an enzyme that in humans is encoded by the ITPA gene,[1][2] by the rdgB gene in bacteria E.coli[3] and the HAM1 gene in yeast S. cerevisiae.[4] Two transcript variants encoding two different isoforms have been found for this gene. Also, at least two other transcript variants have been identified which are probably regulatory rather than protein-coding.[citation needed]

Function

The protein encoded by this gene hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate.[2] The enzyme possesses a multiple substrate-specificity and acts on other nucleotides including xanthosine triphosphate and deoxyxanthosine triphosphate.[4] The encoded protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer.

Clinical significance

Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency.[2]

References

  1. ↑ Lin S, McLennan AG, Ying K, Wang Z, Gu S, Jin H, Wu C, Liu W, Yuan Y, Tang R, Xie Y, Mao Y (May 2001). "Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the itpa gene". J Biol Chem. 276 (22): 18695–701. doi:10.1074/jbc.M011084200. PMID 11278832.
  2. ↑ 2.0 2.1 2.2 "Entrez Gene: ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase)".
  3. ↑ Burgis NE, Cunningham RP (2007). "Substrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase". J Biol Chem. 282 (8): 3531–8. doi:10.1074/jbc.M608708200. PMID 17090528.
  4. ↑ 4.0 4.1 Davies O, Mendes P, Smallbone K, Malys N (2012). "Characterisation of multiple substrate-specific (d)ITP/(d)XTPase and modelling of deaminated purine nucleotide metabolism". BMB Reports. 45 (4): 259–64. doi:10.5483/BMBRep.2012.45.4.259. PMID 22531138.

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=ITPA&oldid=1419760"