IL18BP

Interleukin 18 binding protein
Identifiers
Symbols	IL18BP ; IL18BPa
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7781
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Interleukin 18 binding protein, also known as IL18BP, is a human gene.

The protein encoded by this gene is an inhibitor of the proinflammatory cytokine IL18. This protein binds to IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production. This protein is constitutively expressed and secreted in mononuclear cells. The expression of this protein can be enhanced by IFN-gamma. An elevated level of this protein is detected in the intestinal tissues of patients with Crohn disease. Three transcript variants encoding the same protein have been found for this gene.

Further reading

• Dinarello CA (2002). "Novel targets for interleukin 18 binding protein". Ann. Rheum. Dis. 60 Suppl 3: iii18–24. PMID 11890646.
• Loughney K, Martins TJ, Harris EA; et al. (1996). "Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases". J. Biol. Chem. 271 (2): 796–806. PMID 8557689.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Novick D, Kim SH, Fantuzzi G; et al. (1999). "Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response". Immunity. 10 (1): 127–36. PMID 10023777.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aizawa Y, Akita K, Taniai M; et al. (1999). "Cloning and expression of interleukin-18 binding protein". FEBS Lett. 445 (2–3): 338–42. PMID 10094485.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xiang Y, Moss B (1999). "Identification of human and mouse homologs of the MC51L-53L-54L family of secreted glycoproteins encoded by the Molluscum contagiosum poxvirus". Virology. 257 (2): 297–302. doi:10.1006/viro.1999.9676. PMID 10329540.
• Kim SH, Eisenstein M, Reznikov L; et al. (2000). "Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18". Proc. Natl. Acad. Sci. U.S.A. 97 (3): 1190–5. PMID 10655506.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dias Neto E, Correa RG, Verjovski-Almeida S; et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Michibata H, Yanaka N, Kanoh Y; et al. (2001). "Human Ca2+/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localization". Biochim. Biophys. Acta. 1517 (2): 278–87. PMID 11342109.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Paulukat J, Bosmann M, Nold M; et al. (2001). "Expression and release of IL-18 binding protein in response to IFN-gamma". J. Immunol. 167 (12): 7038–43. PMID 11739524.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fidock M, Miller M, Lanfear J (2002). "Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants". Cell. Signal. 14 (1): 53–60. PMID 11747989.CS1 maint: Multiple names: authors list (link)
• Corbaz A, ten Hove T, Herren S; et al. (2002). "IL-18-binding protein expression by endothelial cells and macrophages is up-regulated during active Crohn's disease". J. Immunol. 168 (7): 3608–16. PMID 11907126.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bufler P, Azam T, Gamboni-Robertson F; et al. (2002). "A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13723–8. doi:10.1073/pnas.212519099. PMID 12381835.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hurgin V, Novick D, Rubinstein M (2003). "The promoter of IL-18 binding protein: activation by an IFN-gamma -induced complex of IFN regulatory factor 1 and CCAAT/enhancer binding protein beta". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16957–62. doi:10.1073/pnas.262663399. PMID 12482935.CS1 maint: Multiple names: authors list (link)
• Plitz T, Saint-Mézard P, Satho M; et al. (2003). "IL-18 binding protein protects against contact hypersensitivity". J. Immunol. 171 (3): 1164–71. PMID 12874202.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fantuzzi G, Banda NK, Guthridge C; et al. (2004). "Generation and characterization of mice transgenic for human IL-18-binding protein isoform a.". J. Leukoc. Biol. 74 (5): 889–96. doi:10.1189/jlb.0503230. PMID 12960225.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kawashima M, Novick D, Rubinstein M, Miossec P (2004). "Regulation of interleukin-18 binding protein production by blood and synovial cells from patients with rheumatoid arthritis". Arthritis Rheum. 50 (6): 1800–5. doi:10.1002/art.20320. PMID 15188356.CS1 maint: Multiple names: authors list (link)
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.