Hyperlipidemia NCEP recommendations for drug therapy of high-risk hyperlipidemia in children and adolescents

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

Children and adolescents with high-risk hyperlipidemia require lipid-lowering drug therapy, particularly those with familial hypercholesterolemia, despite compliance with lifestyle recommendations .

Original Recommendations of the National Cholesterol Education Program (NCEP) Expert Panel for Drug Therapy of High-Risk Hyperlipidemia in Children and Adolescents (DONOT EDIT)

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Consider drug therapy in children >10 years of age (usually wait until menarche for females) and after a 6- to 12-month trial of fat- and cholesterol-restricted dietary management. Consider drug therapy if LDL level remains >4.90 mmol/L (190 mg/dL)' or LDL remains >4.10 mmol/L (160 mg/dL) and there is a positive family history of premature cardiovascular disease >2 other risk factors are present in the child or adolescent after vigorous attempts to control these risk factors. Referral to specialized lipid center may be deemed appropriate. Treatment goal Minimal, LDL <3.35 mmol/L (130 mg/dL) Ideal, LDL <2.85 mmol/L (110 mg/dL

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