IFIT2: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Interferon-induced protein with tetratricopeptide repeats 2 or IFIT2 ''' is a [[protein]] found in humans which is encoded by the ''IFIT2'' [[gene]].<ref name="pmid3175763">{{cite journal | vauthors = Wathelet MG, Szpirer J, Nols CB, Clauss IM, De Wit L, Islam MQ, Levan G, Horisberger MA, Content J, Szpirer C | title = Cloning and chromosomal location of human genes inducible by type I interferon | journal = Somat Cell Mol Genet | volume = 14 | issue = 5 | pages = 415–26 | date = Nov 1988 | pmid = 3175763 | pmc =  | doi = 10.1007/BF01534709}}</ref><ref name="pmid3360121">{{cite journal | vauthors = Wathelet MG, Clauss IM, Content J, Huez GA | title = The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family | journal = FEBS Lett | volume = 231 | issue = 1 | pages = 164–71 | date = Jun 1988 | pmid = 3360121 | pmc =  | doi = 10.1016/0014-5793(88)80724-5 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: IFIT2 interferon-induced protein with tetratricopeptide repeats 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3433| accessdate = }}</ref>
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== Clinical significance ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Interferon-induced protein with tetratricopeptide repeats 2
| HGNCid = 5409
| Symbol = IFIT2
| AltSymbols =; G10P2; GARG-39; IFI-54; IFI54; ISG-54K; ISG54; cig42
| OMIM = 147040
| ECnumber = 
| Homologene = 1187
| MGIid = 99449
| GeneAtlas_image1 = PBB_GE_IFIT2_217502_at_tn.png
| Function = {{GNF_GO|id=GO:0005488 |text = binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3433
    | Hs_Ensembl = ENSG00000119922
    | Hs_RefseqProtein = NP_001538
    | Hs_RefseqmRNA = NM_001547
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 91051692
    | Hs_GenLoc_end = 91059013
    | Hs_Uniprot = P09913
    | Mm_EntrezGene = 15958
    | Mm_Ensembl = ENSMUSG00000045932
    | Mm_RefseqmRNA = NM_008332
    | Mm_RefseqProtein = NP_032358
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 34616707
    | Mm_GenLoc_end = 34642416
    | Mm_Uniprot = Q6GTM0
  }}
}}
'''Interferon-induced protein with tetratricopeptide repeats 2''', also known as '''IFIT2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IFIT2 interferon-induced protein with tetratricopeptide repeats 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3433| accessdate = }}</ref>


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IFIT2 may play a role in prevention of [[tumor]] progression.<ref name="pmid18819931">{{cite journal | vauthors = Lai KC, Chang KW, Liu CJ, Kao SY, Lee TC | title = IFN-induced protein with tetratricopeptide repeats 2 inhibits migration activity and increases survival of oral squamous cell carcinoma | journal = Mol. Cancer Res. | volume = 6 | issue = 9 | pages = 1431–9 | year = 2008 | pmid = 18819931 | doi = 10.1158/1541-7786.MCR-08-0141 | url = }}</ref>
{{PBB_Summary
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| summary_text =
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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Lafage M, Clauss I, Couez D, Simonetti J, Wathelet MG, Huez G | title = The interferon- and virus-inducible IFI-56K and IFI-54K genes are located on human chromosome 10 at bands q23-q24 | journal = Genomics | volume = 13 | issue = 2 | pages = 458–60 | year = 1992 | pmid = 1377167 | doi = 10.1016/0888-7543(92)90272-T }}
| citations =
* {{cite journal | vauthors = Wathelet MG, Clauss IM, Content J, Huez GA | title = Regulation of two interferon-inducible human genes by interferon, poly(rI).poly(rC) and viruses | journal = Eur. J. Biochem. | volume = 174 | issue = 2 | pages = 323–9 | year = 1988 | pmid = 2454816 | doi = 10.1111/j.1432-1033.1988.tb14101.x }}
*{{cite journal | author=Lafage M, Clauss I, Couez D, ''et al.'' |title=The interferon- and virus-inducible IFI-56K and IFI-54K genes are located on human chromosome 10 at bands q23-q24. |journal=Genomics |volume=13 |issue= 2 |pages= 458-60 |year= 1992 |pmid= 1377167 |doi= }}
* {{cite journal | vauthors = Ulker N, Zhang X, Samuel CE | title = Mechanism of interferon action. I. Characterization of a 54-kDa protein induced by gamma interferon with properties similar to a cytoskeletal component | journal = J. Biol. Chem. | volume = 262 | issue = 35 | pages = 16798–803 | year = 1988 | pmid = 3119591 | doi =  }}
*{{cite journal | author=Wathelet MG, Clauss IM, Content J, Huez GA |title=Regulation of two interferon-inducible human genes by interferon, poly(rI).poly(rC) and viruses. |journal=Eur. J. Biochem. |volume=174 |issue= 2 |pages= 323-9 |year= 1988 |pmid= 2454816 |doi= }}
* {{cite journal | vauthors = Levy D, Larner A, Chaudhuri A, Babiss LE, Darnell JE | title = Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 83 | issue = 23 | pages = 8929–33 | year = 1987 | pmid = 3466167 | pmc = 387047 | doi = 10.1073/pnas.83.23.8929 }}
*{{cite journal | author=Ulker N, Zhang X, Samuel CE |title=Mechanism of interferon action. I. Characterization of a 54-kDa protein induced by gamma interferon with properties similar to a cytoskeletal component. |journal=J. Biol. Chem. |volume=262 |issue= 35 |pages= 16798-803 |year= 1988 |pmid= 3119591 |doi=  }}
* {{cite journal | vauthors = Zhu H, Cong JP, Shenk T | title = Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: Induction of interferon-responsive RNAs | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 25 | pages = 13985–90 | year = 1998 | pmid = 9391139 | pmc = 28419 | doi = 10.1073/pnas.94.25.13985 }}
*{{cite journal | author=Wathelet MG, Szpirer J, Nols CB, ''et al.'' |title=Cloning and chromosomal location of human genes inducible by type I interferon. |journal=Somat. Cell Mol. Genet. |volume=14 |issue= 5 |pages= 415-26 |year= 1988 |pmid= 3175763 |doi=  }}
* {{cite journal | vauthors = Gavrilov BG, Monastyrskaia GS, Velikodvorskaia TV, Filiukova OB, Konovalova SN, Kachko AA, Protopopova EV, Nikolaev LG, Loktev VB, Sverdlov ED | title = [Late activation of interferon-induced genes IFI-54k and IFI-56k in human RH cells infected with tick-borne encephalitis virus] | journal = Bioorg. Khim. | volume = 29 | issue = 2 | pages = 175–80 | year = 2003 | pmid = 12708317 | doi =  }}
*{{cite journal  | author=Wathelet MG, Clauss IM, Content J, Huez GA |title=The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family. |journal=FEBS Lett. |volume=231 |issue= 1 |pages= 164-71 |year= 1988 |pmid= 3360121 |doi=  }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal  | author=Levy D, Larner A, Chaudhuri A, ''et al.'' |title=Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 23 |pages= 8929-33 |year= 1987 |pmid= 3466167 |doi= }}
* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Res. | volume = 16 | issue = 1 | pages = 55–65 | year = 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
*{{cite journal  | author=Hillier LD, Lennon G, Becker M, ''et al.'' |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807-28 |year= 1997 |pmid= 8889549 |doi=  }}
* {{cite journal | vauthors = Terenzi F, Hui DJ, Merrick WC, Sen GC | title = Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56 | journal = J. Biol. Chem. | volume = 281 | issue = 45 | pages = 34064–71 | year = 2006 | pmid = 16973618 | doi = 10.1074/jbc.M605771200 }}
*{{cite journal | author=Zhu H, Cong JP, Shenk T |title=Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 25 |pages= 13985-90 |year= 1998 |pmid= 9391139 |doi=  }}
* {{cite journal | vauthors = Saha S, Sugumar P, Bhandari P, Rangarajan PN | title = Identification of Japanese encephalitis virus-inducible genes in mouse brain and characterization of GARG39/IFIT2 as a microtubule-associated protein | journal = J. Gen. Virol. | volume = 87 | issue = Pt 11 | pages = 3285–9 | year = 2006 | pmid = 17030862 | doi = 10.1099/vir.0.82107-0 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Gavrilov BG, Monastyrskaia GS, Velikodvorskaia TV, ''et al.'' |title=[Late activation of interferon-induced genes IFI-54k and IFI-56k in human RH cells infected with tick-borne encephalitis virus] |journal=Bioorg. Khim. |volume=29 |issue= 2 |pages= 175-80 |year= 2003 |pmid= 12708317 |doi=  }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal | author=Terenzi F, Hui DJ, Merrick WC, Sen GC |title=Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56. |journal=J. Biol. Chem. |volume=281 |issue= 45 |pages= 34064-71 |year= 2006 |pmid= 16973618 |doi= 10.1074/jbc.M605771200 }}
*{{cite journal | author=Saha S, Sugumar P, Bhandari P, Rangarajan PN |title=Identification of Japanese encephalitis virus-inducible genes in mouse brain and characterization of GARG39/IFIT2 as a microtubule-associated protein. |journal=J. Gen. Virol. |volume=87 |issue= Pt 11 |pages= 3285-9 |year= 2006 |pmid= 17030862 |doi= 10.1099/vir.0.82107-0 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 23:38, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Interferon-induced protein with tetratricopeptide repeats 2 or IFIT2 is a protein found in humans which is encoded by the IFIT2 gene.[1][2][3]

Clinical significance

IFIT2 may play a role in prevention of tumor progression.[4]

References

  1. ↑ Wathelet MG, Szpirer J, Nols CB, Clauss IM, De Wit L, Islam MQ, Levan G, Horisberger MA, Content J, Szpirer C (Nov 1988). "Cloning and chromosomal location of human genes inducible by type I interferon". Somat Cell Mol Genet. 14 (5): 415–26. doi:10.1007/BF01534709. PMID 3175763.
  2. ↑ Wathelet MG, Clauss IM, Content J, Huez GA (Jun 1988). "The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family". FEBS Lett. 231 (1): 164–71. doi:10.1016/0014-5793(88)80724-5. PMID 3360121.
  3. ↑ "Entrez Gene: IFIT2 interferon-induced protein with tetratricopeptide repeats 2".
  4. ↑ Lai KC, Chang KW, Liu CJ, Kao SY, Lee TC (2008). "IFN-induced protein with tetratricopeptide repeats 2 inhibits migration activity and increases survival of oral squamous cell carcinoma". Mol. Cancer Res. 6 (9): 1431–9. doi:10.1158/1541-7786.MCR-08-0141. PMID 18819931.

Further reading


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