Hepatitis D other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Varun Kumar, M.B.B.S. [2]

Liver Biopsy

• Liver biopsy is not routinely indicated in diagnosis of acute hepatitis D unless the serologic diagnosis of hepatitis is inconclusive. However, liver biopsy is indicated in chronic liver disease to evaluate for cirrhosis or fibrosis.

• Histopathologic findings are similar to that observed in HBV infection. Acidophilic cytoplasm in hepatocytes with lymphocytic infiltrates may be observed.

• Immunohistochemical staining may be positive for HDV antigen with suppression of HBsAg in case of superinfection.