Hodgkin's lymphoma epidemiology and demographics: Difference between revisions

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__NOTOC__
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{{Hodgkin's lymphoma}}
{{Hodgkin's lymphoma}}
{{CMG}}; {{AE}} {{Rim}}
{{CMG}}; {{AE}} {{Rim}}, {{AS}}


==Overview==
==Overview==
Unlike some [[non-Hodgkin lymphoma|other lymphomas]], whose [[incidence (epidemiology)|incidence]] increases with age, Hodgkin's lymphoma has a bimodal incidence curve; that is, it occurs most frequently in two separate age groups, the first being young adulthood (age 15&ndash;35) and the second being in those over 55 years old although these peaks may vary slightly with nationality.<ref> {{cite book | last=Mauch | first=Peter | coauthors=James Armitage, Volker Diehl, Richard Hoppe, Laurence Weiss | title=Hodgkin's Disease | publisher=[[Lippincott Williams & Wilkins]] | date=1999 | pages=62-64 | isbn=0-7817-1502-4}} </ref> In 2011, the age-adjusted incidence of Hodgkin's lymphoma was 2.71 per 100,000 persons in the United States.<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref> The incidence of Hodgkin's lymphoma is higher among patients with HIV/AIDS; however, in contrast to many other lymphomas associated with HIV infection, Hodgkin's lymphoma occurs most commonly in patients with higher CD4 T cell counts.<ref>{{cite journal |author=Biggar RJ, Jaffe ES, Goedert JJ, Chaturvedi A, Pfeiffer R, Engels EA |title=Hodgkin lymphoma and immunodeficiency in persons with HIV/AIDS |journal=Blood |volume=108 |issue=12 |pages=3786-91 |year=2006 |pmid=16917006 |doi=10.1182/blood-2006-05-024109}}</ref>
Hodgkin's lymphoma has a bimodal age distribution that differs geographically and ethnically in industrialized countries; the early peak occurs in the middle-to-late 20s and the second peak after age 50 years. In developing countries, the early peak occurs before adolescence.<ref name=NCI>{{cite web | title = National Caner Institute Childhood Hodgkin Lymphoma Treatment| url =http://www.cancer.gov/types/lymphoma/hp/child-hodgkin-treatment-pdq#cit/section_1.3}}</ref> In 2015, the incidence of Hodgkins lymphoma was estimated to be 3 cases per 100,000 individuals in the United States.<ref name=NCI>{{cite web | title = National Caner Institute Adult Hodgkin Lymphoma Treatment| url =http://www.cancer.gov/types/lymphoma/hp/adult-hodgkin-treatment-pdq}}</ref> The incidence of Hodgkin's lymphoma is higher among patients with [[HIV]]/[[AIDS]]; however, in contrast to many other lymphomas associated with [[HIV infection]], Hodgkin's lymphoma occurs most commonly in patients who do not have severe immunosupression.<ref>{{cite journal |author=Biggar RJ, Jaffe ES, Goedert JJ, Chaturvedi A, Pfeiffer R, Engels EA |title=Hodgkin lymphoma and immunodeficiency in persons with HIV/AIDS |journal=Blood |volume=108 |issue=12 |pages=3786-91 |year=2006 |pmid=16917006 |doi=10.1182/blood-2006-05-024109}}</ref>  
 
==Epidemiology and Demographics==
==Epidemiology and Demographics==
===Prevalence===
===Prevalence===
 
* In the United States, the age-adjusted prevalence of Hodgkin's lymphoma is 35 per 100,000 in 2011.<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref>
* In the United States, the age adjusted prevalence of Hodgkin's lymphoma is 0.035% in 2011.<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref>


===Incidence===
===Incidence===
 
* In 2015, the incidence of Hodgkins lymphoma was estimated to be 3 cases per 100,000 individuals in the United States.<ref name=NCI>{{cite web | title = National Caner Institute Adult Hodgkin Lymphoma Treatment| url =http://www.cancer.gov/types/lymphoma/hp/adult-hodgkin-treatment-pdq}}</ref>
* The delay-adjusted incidence of Hodgkin's lymphoma in 2011 was estimated to be 2.8 per 100,000 persons in the United States.<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref>
 
* In 2011, the age-adjusted incidence of Hodgkin's lymphoma was 2.71 per 100,000 persons in the United States.<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref>


===Age===
===Age===
 
* Hodgkin's lymphoma has a bimodal age distribution that differs geographically and ethnically in industrialized countries; the early peak occurs in the middle-to-late 20s and the second peak after age 50 years. In developing countries, the early peak occurs before adolescence.<ref name=NCI>{{cite web | title = National Caner Institute Childhood Hodgkin Lymphoma Treatment| url =http://www.cancer.gov/types/lymphoma/hp/child-hodgkin-treatment-pdq#cit/section_1.3}}</ref>
* While the overall age adjusted incidence of Hodgkin's lymphoma in the United States between 2007 and 2011 is 2.7 per 100,000, the age-adjusted incidence of Hodgkin's lymphoma by age category is:<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref>
* The incidence of Hodgkin's lymphoma is estimated to be 2.9 cases per 100,000 adolescents among ages 15 to 19 years in the United States.
* The incidence of Hodgkin's lymphoma is estimated to be 0.9 cases per 100,000 children among ages 10 to 14 years in the United States.
* The incidence of Hodgkin's lymphoma is estimated to be 0.3 cases per 100,000 children among ages 5 to 9 years in the United States.
* The incidence of Hodgkin's lymphoma is estimated to be 0.09 cases per 100,000 children among 4 years of age in the United States.
* While the overall age-adjusted incidence of Hodgkin's lymphoma in the United States between 2007 and 2011 is 2.7 per 100,000, the age-adjusted incidence of Hodgkin's lymphoma by age category is:<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref>
** Between 20 and 29 years: 4.1-4,5 per 100,000
** Between 20 and 29 years: 4.1-4,5 per 100,000
** Under 65 years: 2.5 per 100,000
** Under 65 years: 2.5 per 100,000
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===Gender===
===Gender===
 
* In children <5 year, males are more commonly affected with Hodgkin's lymphoma than females. The male to female ratio is approximately 5.3.<ref name=NCI>{{cite web | title = National Caner Institute Childhood Hodgkin Lymphoma Treatment| url =http://www.cancer.gov/types/lymphoma/hp/child-hodgkin-treatment-pdq#cit/section_1.3}}</ref>
* In the United States, the age adjusted prevalence of Hodgkin's lymphoma by gender in 2011 is:<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref>
* In children aged 15 to 19 year, females are more commonly affected with Hodgkin's lymphoma than males. The male to female ratio is approximately 0.8.
** In males: 0.0372%
* In the United States, the age-adjusted prevalence of Hodgkin's lymphoma by gender in 2011 is:<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref>
** In females: 0.0331%
** In males: 37.2 per 100,000
 
** In females: 33.1 per 100,000
* In the United States, the age-adjusted incidence of Hodgkin's lymphoma by gender on 2011 is:<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref>
** In males: 3.11 per 100,000 persons
** In females: 2.34 per 100,000 persons
* In the United States, the delay-adjusted incidence of Hodgkin's lymphoma by gender in 2011 is:<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref>
* In the United States, the delay-adjusted incidence of Hodgkin's lymphoma by gender in 2011 is:<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref>
** In males: 3.22 per 100,000 persons
** In males: 3.22 per 100,000 persons
** In females: 2.42 per 100,000 persons
** In females: 2.42 per 100,000 persons
* In the United States, the age-adjusted incidence of Hodgkin's lymphoma by gender on 2011 is:<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref>
** In males: 3.11 per 100,000 persons
** In females: 2.34 per 100,000 persons
Shown below is an image depicting the delay-adjusted incidence and observed incidence of Hodgkin's lymphoma by gender and race in the United States between 1975 and 2011.  These graphs are adapted from [[SEER]]: The Surveillance, Epidemiology, and End Results Program of the National Cancer Institute.<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref>
Shown below is an image depicting the delay-adjusted incidence and observed incidence of Hodgkin's lymphoma by gender and race in the United States between 1975 and 2011.  These graphs are adapted from [[SEER]]: The Surveillance, Epidemiology, and End Results Program of the National Cancer Institute.<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref>


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===Race===
===Race===
 
* Shown below is a table depicting the age-adjusted prevalence of Hodgkin's lymphoma by race in 2011 in the United States.<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref>
* Shown below is a table depicting the age adjusted prevalence of Hodgkin's lymphoma by race in 2011 in the United States.<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref>


{| style="cellpadding=0; cellspacing= 0; width: 600px;"
{| style="cellpadding=0; cellspacing= 0; width: 600px;"
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|style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center | || style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center |'''All Races''' ||style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center |'''White''' || style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center |'''Black''' || style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center |'''Asian/Pacific Islander'''  || style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center |'''Hispanic'''  
|style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center | || style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center |'''All Races''' ||style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center |'''White''' || style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center |'''Black''' || style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center |'''Asian/Pacific Islander'''  || style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center |'''Hispanic'''  
|-
|-
| style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center |'''Age-adjusted prevalence'''|| style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |0.035% ||style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |0.04% ||style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |0.0321%||style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |0.0126% ||style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |0.0236%
| style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center |'''Age-adjusted prevalence'''|| style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |35 per 100,000 ||style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |40 per 100,000 ||style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |32.1 per 100,000||style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |12.6 per 100,000 ||style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |23.6 per 100,000
|}
|}


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==References==
==References==
{{reflist|2}}
{{reflist|2}}
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Latest revision as of 22:13, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rim Halaby, M.D. [2], Sowminya Arikapudi, M.B,B.S. [3]

Overview

Hodgkin's lymphoma has a bimodal age distribution that differs geographically and ethnically in industrialized countries; the early peak occurs in the middle-to-late 20s and the second peak after age 50 years. In developing countries, the early peak occurs before adolescence.[1] In 2015, the incidence of Hodgkins lymphoma was estimated to be 3 cases per 100,000 individuals in the United States.[1] The incidence of Hodgkin's lymphoma is higher among patients with HIV/AIDS; however, in contrast to many other lymphomas associated with HIV infection, Hodgkin's lymphoma occurs most commonly in patients who do not have severe immunosupression.[2]

Epidemiology and Demographics

Prevalence

  • In the United States, the age-adjusted prevalence of Hodgkin's lymphoma is 35 per 100,000 in 2011.[3]

Incidence

  • In 2015, the incidence of Hodgkins lymphoma was estimated to be 3 cases per 100,000 individuals in the United States.[1]

Age

  • Hodgkin's lymphoma has a bimodal age distribution that differs geographically and ethnically in industrialized countries; the early peak occurs in the middle-to-late 20s and the second peak after age 50 years. In developing countries, the early peak occurs before adolescence.[1]
  • The incidence of Hodgkin's lymphoma is estimated to be 2.9 cases per 100,000 adolescents among ages 15 to 19 years in the United States.
  • The incidence of Hodgkin's lymphoma is estimated to be 0.9 cases per 100,000 children among ages 10 to 14 years in the United States.
  • The incidence of Hodgkin's lymphoma is estimated to be 0.3 cases per 100,000 children among ages 5 to 9 years in the United States.
  • The incidence of Hodgkin's lymphoma is estimated to be 0.09 cases per 100,000 children among 4 years of age in the United States.
  • While the overall age-adjusted incidence of Hodgkin's lymphoma in the United States between 2007 and 2011 is 2.7 per 100,000, the age-adjusted incidence of Hodgkin's lymphoma by age category is:[3]
    • Between 20 and 29 years: 4.1-4,5 per 100,000
    • Under 65 years: 2.5 per 100,000
    • 65 and over: 4.2 per 100,000

Gender

  • In children <5 year, males are more commonly affected with Hodgkin's lymphoma than females. The male to female ratio is approximately 5.3.[1]
  • In children aged 15 to 19 year, females are more commonly affected with Hodgkin's lymphoma than males. The male to female ratio is approximately 0.8.
  • In the United States, the age-adjusted prevalence of Hodgkin's lymphoma by gender in 2011 is:[3]
    • In males: 37.2 per 100,000
    • In females: 33.1 per 100,000
  • In the United States, the age-adjusted incidence of Hodgkin's lymphoma by gender on 2011 is:[3]
    • In males: 3.11 per 100,000 persons
    • In females: 2.34 per 100,000 persons
  • In the United States, the delay-adjusted incidence of Hodgkin's lymphoma by gender in 2011 is:[3]
    • In males: 3.22 per 100,000 persons
    • In females: 2.42 per 100,000 persons

Shown below is an image depicting the delay-adjusted incidence and observed incidence of Hodgkin's lymphoma by gender and race in the United States between 1975 and 2011. These graphs are adapted from SEER: The Surveillance, Epidemiology, and End Results Program of the National Cancer Institute.[3]

The delay-adjusted incidence and observed incidence of Hodgkin's lymphoma by gender and race in the United States

Race

  • Shown below is a table depicting the age-adjusted prevalence of Hodgkin's lymphoma by race in 2011 in the United States.[3]
All Races White Black Asian/Pacific Islander Hispanic
Age-adjusted prevalence 35 per 100,000 40 per 100,000 32.1 per 100,000 12.6 per 100,000 23.6 per 100,000

Shown below is an image depicting the incidence of Hodgkin's lymphoma by race in the United States between 1975 and 2011.[3]

The incidence of Hodgkin's lymphoma by race in the United States between 1975 and 2011

API: Asian/Pacific Islander; AI/AN: American Indian/ Alaska Native

References

  1. 1.0 1.1 1.2 1.3 1.4 "National Caner Institute Childhood Hodgkin Lymphoma Treatment".
  2. Biggar RJ, Jaffe ES, Goedert JJ, Chaturvedi A, Pfeiffer R, Engels EA (2006). "Hodgkin lymphoma and immunodeficiency in persons with HIV/AIDS". Blood. 108 (12): 3786–91. doi:10.1182/blood-2006-05-024109. PMID 16917006.
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.


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