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Interferon regulatory factor 5
Symbols IRF5 ;
External IDs OMIM: 607218 MGI1350924 HomoloGene8088
RNA expression pattern
PBB GE IRF5 205469 s at tn.png
PBB GE IRF5 205468 s at tn.png
More reference expression data

| | bgcolor="#C3FDB8" | Human | bgcolor="#C3FDB8" | Mouse |-

    | bgcolor="#C3FDB8" | Entrez 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 3663
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 27056


     | bgcolor="#C3FDB8" | Ensembl
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSG00000128604
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSMUSG00000029771


    | bgcolor="#C3FDB8" | Uniprot
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| Q13568
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| Q3U169


    | bgcolor="#C3FDB8" | Refseq
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" | NM_002200 (mRNA)
NP_002191 (protein)
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" |NM_012057 (mRNA)
NP_036187 (protein)


    | bgcolor="#C3FDB8" | Location
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 7: 128.37 - 128.38 Mb 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 6: 29.48 -  29.49 Mb 



    | bgcolor="#C3FDB8" | Pubmed search 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [1]
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [2]
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Interferon regulatory factor 5, also known as IRF5, is a human gene.[1]

This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative splice variants encoding different isoforms exist.[1]

See also


  1. 1.0 1.1 "Entrez Gene: IRF5 interferon regulatory factor 5".

Further reading

  • Pitha PM, Au WC, Lowther W; et al. (1999). "Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth". Biochimie. 80 (8–9): 651–8. PMID 9865487.
  • Barnes B, Lubyova B, Pitha PM (2002). "On the role of IRF in host defense". J. Interferon Cytokine Res. 22 (1): 59–71. doi:10.1089/107999002753452665. PMID 11846976.
  • Barnes BJ, Moore PA, Pitha PM (2001). "Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes". J. Biol. Chem. 276 (26): 23382–90. doi:10.1074/jbc.M101216200. PMID 11303025.
  • Nehyba J, Hrdlicková R, Burnside J, Bose HR (2002). "A novel interferon regulatory factor (IRF), IRF-10, has a unique role in immune defense and is induced by the v-Rel oncoprotein". Mol. Cell. Biol. 22 (11): 3942–57. PMID 11997525.
  • Barnes BJ, Kellum MJ, Field AE, Pitha PM (2002). "Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes". Mol. Cell. Biol. 22 (16): 5721–40. PMID 12138184.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Barnes BJ, Field AE, Pitha-Rowe PM (2003). "Virus-induced heterodimer formation between IRF-5 and IRF-7 modulates assembly of the IFNA enhanceosome in vivo and transcriptional activity of IFNA genes". J. Biol. Chem. 278 (19): 16630–41. doi:10.1074/jbc.M212609200. PMID 12600985.
  • Scherer SW, Cheung J, MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.
  • Barnes BJ, Kellum MJ, Pinder KE; et al. (2003). "Interferon regulatory factor 5, a novel mediator of cell cycle arrest and cell death". Cancer Res. 63 (19): 6424–31. PMID 14559832.
  • Barnes BJ, Richards J, Mancl M; et al. (2004). "Global and distinct targets of IRF-5 and IRF-7 during innate response to viral infection". J. Biol. Chem. 279 (43): 45194–207. doi:10.1074/jbc.M400726200. PMID 15308637.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
  • Lin R, Yang L, Arguello M; et al. (2005). "A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization". J. Biol. Chem. 280 (4): 3088–95. doi:10.1074/jbc.M408452200. PMID 15556946.
  • Sigurdsson S, Nordmark G, Göring HH; et al. (2005). "Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus". Am. J. Hum. Genet. 76 (3): 528–37. doi:10.1086/428480. PMID 15657875.
  • Takaoka A, Yanai H, Kondo S; et al. (2005). "Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors". Nature. 434 (7030): 243–9. doi:10.1038/nature03308. PMID 15665823.
  • Schoenemeyer A, Barnes BJ, Mancl ME; et al. (2005). "The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling". J. Biol. Chem. 280 (17): 17005–12. doi:10.1074/jbc.M412584200. PMID 15695821.
  • Mancl ME, Hu G, Sangster-Guity N; et al. (2005). "Two discrete promoters regulate the alternatively spliced human interferon regulatory factor-5 isoforms. Multiple isoforms with distinct cell type-specific expression, localization, regulation, and function". J. Biol. Chem. 280 (22): 21078–90. doi:10.1074/jbc.M500543200. PMID 15805103.
  • Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Graham RR, Kozyrev SV, Baechler EC; et al. (2006). "A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus". Nat. Genet. 38 (5): 550–5. doi:10.1038/ng1782. PMID 16642019.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.