Hereditary pancreatitis: Difference between revisions
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'''For patient information click [[{{PAGENAME}} (patient information)|here]]''' | '''For patient information click [[{{PAGENAME}} (patient information)|here]]''' | ||
'''For full discussion on Pancreatitis click [[Pancreatitis|here]].''' | '''For full discussion on Pancreatitis click [[Pancreatitis|here]].''' | ||
{{CMG}} | {{CMG}} | ||
==Overview== | ==Overview== | ||
'''Hereditary Pancreatitis''' is a genetic disease affecting enzyme production in the pancreas. | '''Hereditary Pancreatitis''' is a genetic disease affecting enzyme production in the pancreas. | ||
==Pathophysiology== | ==Pathophysiology== | ||
In the pancreas, a genetic mutation causes the enzyme [[trypsinogen]] to be made in a way which renders it resistant to inactivation through [[autolysis]]. Normally this autolysis mechanism prevents trypsinogen from being activated within the pancreas. However, when the abnormal trypsinogen is activated, it causes a chain reaction where all the trypsinogen in the pancreas is activated, effectively digesting the pancreas from the inside. | In the pancreas, a genetic mutation causes the enzyme [[trypsinogen]] to be made in a way which renders it resistant to inactivation through [[autolysis]]. Normally this autolysis mechanism prevents trypsinogen from being activated within the pancreas. However, when the abnormal trypsinogen is activated, it causes a chain reaction where all the trypsinogen in the pancreas is activated, effectively digesting the pancreas from the inside. | ||
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===Prevalence=== | ===Prevalence=== | ||
Most estimates place the number of individuals with hereditary pancreatitis in the United States at 1000. | Most estimates place the number of individuals with hereditary pancreatitis in the United States at 1000. | ||
==Diagnosis== | |||
==Symptoms== | ===History and Symptoms=== | ||
Symptoms are generally the same as [[acute pancreatitis]], including | Symptoms are generally the same as [[acute pancreatitis]], including | ||
* Severe [[abdominal pain]] | * Severe [[abdominal pain]] | ||
* [[Vomiting]] | * [[Vomiting]] | ||
* [[Diarrhea]] | * [[Diarrhea]] | ||
==Treatment== | |||
== | ===Medical Therapy=== | ||
There is no treatment for the disease, although complications such as malnutrition can be treated with supplimentary pancreatic enzymes. | There is no treatment for the disease, although complications such as malnutrition can be treated with supplimentary pancreatic enzymes. | ||
==References== | ==References== | ||
{{ | {{reflist|2}} | ||
{{Gastroenterology}} | {{Gastroenterology}} | ||
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[[Category:Gastroenterology]] | [[Category:Gastroenterology]] | ||
[[Category:Genetic disorders]] | [[Category:Genetic disorders]] | ||
[[Category:Disease]] | |||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
'''Bold text''' | '''Bold text''' | ||
Revision as of 04:38, 20 February 2013
For patient information click here
For full discussion on Pancreatitis click here. Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Hereditary Pancreatitis is a genetic disease affecting enzyme production in the pancreas.
Pathophysiology
In the pancreas, a genetic mutation causes the enzyme trypsinogen to be made in a way which renders it resistant to inactivation through autolysis. Normally this autolysis mechanism prevents trypsinogen from being activated within the pancreas. However, when the abnormal trypsinogen is activated, it causes a chain reaction where all the trypsinogen in the pancreas is activated, effectively digesting the pancreas from the inside.
Epidemiology and Demographics
Prevalence
Most estimates place the number of individuals with hereditary pancreatitis in the United States at 1000.
Diagnosis
History and Symptoms
Symptoms are generally the same as acute pancreatitis, including
- Severe abdominal pain
- Vomiting
- Diarrhea
Treatment
Medical Therapy
There is no treatment for the disease, although complications such as malnutrition can be treated with supplimentary pancreatic enzymes.
References
Template:WikiDoc Sources
Bold text