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DiseasesDB 29853
eMedicine neuro/578 

Hyperhomocysteinemia is a medical condition characterized by an abnormally large level of homocysteine in the blood.

As a consequence of the biochemical reactions in which homocysteine is involved, deficiencies of the vitamins folic acid, pyridoxine (B6), or B12 can lead to high homocysteine levels.[1] Supplementation with pyridoxine, folic acid, B12 or trimethylglycine (betaine) reduces the concentration of homocysteine in the bloodstream.[2]

Normal fasting homocysteine plasma levels are between 5,0 and 15,9 mmol/l.

See also


  1. Miller JW, Nadeau MR, Smith D, Selhub J (1994). "Vitamin B-6 deficiency vs folate deficiency: comparison of responses to methionine loading in rats". American Journal of Clinical Nutrition. 59: 1033–1039. PMID 8172087.
  2. van Guldener C, Stehouwer CD (2001). "Homocysteine-lowering treatment: an overview". Expert Opinion on Pharmacotherapy. 2 (9): 1449–1460. PMID 11585023.