ITGA8: Difference between revisions

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Latest revision as of 20:08, 8 November 2017

Integrin alpha-8 is a protein that in humans is encoded by the ITGA8 gene.^[1]^[2]

References

↑ Schnapp LM, Breuss JM, Ramos DM, Sheppard D, Pytela R (Jul 1995). "Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells". J Cell Sci. 108 (2): 537–44. PMID 7768999.
↑ "Entrez Gene: ITGA8 integrin, alpha 8".

Schnapp LM, Hatch N, Ramos DM, et al. (1995). "The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin". J. Biol. Chem. 270 (39): 23196–202. doi:10.1074/jbc.270.39.23196. PMID 7559467.
Denda S, Müller U, Crossin KL, et al. (1998). "Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: murine alpha 8 beta 1 binds to the RGD site in tenascin-C fragments, but not to native tenascin-C". Biochemistry. 37 (16): 5464–74. doi:10.1021/bi9727489. PMC 2710129. PMID 9548928.
Hartner A, Schöcklmann H, Pröls F, et al. (1999). "Alpha8 integrin in glomerular mesangial cells and in experimental glomerulonephritis". Kidney Int. 56 (4): 1468–80. doi:10.1046/j.1523-1755.1999.00662.x. PMID 10504498.
Littlewood Evans A, Müller U (2000). "Stereocilia defects in the sensory hair cells of the inner ear in mice deficient in integrin alpha8beta1". Nat. Genet. 24 (4): 424–8. doi:10.1038/74286. PMID 10742111.
Brandenberger R, Schmidt A, Linton J, et al. (2001). "Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin alpha8beta1 in the embryonic kidney". J. Cell Biol. 154 (2): 447–58. doi:10.1083/jcb.200103069. PMC 2150762. PMID 11470831.
Ljubimov AV, Saghizadeh M, Pytela R, et al. (2001). "Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas". J. Histochem. Cytochem. 49 (11): 1341–50. doi:10.1177/002215540104901102. PMID 11668187.
Valerius MT, Patterson LT, Feng Y, Potter SS (2002). "Hoxa 11 is upstream of Integrin alpha8 expression in the developing kidney". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 8090–5. doi:10.1073/pnas.122229199. PMC 123025. PMID 12060755.
Lu M, Munger JS, Steadele M, et al. (2003). "Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1". J. Cell Sci. 115 (Pt 23): 4641–8. doi:10.1242/jcs.00145. PMID 12415008.
Bieritz B, Spessotto P, Colombatti A, et al. (2004). "Role of alpha8 integrin in mesangial cell adhesion, migration, and proliferation". Kidney Int. 64 (1): 119–27. doi:10.1046/j.1523-1755.2003.00057.x. PMID 12787402.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Ekwa-Ekoka C, Diaz GA, Carlson C, et al. (2005). "Genomic organization and sequence variation of the human integrin subunit alpha8 gene (ITGA8)". Matrix Biol. 23 (7): 487–96. doi:10.1016/j.matbio.2004.08.005. PMID 15579315.
Scherberich A, Tucker RP, Degen M, et al. (2005). "Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin-dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro". Oncogene. 24 (9): 1525–32. doi:10.1038/sj.onc.1208342. PMID 15592496.

External links

ITGA8 Info with links in the Cell Migration Gateway

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

[pmid7768999-1] Schnapp LM, Breuss JM, Ramos DM, Sheppard D, Pytela R (Jul 1995). "Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells". J Cell Sci. 108 (2): 537–44. PMID 7768999.

[entrez-2] "Entrez Gene: ITGA8 integrin, alpha 8".

[1]

[2]

@@ Line 1: / Line 1: @@
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+{{Underlinked|date=November 2017}}
-{{PBB_Controls
+{{Infobox_gene}}
-| update_page = yes
+'''Integrin alpha-8''' is a [[protein]] that in humans is encoded by the ''ITGA8'' [[gene]].<ref name="pmid7768999">{{cite journal |vauthors=Schnapp LM, Breuss JM, Ramos DM, Sheppard D, Pytela R | title = Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells | journal = J Cell Sci | volume = 108 | issue =  2| pages = 537–44 |date=Jul 1995 | pmid = 7768999 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ITGA8 integrin, alpha 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8516| accessdate = }}</ref>
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-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Integrin, alpha 8
- | HGNCid = 6144
- | Symbol = ITGA8
- | AltSymbols =;
- | OMIM = 604063
- | ECnumber =
- | Homologene = 37396
- | MGIid = 109442
- | GeneAtlas_image1 = PBB_GE_ITGA8_214265_at_tn.png
- | Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
- | Component = {{GNF_GO|id=GO:0008305 |text = integrin complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
- | Process = {{GNF_GO|id=GO:0007160 |text = cell-matrix adhesion}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}} {{GNF_GO|id=GO:0007613 |text = memory}} {{GNF_GO|id=GO:0016337 |text = cell-cell adhesion}}
-  | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 8516
-    | Hs_Ensembl = ENSG00000077943
-    | Hs_RefseqProtein = NP_003629
-    | Hs_RefseqmRNA = NM_003638
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 10
-    | Hs_GenLoc_start = 15595954
-    | Hs_GenLoc_end = 15802130
-    | Hs_Uniprot = P53708
-    | Mm_EntrezGene = 241226
-    | Mm_Ensembl = ENSMUSG00000026768
-    | Mm_RefseqmRNA = NM_001001309
-    | Mm_RefseqProtein = NP_001001309
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 2
-    | Mm_GenLoc_start = 12024513
-    | Mm_GenLoc_end = 12219773
-    | Mm_Uniprot =
-  }}
-}}
-'''Integrin, alpha 8''', also known as '''ITGA8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ITGA8 integrin, alpha 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8516| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
@@ Line 55: / Line 10: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Schnapp LM, Hatch N, Ramos DM, ''et al.'' |title=The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin. |journal=J. Biol. Chem. |volume=270 |issue= 39 |pages= 23196-202 |year= 1995 |pmid= 7559467 |doi=  }}
+*{{cite journal   |vauthors=Schnapp LM, Hatch N, Ramos DM, etal |title=The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin. |journal=J. Biol. Chem. |volume=270 |issue= 39 |pages= 23196–202 |year= 1995 |pmid= 7559467 |doi=10.1074/jbc.270.39.23196  }}
-*{{cite journal  | author=Schnapp LM, Breuss JM, Ramos DM, ''et al.'' |title=Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells. |journal=J. Cell. Sci. |volume=108 ( Pt 2) |issue=  |pages= 537-44 |year= 1995 |pmid= 7768999 |doi=  }}
+*{{cite journal   |vauthors=Denda S, Müller U, Crossin KL, etal |title=Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: murine alpha 8 beta 1 binds to the RGD site in tenascin-C fragments, but not to native tenascin-C. |journal=Biochemistry |volume=37 |issue= 16 |pages= 5464–74 |year= 1998 |pmid= 9548928 |doi= 10.1021/bi9727489  | pmc=2710129 }}
-*{{cite journal  | author=Denda S, Müller U, Crossin KL, ''et al.'' |title=Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: murine alpha 8 beta 1 binds to the RGD site in tenascin-C fragments, but not to native tenascin-C. |journal=Biochemistry |volume=37 |issue= 16 |pages= 5464-74 |year= 1998 |pmid= 9548928 |doi= 10.1021/bi9727489 }}
+*{{cite journal   |vauthors=Hartner A, Schöcklmann H, Pröls F, etal |title=Alpha8 integrin in glomerular mesangial cells and in experimental glomerulonephritis. |journal=Kidney Int. |volume=56 |issue= 4 |pages= 1468–80 |year= 1999 |pmid= 10504498 |doi= 10.1046/j.1523-1755.1999.00662.x }}
-*{{cite journal  | author=Hartner A, Schöcklmann H, Pröls F, ''et al.'' |title=Alpha8 integrin in glomerular mesangial cells and in experimental glomerulonephritis. |journal=Kidney Int. |volume=56 |issue= 4 |pages= 1468-80 |year= 1999 |pmid= 10504498 |doi= 10.1046/j.1523-1755.1999.00662.x }}
+*{{cite journal  |vauthors=Littlewood Evans A, Müller U |title=Stereocilia defects in the sensory hair cells of the inner ear in mice deficient in integrin alpha8beta1. |journal=Nat. Genet. |volume=24 |issue= 4 |pages= 424–8 |year= 2000 |pmid= 10742111 |doi= 10.1038/74286 }}
-*{{cite journal  | author=Littlewood Evans A, Müller U |title=Stereocilia defects in the sensory hair cells of the inner ear in mice deficient in integrin alpha8beta1. |journal=Nat. Genet. |volume=24 |issue= 4 |pages= 424-8 |year= 2000 |pmid= 10742111 |doi= 10.1038/74286 }}
+*{{cite journal   |vauthors=Brandenberger R, Schmidt A, Linton J, etal |title=Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin alpha8beta1 in the embryonic kidney. |journal=J. Cell Biol. |volume=154 |issue= 2 |pages= 447–58 |year= 2001 |pmid= 11470831 |doi=10.1083/jcb.200103069  | pmc=2150762  }}
-*{{cite journal  | author=Brandenberger R, Schmidt A, Linton J, ''et al.'' |title=Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin alpha8beta1 in the embryonic kidney. |journal=J. Cell Biol. |volume=154 |issue= 2 |pages= 447-58 |year= 2001 |pmid= 11470831 |doi=  }}
+*{{cite journal   |vauthors=Ljubimov AV, Saghizadeh M, Pytela R, etal |title=Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas. |journal=J. Histochem. Cytochem. |volume=49 |issue= 11 |pages= 1341–50 |year= 2001 |pmid= 11668187 |doi=  10.1177/002215540104901102}}
-*{{cite journal  | author=Ljubimov AV, Saghizadeh M, Pytela R, ''et al.'' |title=Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas. |journal=J. Histochem. Cytochem. |volume=49 |issue= 11 |pages= 1341-50 |year= 2001 |pmid= 11668187 |doi=  }}
+*{{cite journal  |vauthors=Valerius MT, Patterson LT, Feng Y, Potter SS |title=Hoxa 11 is upstream of Integrin alpha8 expression in the developing kidney. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 12 |pages= 8090–5 |year= 2002 |pmid= 12060755 |doi= 10.1073/pnas.122229199  | pmc=123025 }}
-*{{cite journal  | author=Valerius MT, Patterson LT, Feng Y, Potter SS |title=Hoxa 11 is upstream of Integrin alpha8 expression in the developing kidney. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 12 |pages= 8090-5 |year= 2002 |pmid= 12060755 |doi= 10.1073/pnas.122229199 }}
+*{{cite journal   |vauthors=Lu M, Munger JS, Steadele M, etal |title=Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1. |journal=J. Cell Sci. |volume=115 |issue= Pt 23 |pages= 4641–8 |year= 2003 |pmid= 12415008 |doi=10.1242/jcs.00145  }}
-*{{cite journal  | author=Lu M, Munger JS, Steadele M, ''et al.'' |title=Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1. |journal=J. Cell. Sci. |volume=115 |issue= Pt 23 |pages= 4641-8 |year= 2003 |pmid= 12415008 |doi=  }}
+*{{cite journal   |vauthors=Bieritz B, Spessotto P, Colombatti A, etal |title=Role of alpha8 integrin in mesangial cell adhesion, migration, and proliferation. |journal=Kidney Int. |volume=64 |issue= 1 |pages= 119–27 |year= 2004 |pmid= 12787402 |doi= 10.1046/j.1523-1755.2003.00057.x }}
-*{{cite journal  | author=Bieritz B, Spessotto P, Colombatti A, ''et al.'' |title=Role of alpha8 integrin in mesangial cell adhesion, migration, and proliferation. |journal=Kidney Int. |volume=64 |issue= 1 |pages= 119-27 |year= 2004 |pmid= 12787402 |doi= 10.1046/j.1523-1755.2003.00057.x }}
+*{{cite journal   |vauthors=Deloukas P, Earthrowl ME, Grafham DV, etal |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 }}
-*{{cite journal  | author=Deloukas P, Earthrowl ME, Grafham DV, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375-81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 }}
+*{{cite journal   |vauthors=Ekwa-Ekoka C, Diaz GA, Carlson C, etal |title=Genomic organization and sequence variation of the human integrin subunit alpha8 gene (ITGA8). |journal=Matrix Biol. |volume=23 |issue= 7 |pages= 487–96 |year= 2005 |pmid= 15579315 |doi= 10.1016/j.matbio.2004.08.005 }}
-*{{cite journal  | author=Ekwa-Ekoka C, Diaz GA, Carlson C, ''et al.'' |title=Genomic organization and sequence variation of the human integrin subunit alpha8 gene (ITGA8). |journal=Matrix Biol. |volume=23 |issue= 7 |pages= 487-96 |year= 2005 |pmid= 15579315 |doi= 10.1016/j.matbio.2004.08.005 }}
+*{{cite journal   |vauthors=Scherberich A, Tucker RP, Degen M, etal |title=Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin-dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro. |journal=Oncogene |volume=24 |issue= 9 |pages= 1525–32 |year= 2005 |pmid= 15592496 |doi= 10.1038/sj.onc.1208342 }}
-*{{cite journal  | author=Scherberich A, Tucker RP, Degen M, ''et al.'' |title=Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin-dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro. |journal=Oncogene |volume=24 |issue= 9 |pages= 1525-32 |year= 2005 |pmid= 15592496 |doi= 10.1038/sj.onc.1208342 }}
 }}
 {{refend}}
-{{protein-stub}}
+==External links==
-{{WikiDoc Sources}}
+*[http://cmkb.cellmigration.org/report.cgi?report=orth_overview&gene_id=8516 ITGA8] Info with links in the [http://www.cellmigration.org/index.shtml Cell Migration Gateway]
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
+{{Integrins}}
+[[Category:Integrins]]
+{{gene-10-stub}}

ITGA8: Difference between revisions

Latest revision as of 20:08, 8 November 2017

References

Further reading

External links

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