Hippocalcin-like protein 1: Difference between revisions

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{{Underlinked|date=December 2012}}
{{Infobox_gene}}
{{Infobox_gene}}
'''Hippocalcin-like protein 1''' is a [[protein]] that in humans is encoded by the ''HPCAL1'' [[gene]].<ref name="pmid8038222">{{cite journal |vauthors=Kobayashi M, Takamatsu K, Fujishiro M, Saitoh S, Noguchi T | title = Molecular cloning of a novel calcium-binding protein structurally related to hippocalcin from human brain and chromosomal mapping of its gene | journal = Biochim Biophys Acta | volume = 1222 | issue = 3 | pages = 515–8 |date=Aug 1994 | pmid = 8038222 | pmc =  | doi =10.1016/0167-4889(94)90062-0  }}</ref><ref name="pmid14739275">{{cite journal |vauthors=Oikawa K, Kimura S, Aoki N, Atsuta Y, Takiyama Y, Nagato T, Yanai M, Kobayashi H, Sato K, Sasajima T, Tateno M | title = Neuronal calcium sensor protein visinin-like protein-3 interacts with microsomal cytochrome b5 in a Ca2+-dependent manner | journal = J Biol Chem | volume = 279 | issue = 15 | pages = 15142–52 |date=Apr 2004 | pmid = 14739275 | pmc =  | doi = 10.1074/jbc.M312766200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HPCAL1 hippocalcin-like 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3241| accessdate = }}</ref>
'''Hippocalcin-like protein 1''' is a [[protein]] that in [[human]]s is encoded by the ''HPCAL1'' [[gene]].<ref name="pmid8038222">{{cite journal |vauthors=Kobayashi M, Takamatsu K, Fujishiro M, Saitoh S, Noguchi T | title = Molecular cloning of a novel calcium-binding protein structurally related to hippocalcin from human brain and chromosomal mapping of its gene | journal = Biochim Biophys Acta | volume = 1222 | issue = 3 | pages = 515–8 |date=Aug 1994 | pmid = 8038222 | pmc =  | doi =10.1016/0167-4889(94)90062-0  }}</ref><ref name="pmid14739275">{{cite journal |vauthors=Oikawa K, Kimura S, Aoki N, Atsuta Y, Takiyama Y, Nagato T, Yanai M, Kobayashi H, Sato K, Sasajima T, Tateno M | title = Neuronal calcium sensor protein visinin-like protein-3 interacts with microsomal cytochrome b5 in a Ca2+-dependent manner | journal = J Biol Chem | volume = 279 | issue = 15 | pages = 15142–52 |date=Apr 2004 | pmid = 14739275 | pmc =  | doi = 10.1074/jbc.M312766200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HPCAL1 hippocalcin-like 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3241| accessdate = }}</ref>


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| section_title =  
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| summary_text = The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain.<ref name="pmid17311005">{{cite journal | author = Burgoyne RD| title = Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling| journal = Nat. Rev. Neurosci. | volume = 8 | issue = 3 |pages = 182–193 | year = 2007 | pmid = 17311005 | pmc = 1887812 | doi = 10.1038/nrn2093 }}</ref> It is highly similar to human hippocalcin protein and nearly identical to the rat and mouse hippocalcin like-1 proteins. It may be involved in the calcium-dependent regulation of rhodopsin phosphorylation and may be of relevance for neuronal signalling in the central nervous system. There are two alternatively spliced transcript variants of this gene, with multiple polyadenylation sites.<ref name="entrez" />
| summary_text = The protein [[Genetic code|encoded]] by this [[gene]] is a member of the [[neuron]]-specific [[Calcium-binding protein|calcium-binding proteins]] family found in the [[retina]] and [[brain]].<ref name="pmid17311005">{{cite journal | author = Burgoyne RD| title = Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling| journal = Nat. Rev. Neurosci. | volume = 8 | issue = 3 |pages = 182–193 | year = 2007 | pmid = 17311005 | pmc = 1887812 | doi = 10.1038/nrn2093 }}</ref> It is highly similar to human [[hippocalcin]] protein, and nearly identical to rat and mouse hippocalcin like-1 proteins. It may be involved in the [[calcium]]-dependent regulation of [[rhodopsin]] [[phosphorylation]], and may be of relevance to neuronal signaling in the [[central nervous system]]. There are two alternatively spliced [[Transcription (biology)|transcript]] variants of this gene, with multiple [[polyadenylation]] sites.<ref name="entrez" />
}}
}}


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*{{cite journal  | author=Bernstein HG |title=Regional and cellular distribution of neural visinin-like protein immunoreactivities (VILIP-1 and VILIP-3) in human brain |journal=J. Neurocytol. |volume=28 |issue= 8 |pages= 655–62 |year= 2000 |pmid= 10851344 |doi=10.1023/A:1007056731551  |name-list-format=vanc| author2=Baumann B  | author3=Danos P  | display-authors=3  | last4=Diekmann  | first4=Silvia  | last5=Bogerts  | first5=Bernhard  | last6=Gundelfinger  | first6=Eckart D.  | last7=Braunewell  | first7=Karl-Heinz  }}
*{{cite journal  | author=Bernstein HG |title=Regional and cellular distribution of neural visinin-like protein immunoreactivities (VILIP-1 and VILIP-3) in human brain |journal=J. Neurocytol. |volume=28 |issue= 8 |pages= 655–62 |year= 2000 |pmid= 10851344 |doi=10.1023/A:1007056731551  |name-list-format=vanc| author2=Baumann B  | author3=Danos P  | display-authors=3  | last4=Diekmann  | first4=Silvia  | last5=Bogerts  | first5=Bernhard  | last6=Gundelfinger  | first6=Eckart D.  | last7=Braunewell  | first7=Karl-Heinz  }}
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948  }}
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948  }}
*{{cite journal  | author=Braunewell K |title=Abnormal localization of two neuronal calcium sensor proteins, visinin-like proteins (vilips)-1 and -3, in neocortical brain areas of Alzheimer disease patients |journal=Dementia and geriatric cognitive disorders |volume=12 |issue= 2 |pages= 110–6 |year= 2001 |pmid= 11173883 |doi=10.1159/000051244  |name-list-format=vanc| author2=Riederer P  | author3=Spilker C  | display-authors=3  | last4=Gundelfinger  | first4=E.D.  | last5=Bogerts  | first5=B.  | last6=Bernstein  | first6=H.-G.  }}
*{{cite journal  | author=Braunewell K |title=Abnormal localization of two neuronal calcium sensor proteins, visinin-like proteins (vilips)-1 and -3, in neocortical brain areas of Alzheimer disease patients |journal=Dementia and Geriatric Cognitive Disorders |volume=12 |issue= 2 |pages= 110–6 |year= 2001 |pmid= 11173883 |doi=10.1159/000051244  |name-list-format=vanc| author2=Riederer P  | author3=Spilker C  | display-authors=3  | last4=Gundelfinger  | first4=E.D.  | last5=Bogerts  | first5=B.  | last6=Bernstein  | first6=H.-G.  }}
*{{cite journal  | author=Ivings L |title=Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin |journal=Biochem. J. |volume=363 |issue= Pt 3 |pages= 599–608 |year= 2002 |pmid= 11964161 |doi=10.1042/0264-6021:3630599  | pmc=1222513  |name-list-format=vanc| author2=Pennington SR  | author3=Jenkins R  | display-authors=3  | last4=Weiss  | first4=Jamie L.  | last5=Burgoyne  | first5=Robert D.  }}
*{{cite journal  | author=Ivings L |title=Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin |journal=Biochem. J. |volume=363 |issue= Pt 3 |pages= 599–608 |year= 2002 |pmid= 11964161 |doi=10.1042/0264-6021:3630599  | pmc=1222513  |name-list-format=vanc| author2=Pennington SR  | author3=Jenkins R  | display-authors=3  | last4=Weiss  | first4=Jamie L.  | last5=Burgoyne  | first5=Robert D.  }}
*{{cite journal  |vauthors=Spilker C, Gundelfinger ED, Braunewell KH |title=Evidence for different functional properties of the neuronal calcium sensor proteins VILIP-1 and VILIP-3: from subcellular localization to cellular function |journal=Biochim. Biophys. Acta |volume=1600 |issue= 1–2 |pages= 118–27 |year= 2002 |pmid= 12445467 |doi=  10.1016/s1570-9639(02)00452-1}}
*{{cite journal  |vauthors=Spilker C, Gundelfinger ED, Braunewell KH |title=Evidence for different functional properties of the neuronal calcium sensor proteins VILIP-1 and VILIP-3: from subcellular localization to cellular function |journal=Biochim. Biophys. Acta |volume=1600 |issue= 1–2 |pages= 118–27 |year= 2002 |pmid= 12445467 |doi=  10.1016/s1570-9639(02)00452-1}}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Pribanic S |title=Expression of visinin-like protein-3 in mouse kidney |journal=Nephron. Physiology |volume=95 |issue= 4 |pages=76–82 |year= 2004 |pmid= 14694264 |doi= 10.1159/000074844  |name-list-format=vanc| author2=Loffing J  | author3=Madjdpour C  | display-authors=3  | last4=Bacic  | first4=Desa  | last5=Gisler  | first5=Serge  | last6=Braunewell  | first6=Karl-Heinz  | last7=Biber  | first7=J&Uuml;rg  | last8=Murer  | first8=Heini }}
*{{cite journal  | author=Pribanic S |title=Expression of visinin-like protein-3 in mouse kidney |journal=Nephron Physiology |volume=95 |issue= 4 |pages=76–82 |year= 2004 |pmid= 14694264 |doi= 10.1159/000074844  |name-list-format=vanc| author2=Loffing J  | author3=Madjdpour C  | display-authors=3  | last4=Bacic  | first4=Desa  | last5=Gisler  | first5=Serge  | last6=Braunewell  | first6=Karl-Heinz  | last7=Biber  | first7=J&Uuml;rg  | last8=Murer  | first8=Heini }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Wiemann S |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704  | pmc=528930  |name-list-format=vanc| author2=Arlt D  | author3=Huber W  | display-authors=3  | last4=Wellenreuther  | first4=R  | last5=Schleeger  | first5=S  | last6=Mehrle  | first6=A  | last7=Bechtel  | first7=S  | last8=Sauermann  | first8=M  | last9=Korf  | first9=U }}
*{{cite journal  | author=Wiemann S |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704  | pmc=528930  |name-list-format=vanc| author2=Arlt D  | author3=Huber W  | display-authors=3  | last4=Wellenreuther  | first4=R  | last5=Schleeger  | first5=S  | last6=Mehrle  | first6=A  | last7=Bechtel  | first7=S  | last8=Sauermann  | first8=M  | last9=Korf  | first9=U }}
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[[Category:EF-hand-containing proteins]]


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{{gene-2-stub}}
[[Category:EF-hand-containing proteins]]

Latest revision as of 03:20, 25 July 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Hippocalcin-like protein 1 is a protein that in humans is encoded by the HPCAL1 gene.[1][2][3]

The protein encoded by this gene is a member of the neuron-specific calcium-binding proteins family found in the retina and brain.[4] It is highly similar to human hippocalcin protein, and nearly identical to rat and mouse hippocalcin like-1 proteins. It may be involved in the calcium-dependent regulation of rhodopsin phosphorylation, and may be of relevance to neuronal signaling in the central nervous system. There are two alternatively spliced transcript variants of this gene, with multiple polyadenylation sites.[3]

References

  1. ↑ Kobayashi M, Takamatsu K, Fujishiro M, Saitoh S, Noguchi T (Aug 1994). "Molecular cloning of a novel calcium-binding protein structurally related to hippocalcin from human brain and chromosomal mapping of its gene". Biochim Biophys Acta. 1222 (3): 515–8. doi:10.1016/0167-4889(94)90062-0. PMID 8038222.
  2. ↑ Oikawa K, Kimura S, Aoki N, Atsuta Y, Takiyama Y, Nagato T, Yanai M, Kobayashi H, Sato K, Sasajima T, Tateno M (Apr 2004). "Neuronal calcium sensor protein visinin-like protein-3 interacts with microsomal cytochrome b5 in a Ca2+-dependent manner". J Biol Chem. 279 (15): 15142–52. doi:10.1074/jbc.M312766200. PMID 14739275.
  3. ↑ 3.0 3.1 "Entrez Gene: HPCAL1 hippocalcin-like 1".
  4. ↑ Burgoyne RD (2007). "Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.

Further reading

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