Homatropine

Homatropine

Clinical data
ATC code	A02BX03 (WHO) S01FA05 (WHO)
Identifiers
IUPAC name (8,8-dimethyl-8-azoniabicyclo[3.2.1]oct-3-yl) 2-hydroxy-2-phenyl-acetate bromide
CAS Number	80-49-9
PubChem CID	6646
DrugBank	APRD01017
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C17H24BrNO3
Molar mass	370.28 g/mol

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Overview

Homatropine (Equipin®, Isopto Homatropine®) is an anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It is used in eye drops as a cycloplegic, to temporarily paralyze accommodation, and as a mydriatic, to dilate the pupil.

Homatropine is less potent than atropine and has a shorter duration of action. It is available as the hydrobromide or methylbromidesalt.

Drugs like hydrocodone are mixed with small amounts of an anticholinergic such as homatropine methylbromide to discourage abuse.

Homatropine is also given as an atropine substitute given to reverse the muscarinic and CNS effects associated with indirect cholinomimetic(anti-AChase) administation.

Side effects

• Blurred vision
• Sensitivity to light

Contraindications

• Untreated glaucoma
• Myasthenia gravis
• Severe heart failure
• Thyrotoxicosis