Hepatitis D other diagnostic studies: Difference between revisions

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{{Hepatitis D}}
{{Hepatitis D}}
{{CMG}}; {{AOEIC}} {{VK}}
{{CMG}}; {{AE}} {{VK}}; {{JS}} {{JM}}
 
==Overview==


==Other Diagnostic Studies==
==Other Diagnostic Studies==
===Liver Biopsy:===
===Liver Biopsy:===
Liver transplant is the only remaining treatment option for patients with liver failure, who are not candidates for treatment with interferon-alpha. The outcome of liver tranplant in patients with hepatitis D is good.
Liver transplant is the only remaining treatment option for patients with liver failure, who are not candidates for treatment with interferon-alpha. The outcome of liver tranplant in patients with hepatitis D is good.
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*[[Immunohistochemical staining]] may be positive for HDV antigen with suppression of [[HBsAg]] in case of superinfection.
*[[Immunohistochemical staining]] may be positive for HDV antigen with suppression of [[HBsAg]] in case of superinfection.
===Endoscopy===
*Patients with [[liver cirrhosis]] should be evaluated for the presence of [[esophageal varices]].<ref name="pmid23242761">{{cite journal| author=Heidrich B, Manns MP, Wedemeyer H| title=Treatment options for hepatitis delta virus infection. | journal=Curr Infect Dis Rep | year= 2013 | volume= 15 | issue= 1 | pages= 31-8 | pmid=23242761 | doi=10.1007/s11908-012-0307-z | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23242761  }} </ref>


==References==
==References==

Revision as of 04:19, 8 August 2014

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Varun Kumar, M.B.B.S. [2]; João André Alves Silva, M.D. [3] Jolanta Marszalek, M.D. [4]

Overview

Other Diagnostic Studies

Liver Biopsy:

Liver transplant is the only remaining treatment option for patients with liver failure, who are not candidates for treatment with interferon-alpha. The outcome of liver tranplant in patients with hepatitis D is good.


  • Liver biopsy is not routinely indicated in diagnosis of acute hepatitis D unless the serologic diagnosis of hepatitis is inconclusive. However, liver biopsy is indicated in chronic liver disease to evaluate for cirrhosis or fibrosis.
  • Histopathologic findings are similar to that observed in HBV infection. Acidophilic cytoplasm in hepatocytes with lymphocytic infiltrates may be observed.

Endoscopy

References

  1. Heidrich B, Manns MP, Wedemeyer H (2013). "Treatment options for hepatitis delta virus infection". Curr Infect Dis Rep. 15 (1): 31–8. doi:10.1007/s11908-012-0307-z. PMID 23242761.

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