Hypermineralocorticoid

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Hypermineralocorticoid

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Hypermineralocorticoid is a hereditary disease characterized by childhood onset hypertension, hypokalemic alkalosis, and low renin and aldosterone secretion. It results from a defect in the activity of the 11-beta-hydroxysteroid dehydrogenase type 2 enzyme which results in inadequate conversion of cortisol to cortisone. The build up of unprocessed cortisol to levels that stimulate mineralocorticoid receptors creates the appearance of having excessive mineralocorticoids.


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