Hepatocellular adenoma pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]

Overview

Pathophysiology

On gross pathology, well circumscribed, nonlobulated,[1] smooth and soft, white to yellow to brown lesions, are characteristic findings of a solitary hepatocellular adenoma.

On microscopic histopathological analysis, cords of hepatocytes that have a high glycogen and fat content, lack of normal hepatic parenchymal architecture and an absence of portal tracts and hepatic veins are characteristic findings of hepatocellular adenoma.[2]

References

  1. Grazioli L, Federle MP, Brancatelli G, Ichikawa T, Olivetti L, Blachar A (2001). "Hepatic adenomas: imaging and pathologic findings". Radiographics. 21 (4): 877–92, discussion 892-4. doi:10.1148/radiographics.21.4.g01jl04877. PMID 11452062.
  2. Barthelmes L, Tait IS (2005). "Liver cell adenoma and liver cell adenomatosis". HPB (Oxford). 7 (3): 186–96. doi:10.1080/13651820510028954. PMC 2023950. PMID 18333188.


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